The EC-COMPASS: Long-term, Multi-Centre Surveillance of Enterobacter cloacae complex - a Clinical Perspective.
Enterobacter cloacae complex
antimicrobial resistance
colonization
healthcare-associated infection
screening
surveillance
Journal
The Journal of hospital infection
ISSN: 1532-2939
Titre abrégé: J Hosp Infect
Pays: England
ID NLM: 8007166
Informations de publication
Date de publication:
28 Mar 2024
28 Mar 2024
Historique:
received:
08
01
2024
revised:
02
03
2024
accepted:
13
03
2024
medline:
31
3
2024
pubmed:
31
3
2024
entrez:
30
3
2024
Statut:
aheadofprint
Résumé
Enterobacter cloacae complex (ECCO) comprises closely related Enterobacteriaceae, causing a variety of infections ranging from mild urinary tract infections to severe bloodstream infections. ECCO has emerged as a significant cause of healthcare-associated infections, particularly in neonatal and adult intensive care. The Enterobacter Cloacae COMplex PASsive Surveillance (EC-COMPASS) aims to provide a detailed multicentre overview of ECCO epidemiology and resistance patterns detected in routine microbiological diagnostics in four German tertiary care hospitals. In a sentinel cluster of four German tertiary care hospitals, all culture-positive ECCO results between January 01, 2020, and December 31, 2022, were analysed based on Hybase® laboratory data. Analysis of 31,193 ECCO datasets from 14,311 patients revealed a higher incidence in male patients (p<0.05), although no significant differences were observed in ECCO infection phenotypes. The most common sources of ECCO were swabs (42.7%), urine (17.5%), respiratory secretions (16.1%), blood cultures (8.9%), and tissue samples (5.6%). The annual bacteraemia rate remained steady at approximately 33 cases per hospital. Invasive ECCO infections were predominantly found in oncology and intensive care units. Incidences of nosocomial outbreaks were infrequent and limited in scope. Notably, resistance to carbapenems was consistently low. EC-COMPASS offers a profound clinical perspective on ECCO infections in German tertiary healthcare settings, highlighting elderly men in oncology and intensive care units as especially vulnerable to ECCO infections. Early detection strategies targeting at-risk patients could improve ECCO infection management.
Sections du résumé
BACKGROUND
BACKGROUND
Enterobacter cloacae complex (ECCO) comprises closely related Enterobacteriaceae, causing a variety of infections ranging from mild urinary tract infections to severe bloodstream infections. ECCO has emerged as a significant cause of healthcare-associated infections, particularly in neonatal and adult intensive care.
AIM
OBJECTIVE
The Enterobacter Cloacae COMplex PASsive Surveillance (EC-COMPASS) aims to provide a detailed multicentre overview of ECCO epidemiology and resistance patterns detected in routine microbiological diagnostics in four German tertiary care hospitals.
METHODS
METHODS
In a sentinel cluster of four German tertiary care hospitals, all culture-positive ECCO results between January 01, 2020, and December 31, 2022, were analysed based on Hybase® laboratory data.
FINDINGS
RESULTS
Analysis of 31,193 ECCO datasets from 14,311 patients revealed a higher incidence in male patients (p<0.05), although no significant differences were observed in ECCO infection phenotypes. The most common sources of ECCO were swabs (42.7%), urine (17.5%), respiratory secretions (16.1%), blood cultures (8.9%), and tissue samples (5.6%). The annual bacteraemia rate remained steady at approximately 33 cases per hospital. Invasive ECCO infections were predominantly found in oncology and intensive care units. Incidences of nosocomial outbreaks were infrequent and limited in scope. Notably, resistance to carbapenems was consistently low.
CONCLUSION
CONCLUSIONS
EC-COMPASS offers a profound clinical perspective on ECCO infections in German tertiary healthcare settings, highlighting elderly men in oncology and intensive care units as especially vulnerable to ECCO infections. Early detection strategies targeting at-risk patients could improve ECCO infection management.
Identifiants
pubmed: 38554809
pii: S0195-6701(24)00104-X
doi: 10.1016/j.jhin.2024.03.010
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Copyright © 2024 The Healthcare Infection Society. Published by Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.