Imaging assessment of conjunctival goblet cells in dry eye disease.
conjunctival goblet cells
dry eye disease
imaging assessment
Journal
Clinical & experimental ophthalmology
ISSN: 1442-9071
Titre abrégé: Clin Exp Ophthalmol
Pays: Australia
ID NLM: 100896531
Informations de publication
Date de publication:
30 Mar 2024
30 Mar 2024
Historique:
revised:
06
03
2024
received:
27
11
2023
accepted:
13
03
2024
medline:
30
3
2024
pubmed:
30
3
2024
entrez:
30
3
2024
Statut:
aheadofprint
Résumé
Dry eye disease (DED) is a widespread, multifactorial, and chronic disorder of the ocular surface with disruption of tear film homeostasis as its core trait. Conjunctival goblet cells (CGCs) are specialised secretory cells found in the conjunctival epithelium that participate in tear film formation by secreting mucin. Changes in both the structure and function of CGCs are hallmarks of DED, and imaging assessment of CGCs is important for the diagnosis, classification, and severity evaluation of DED. Existing imaging methods include conjunctival biopsy, conjunctival impression cytology and in vivo confocal microscopy, which can be used to assess the morphology, distribution, and density of the CGCs. Recently, moxifloxacin-based fluorescence microscopy has emerged as a novel technique that enables efficient, non-invasive and in vivo imaging of CGCs. This article presents a comprehensive overview of both the structure and function of CGCs and their alterations in the context of DED, as well as current methods of CGCs imaging assessment. Additionally, potential directions for the visual evaluation of CGCs are discussed.
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : National Natural Science Foundation of China
ID : 82230033
Organisme : National Natural Science Foundation of China
ID : 82271133
Organisme : Guangdong Provincial Department of Science and Technology
ID : 2021TQ06Y137
Organisme : Guangdong Provincial Department of Science and Technology
ID : 2021TX06Y127
Organisme : Fundamental Research Funds of the State Key Laboratory of Ophthalmology
Informations de copyright
© 2024 Royal Australian and New Zealand College of Ophthalmologists.
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