The acute phase reactant orosomucoid-2 directly promotes rheumatoid inflammation.
Journal
Experimental & molecular medicine
ISSN: 2092-6413
Titre abrégé: Exp Mol Med
Pays: United States
ID NLM: 9607880
Informations de publication
Date de publication:
01 Apr 2024
01 Apr 2024
Historique:
received:
27
08
2023
accepted:
20
12
2023
revised:
04
12
2023
medline:
1
4
2024
pubmed:
1
4
2024
entrez:
31
3
2024
Statut:
aheadofprint
Résumé
Acute phase proteins involved in chronic inflammatory diseases have not been systematically analyzed. Here, global proteome profiling of serum and urine revealed that orosomucoid-2 (ORM2), an acute phase reactant, was differentially expressed in rheumatoid arthritis (RA) patients and showed the highest fold change. Therefore, we questioned the extent to which ORM2, which is produced mainly in the liver, actively participates in rheumatoid inflammation. Surprisingly, ORM2 expression was upregulated in the synovial fluids and synovial membranes of RA patients. The major cell types producing ORM2 were synovial macrophages and fibroblast-like synoviocytes (FLSs) from RA patients. Recombinant ORM2 robustly increased IL-6, TNF-α, CXCL8 (IL-8), and CCL2 production by RA macrophages and FLSs via the NF-κB and p38 MAPK pathways. Interestingly, glycophorin C, a membrane protein for determining erythrocyte shape, was the receptor for ORM2. Intra-articular injection of ORM2 increased the severity of arthritis in mice and accelerated the infiltration of macrophages into the affected joints. Moreover, circulating ORM2 levels correlated with RA activity and radiographic progression. In conclusion, the acute phase protein ORM2 can directly increase the production of proinflammatory mediators and promote chronic arthritis in mice, suggesting that ORM2 could be a new therapeutic target for RA.
Identifiants
pubmed: 38556552
doi: 10.1038/s12276-024-01188-0
pii: 10.1038/s12276-024-01188-0
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : National Research Foundation of Korea (NRF)
ID : NRF-2015R1A3A2032927
Organisme : National Research Foundation of Korea (NRF)
ID : NRF-2021R1I1A2059487
Organisme : National Research Foundation of Korea (NRF)
ID : NRF-2019R1A2C2010897
Organisme : Ministry of Health and Welfare (Ministry of Health, Welfare and Family Affairs)
ID : 21A0503L1
Informations de copyright
© 2024. The Author(s).
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