Longitudinal Study of Different Progression Patterns in High-Risk Cutaneous Squamous Cell Carcinoma.
ESTUDIO LONGITUDINAL DE LOS DIFERENTES PATRONES DE PROGRESIÓN EN EL CARCINOMA CUTÁNEO DE CÉLULAS ESCAMOSAS DE ALTO RIESGO.
Cutaneous squamous cell carcinoma
Disease progression
Lymphatic metastasis
Neoplastic metastasis
Prognosis
carcinoma cutáneo de células escamosas
metástasis linfática
metástasis neoplásica
progresión de la enfermedad
pronóstico
Journal
Actas dermo-sifiliograficas
ISSN: 1578-2190
Titre abrégé: Actas Dermosifiliogr
Pays: Spain
ID NLM: 0373062
Informations de publication
Date de publication:
28 Mar 2024
28 Mar 2024
Historique:
received:
15
09
2023
accepted:
11
03
2024
medline:
31
3
2024
pubmed:
31
3
2024
entrez:
30
3
2024
Statut:
aheadofprint
Résumé
Cutaneous squamous cell carcinoma (cSCC) is the second leading cause of skin cancer mortality in Europe. Few studies have analyzed the different pathways of this tumor progression in its natural history. The main objective of this study was to analyze the different metastatic and progression pathways and their temporal occurrence in the evolution of cSCC. We conducted a multicenter, retrospective, and observational study of consecutive high-risk sSCCs included in the SQUAMATA project. A total of 222 out of the 1346 patients included relapsed. The most frequent route of progression was the lymphatic one (62.6%). A total of 20.2% of the cases with lymphatic progression developed distant metastases. Only 1 case (3.1%) of distant metastasis followed local recurrence without previous lymphatic metastasis. The median time to disease-related mortality was longer in patients who developed systemic metastases than in those who died of locoregional progression. The mortality of patients with cSCC is mostly due to the regional progression of their lymphatic metastases. The appearance of distant metastases is practically always (96.9%) associated with previous lymphatic metastatic progression. Therefore, in the future, new studies will be needed to assess the regional management of cSCC in both surgical and adjuvant therapies.
Sections du résumé
BACKGROUND AND OBJECTIVE
OBJECTIVE
Cutaneous squamous cell carcinoma (cSCC) is the second leading cause of skin cancer mortality in Europe. Few studies have analyzed the different pathways of this tumor progression in its natural history. The main objective of this study was to analyze the different metastatic and progression pathways and their temporal occurrence in the evolution of cSCC.
MATERIAL AND METHOD
METHODS
We conducted a multicenter, retrospective, and observational study of consecutive high-risk sSCCs included in the SQUAMATA project.
RESULTS
RESULTS
A total of 222 out of the 1346 patients included relapsed. The most frequent route of progression was the lymphatic one (62.6%). A total of 20.2% of the cases with lymphatic progression developed distant metastases. Only 1 case (3.1%) of distant metastasis followed local recurrence without previous lymphatic metastasis. The median time to disease-related mortality was longer in patients who developed systemic metastases than in those who died of locoregional progression.
CONCLUSIONS
CONCLUSIONS
The mortality of patients with cSCC is mostly due to the regional progression of their lymphatic metastases. The appearance of distant metastases is practically always (96.9%) associated with previous lymphatic metastatic progression. Therefore, in the future, new studies will be needed to assess the regional management of cSCC in both surgical and adjuvant therapies.
Identifiants
pubmed: 38554750
pii: S0001-7310(24)00263-1
doi: 10.1016/j.ad.2024.03.018
pii:
doi:
Types de publication
Journal Article
Langues
eng
spa
Sous-ensembles de citation
IM
Informations de copyright
Copyright © 2024 AEDV. Publicado por Elsevier España, S.L.U. All rights reserved.