Auditory oddball responses in the human subthalamic nucleus and substantia nigra pars reticulata.

Attention DBS Micro electrode recording Novelty Oddball Parkinson's disease SNr STN Surprise

Journal

Neurobiology of disease
ISSN: 1095-953X
Titre abrégé: Neurobiol Dis
Pays: United States
ID NLM: 9500169

Informations de publication

Date de publication:
30 Mar 2024
Historique:
received: 16 02 2024
revised: 24 03 2024
accepted: 29 03 2024
medline: 2 4 2024
pubmed: 2 4 2024
entrez: 1 4 2024
Statut: aheadofprint

Résumé

The auditory oddball is a mainstay in research on attention, novelty, and sensory prediction. How this task engages subcortical structures like the subthalamic nucleus and substantia nigra pars reticulata is unclear. We administered an auditory OB task while recording single unit activity (35 units) and local field potentials (57 recordings) from the subthalamic nucleus and substantia nigra pars reticulata of 30 patients with Parkinson's disease undergoing deep brain stimulation surgery. We found tone modulated and oddball modulated units in both regions. Population activity differentiated oddball from standard trials from 200 ms to 1000 ms after the tone in both regions. In the substantia nigra, beta band activity in the local field potential was decreased following oddball tones. The oddball related activity we observe may underlie attention, sensory prediction, or surprise-induced motor suppression.

Identifiants

DOI: 10.1016/j.nbd.2024.106490 PMID: 38561111
pubmed: 38561111
pii: S0969-9961(24)00089-5
doi: 10.1016/j.nbd.2024.106490
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

106490

Informations de copyright

Copyright © 2024. Published by Elsevier Inc.

Auteurs

Dallas Leavitt (D)

Institute of Biomedical Engineering, University of Toronto, Canada; University of Toronto - Max Planck Centre for Neural Science, University of Toronto, Canada; Krembil Brain Institute, University Health Network, Toronto, Canada.

Frhan I Alanazi (FI)

Krembil Brain Institute, University Health Network, Toronto, Canada; Department of Physiology, University of Toronto, Canada.

Tameem M Al-Ozzi (TM)

Krembil Brain Institute, University Health Network, Toronto, Canada; Department of Physiology, University of Toronto, Canada.

Melanie Cohn (M)

Krembil Brain Institute, University Health Network, Toronto, Canada.

Mojgan Hodaie (M)

Krembil Brain Institute, University Health Network, Toronto, Canada; Department of Surgery, University of Toronto, Canada; Division of Neurosurgery, Toronto Western Hospital - University Health Network, Toronto, Canada.

Suneil K Kalia (SK)

Krembil Brain Institute, University Health Network, Toronto, Canada; Department of Surgery, University of Toronto, Canada; Division of Neurosurgery, Toronto Western Hospital - University Health Network, Toronto, Canada.

Andres M Lozano (AM)

Krembil Brain Institute, University Health Network, Toronto, Canada; Department of Surgery, University of Toronto, Canada; Division of Neurosurgery, Toronto Western Hospital - University Health Network, Toronto, Canada.

Luka Milosevic (L)

Institute of Biomedical Engineering, University of Toronto, Canada; University of Toronto - Max Planck Centre for Neural Science, University of Toronto, Canada; Krembil Brain Institute, University Health Network, Toronto, Canada; Center for Advancing Neurotechnological Innovation to Application (CRANIA), Toronto, Canada; KITE Research Institute, University Health Network, Toronto, Canada.

William D Hutchison (WD)

Krembil Brain Institute, University Health Network, Toronto, Canada; Department of Physiology, University of Toronto, Canada; Department of Surgery, University of Toronto, Canada; Division of Neurosurgery, Toronto Western Hospital - University Health Network, Toronto, Canada. Electronic address: bill.hutchison@uhn.ca.

Classifications MeSH