Advances in pediatric gliomas: from molecular characterization to personalized treatments.

Molecular characterization Pediatric gliomas Targeted therapies

Journal

European journal of pediatrics
ISSN: 1432-1076
Titre abrégé: Eur J Pediatr
Pays: Germany
ID NLM: 7603873

Informations de publication

Date de publication:
01 Apr 2024
Historique:
received: 01 01 2024
accepted: 21 03 2024
revised: 12 03 2024
medline: 1 4 2024
pubmed: 1 4 2024
entrez: 1 4 2024
Statut: aheadofprint

Résumé

Pediatric gliomas, consisting of both pediatric low-grade (pLGG) and high-grade gliomas (pHGG), are the most frequently occurring brain tumors in children. Over the last decade, several milestone advancements in treatments have been achieved as a result of stronger understanding of the molecular biology behind these tumors. This review provides an overview of pLGG and pHGG highlighting their clinical presentation, molecular characteristics, and latest advancements in therapeutic treatments.  Conclusion: The increasing understanding of the molecular biology characterizing pediatric low and high grade gliomas has revolutionized treatment options for these patients, especially in pLGG. The implementation of next generation sequencing techniques for these tumors is crucial in obtaining less toxic and more efficacious treatments. What is Known: • Pediatric Gliomas are the most common brain tumour in children. They are responsible for significant morbidity and mortality in this population. What is New: • Over the last two decades, there has been a significant increase in our global understanding of the molecular background of pediatric low and high grade gliomas. • The implementation of next generation sequencing techniques for these tumors is crucial in obtaining less toxic and more efficacious treatments, with the ultimate goal of improving both the survival and the quality of life of these patients.

Identifiants

pubmed: 38558313
doi: 10.1007/s00431-024-05540-4
pii: 10.1007/s00431-024-05540-4
doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.

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Auteurs

Sayanthen Sathyakumar (S)

Sunnybrook Research Institute, University of Toronto, Toronto, Ontario, Canada.

Matthew Martinez (M)

Department of Social Sciences, University of Ottawa, Ottawa, Ontario, Canada.

Sébastien Perreault (S)

Division of Pediatric Neurology, Department of Neurosciences, CHU Sainte-Justine, Montreal, Québec, Canada.

Geneviève Legault (G)

Department of Pediatrics, Division of Neurology, Montreal Children's Hospital - McGill University Health Center, Montreal, Québec, Canada.
The Research Institute of the McGill University Health Centre, Montreal, Québec, Canada.

Eric Bouffet (E)

The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.
Division of Haematology/Oncology, Department of Pediatrics, The Hospital for Sick Children, Toronto, Ontario, Canada.

Nada Jabado (N)

Division of Experimental Medicine, Montreal Children's Hospital, McGill University and McGill University Health Centre, Montreal, Québec, Canada.
Department of Pediatrics, McGill University, Montreal, Québec, Canada.

Valérie Larouche (V)

Division of Hemato-Oncology, Department of Pediatrics, CHU de Québec-Université Laval, 2705 Boulevard, Laurier, G1V 4G2, Québec, Canada.

Samuele Renzi (S)

Division of Hemato-Oncology, Department of Pediatrics, CHU de Québec-Université Laval, 2705 Boulevard, Laurier, G1V 4G2, Québec, Canada. Samuele.Renzi.med@ssss.gouv.qc.ca.

Classifications MeSH