Treatment switches of disease-modifying therapies in people with multiple sclerosis: long-term experience from the German MS Registry.
discontinuation
disease-modifying therapy
multiple sclerosis
switch
Journal
Therapeutic advances in neurological disorders
ISSN: 1756-2856
Titre abrégé: Ther Adv Neurol Disord
Pays: England
ID NLM: 101480242
Informations de publication
Date de publication:
2024
2024
Historique:
received:
27
06
2023
accepted:
14
02
2024
medline:
1
4
2024
pubmed:
1
4
2024
entrez:
1
4
2024
Statut:
epublish
Résumé
The spectrum of disease-modifying therapies (DMTs) for people with multiple sclerosis (PwMS) has expanded over years, but data on treatment strategies is largely lacking. DMT switches are common clinical practice. To compare switchers and non-switchers, characterize the first DMT switch and identify reasons and predictors for switching the first DMT. Data on 2722 PwMS from the German MS Registry were retrospectively analyzed regarding sociodemographic/clinical differences between 1361 switchers (PwMS discontinuing the first DMT) and non-switchers matched according to age, sex, and observation period. Frequencies of first and second DMTs were calculated and switch reasons identified. Predictors for DMT switches were revealed using univariable and multivariable regression models. Switchers and non-switchers differed significantly regarding time to first DMT, education, calendar period of the first DMT start (2014-2017 The initial use of MME DMTs was among the strongest predictors of DMT discontinuation in a large German retrospective MS cohort, arguing for the need for prospective treatment strategy trials, not only but also on the initial broad use of HE DMTs in PwMS.
Sections du résumé
Background
UNASSIGNED
The spectrum of disease-modifying therapies (DMTs) for people with multiple sclerosis (PwMS) has expanded over years, but data on treatment strategies is largely lacking. DMT switches are common clinical practice.
Objective
UNASSIGNED
To compare switchers and non-switchers, characterize the first DMT switch and identify reasons and predictors for switching the first DMT.
Methods
UNASSIGNED
Data on 2722 PwMS from the German MS Registry were retrospectively analyzed regarding sociodemographic/clinical differences between 1361 switchers (PwMS discontinuing the first DMT) and non-switchers matched according to age, sex, and observation period. Frequencies of first and second DMTs were calculated and switch reasons identified. Predictors for DMT switches were revealed using univariable and multivariable regression models.
Results
UNASSIGNED
Switchers and non-switchers differed significantly regarding time to first DMT, education, calendar period of the first DMT start (2014-2017
Conclusion
UNASSIGNED
The initial use of MME DMTs was among the strongest predictors of DMT discontinuation in a large German retrospective MS cohort, arguing for the need for prospective treatment strategy trials, not only but also on the initial broad use of HE DMTs in PwMS.
Identifiants
pubmed: 38560408
doi: 10.1177/17562864241239740
pii: 10.1177_17562864241239740
pmc: PMC10981260
doi:
Types de publication
Journal Article
Langues
eng
Pagination
17562864241239740Informations de copyright
© The Author(s), 2024.