Molecular Design of SERTlight: A Fluorescent Serotonin Probe for Neuronal Labeling in the Brain.

Journal

Journal of the American Chemical Society
ISSN: 1520-5126
Titre abrégé: J Am Chem Soc
Pays: United States
ID NLM: 7503056

Informations de publication

Date de publication:
01 Apr 2024
Historique:
medline: 1 4 2024
pubmed: 1 4 2024
entrez: 1 4 2024
Statut: aheadofprint

Résumé

The serotonergic transmitter system plays fundamental roles in the nervous system in neurotransmission, synaptic plasticity, pathological processes, and therapeutic effects of antidepressants and psychedelics, as well as in the gastrointestinal and circulatory systems. We introduce a novel small molecule fluorescent agent, termed

Identifiants

DOI: 10.1021/jacs.3c11617 PMID: 38557024
pubmed: 38557024
doi: 10.1021/jacs.3c11617
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Auteurs

Wei-Li Lee (WL)

Department of Chemistry, Columbia University, New York, New York 10027, United States.

Xavier Westergaard (X)

Department of Biological Sciences, Columbia University, New York, New York 10027, United States.
Department of Psychiatry, Columbia University Irving Medical Center, New York, New York 10032, United States.

Christopher Hwu (C)

Department of Chemistry, Columbia University, New York, New York 10027, United States.

Jennifer Hwu (J)

Department of Chemistry, Columbia University, New York, New York 10027, United States.

Tomas Fiala (T)

Department of Chemistry, Columbia University, New York, New York 10027, United States.
Laboratory of Organic Chemistry, ETH Zürich, D-CHAB, Vladimir-Prelog-Weg 3, 8093 Zürich, Switzerland.
ORCID: 0000-0001-6949-4561

Clay Lacefield (C)

Department of Psychiatry, Columbia University Irving Medical Center, New York, New York 10032, United States.
Division of Systems Neuroscience, New York State Psychiatric Institute, New York, New York 10032, United States.

Umed Boltaev (U)

Department of Chemistry, Columbia University, New York, New York 10027, United States.

Adriana M Mendieta (AM)

Department of Chemistry, Columbia University, New York, New York 10027, United States.

Lisa Lin (L)

Department of Psychiatry, Columbia University Irving Medical Center, New York, New York 10032, United States.
Department of Molecular Pharmacology and Therapeutics, Columbia University Irving Medical Center, New York, New York 10032, United States.

Mark S Sonders (MS)

Department of Psychiatry, Columbia University Irving Medical Center, New York, New York 10032, United States.
Division of Molecular Therapeutics, New York State Psychiatric Institute, New York, New York 10032, United States.

Keaon R Brown (KR)

Department of Chemistry, Columbia University, New York, New York 10027, United States.

Keer He (K)

Department of Chemistry, Columbia University, New York, New York 10027, United States.

Wesley B Asher (WB)

Department of Psychiatry, Columbia University Irving Medical Center, New York, New York 10032, United States.
Department of Molecular Pharmacology and Therapeutics, Columbia University Irving Medical Center, New York, New York 10032, United States.

Jonathan A Javitch (JA)

Department of Psychiatry, Columbia University Irving Medical Center, New York, New York 10032, United States.
Department of Molecular Pharmacology and Therapeutics, Columbia University Irving Medical Center, New York, New York 10032, United States.
Division of Molecular Therapeutics, New York State Psychiatric Institute, New York, New York 10032, United States.
ORCID: 0000-0001-7395-2967

David Sulzer (D)

Department of Psychiatry, Columbia University Irving Medical Center, New York, New York 10032, United States.
Department of Neurology, Columbia University Irving Medical Center, New York, New York 10032, United States.
Department of Molecular Pharmacology and Therapeutics, Columbia University Irving Medical Center, New York, New York 10032, United States.
Division of Molecular Therapeutics, New York State Psychiatric Institute, New York, New York 10032, United States.
ORCID: 0000-0001-7632-0439

Dalibor Sames (D)

Department of Chemistry, Columbia University, New York, New York 10027, United States.
Zuckerman Mind Brain Behavior Institute, Columbia University, New York, New York 10027, United States.
ORCID: 0000-0001-6911-2260

Classifications MeSH