Virucidal efficacy of hypochlorous acid water for aqueous phase and atomization against SARS-CoV-2.
atomization
coronavirus disease 2019 (COVID-19)
hypochlorous acid water (HOCl)
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
suspension test
Journal
Journal of water and health
ISSN: 1477-8920
Titre abrégé: J Water Health
Pays: England
ID NLM: 101185420
Informations de publication
Date de publication:
Mar 2024
Mar 2024
Historique:
received:
17
11
2023
accepted:
29
01
2024
medline:
1
4
2024
pubmed:
1
4
2024
entrez:
1
4
2024
Statut:
ppublish
Résumé
Coronavirus disease 2019 (COVID-19) is an infectious viral disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that emerged at the end of 2019. SARS-CoV-2 can be transmitted through droplets, aerosols, and fomites. Disinfectants such as alcohol, quaternary ammonium salts, and chlorine-releasing agents, including hypochlorous acid, are used to prevent the spread of SARS-CoV-2 infection. In the present study, we investigated the efficacy of ionless hypochlorous acid water (HOCl) in suspension and by spraying to inactivate SARS-CoV-2. The virucidal efficacy of HOCl solution in tests against SARS-CoV-2 was evaluated as 50% tissue culture infectious dose. Although the presence of organic compounds influenced the virucidal efficacy, HOCl treatment for 20 s was significantly effective to inactivate Wuhan and Delta strains in the suspension test. HOCl atomization for several hours significantly reduced the SARS-CoV-2 attached to plastic plates. These results indicate that HOCl solution with elimination containing NaCl and other ions may have high virucidal efficacy against SARS-CoV-2. This study provides important information about the virucidal efficacy and use of HOCl solution.
Identifiants
pubmed: 38557574
pii: wh_2024_348
doi: 10.2166/wh.2024.348
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
601-611Subventions
Organisme : Ministry of Health, Labour and Welfare
ID : 21HA2017
Informations de copyright
© 2024 The Authors This is an Open Access article distributed under the terms of the Creative Commons Attribution Licence (CC BY 4.0), which permits copying, adaptation and redistribution, provided the original work is properly cited (http://creativecommons.org/licenses/by/4.0/).
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