The dynamin-related protein Dyn2 is essential for both apicoplast and mitochondrial fission in
Journal
bioRxiv : the preprint server for biology
Titre abrégé: bioRxiv
Pays: United States
ID NLM: 101680187
Informations de publication
Date de publication:
17 Mar 2024
17 Mar 2024
Historique:
medline:
1
4
2024
pubmed:
1
4
2024
entrez:
1
4
2024
Statut:
epublish
Résumé
Dynamins, or dynamin-related proteins (DRPs), are large mechano-sensitive GTPases mediating membrane dynamics or organellar fission/fusion events. PfDyn2 is essential for schizont-stage development.PfDyn2 mediates both apicoplast and mitochondrial fission.Deficiency of PfDyn2 leads to organellar fission failures and blockage of basal complex contraction.Addition of apicoplast-derived metabolite IPP does not rescue the growth defects.
Identifiants
pubmed: 38559241
doi: 10.1101/2024.03.15.585229
pmc: PMC10980034
pii:
doi:
Types de publication
Preprint
Langues
eng