Poor rhinitis and asthma control is associated with decreased health-related quality-of-life and utilities: A MASK-air study.

Allergic rhinitis Asthma EQ-5D-5L Health-related quality of life Mobile health Quality of life Real-world data Utilities

Journal

The journal of allergy and clinical immunology. In practice
ISSN: 2213-2201
Titre abrégé: J Allergy Clin Immunol Pract
Pays: United States
ID NLM: 101597220

Informations de publication

Date de publication:
30 Mar 2024
Historique:
received: 13 11 2023
revised: 15 02 2024
accepted: 21 03 2024
medline: 2 4 2024
pubmed: 2 4 2024
entrez: 1 4 2024
Statut: aheadofprint

Résumé

Allergic rhinitis (AR) and asthma may impact health-related quality-of-life. However, national estimates on the quality-of-life of patients with AR or asthma are lacking. To provide estimates for utility scores and EQ-5D Visual Analog Scale (VAS) for patients with AR or asthma. We conducted a cross-sectional study using direct patient data from the MASK-air® app on European MASK-air® users with self-reported AR or asthma. We used a multiattribute instrument (EQ-5D) to measure quality-of-life (as utility scores and EQ-5D VAS values). Mean scores were calculated per country and disease control level using multilevel regression models with post-stratification, accounting for age and sex biases. We assessed data from up to 7905 MASK-air® users reporting a total of up to 82,737 days. For AR, utilities ranged from 0.86-0.99 for good control versus 0.72-0.85 for poor control; EQ-5D VAS levels ranged from 78.9-87.9 for good control versus 55.3-64.2 for poor control. For asthma, utilities ranged from 0.84-0.97 for good control versus 0.73-0.87 for poor control; EQ-5D VAS levels ranged from 68.4-81.5 for good control versus 51.4-64.2 for poor control. Poor disease control was associated with a mean loss of 0.14 utilities for both AR and asthma. For the same control levels, AR and asthma were associated with similar utilities and EQ-5D VAS levels. However, lower values were observed for asthma+AR when compared to AR alone. Poor AR or asthma control are associated with reduced quality-of-life. The estimates obtained from mHealth data may provide valuable insights for health technology assessment studies.

Sections du résumé

BACKGROUND BACKGROUND
Allergic rhinitis (AR) and asthma may impact health-related quality-of-life. However, national estimates on the quality-of-life of patients with AR or asthma are lacking.
OBJECTIVE OBJECTIVE
To provide estimates for utility scores and EQ-5D Visual Analog Scale (VAS) for patients with AR or asthma.
METHODS METHODS
We conducted a cross-sectional study using direct patient data from the MASK-air® app on European MASK-air® users with self-reported AR or asthma. We used a multiattribute instrument (EQ-5D) to measure quality-of-life (as utility scores and EQ-5D VAS values). Mean scores were calculated per country and disease control level using multilevel regression models with post-stratification, accounting for age and sex biases.
RESULTS RESULTS
We assessed data from up to 7905 MASK-air® users reporting a total of up to 82,737 days. For AR, utilities ranged from 0.86-0.99 for good control versus 0.72-0.85 for poor control; EQ-5D VAS levels ranged from 78.9-87.9 for good control versus 55.3-64.2 for poor control. For asthma, utilities ranged from 0.84-0.97 for good control versus 0.73-0.87 for poor control; EQ-5D VAS levels ranged from 68.4-81.5 for good control versus 51.4-64.2 for poor control. Poor disease control was associated with a mean loss of 0.14 utilities for both AR and asthma. For the same control levels, AR and asthma were associated with similar utilities and EQ-5D VAS levels. However, lower values were observed for asthma+AR when compared to AR alone.
CONCLUSION CONCLUSIONS
Poor AR or asthma control are associated with reduced quality-of-life. The estimates obtained from mHealth data may provide valuable insights for health technology assessment studies.

Identifiants

DOI: 10.1016/j.jaip.2024.03.036 PMID: 38561141
pubmed: 38561141
pii: S2213-2198(24)00329-5
doi: 10.1016/j.jaip.2024.03.036
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Investigateurs

Wienczyslawa Czarlewski (W)
Anna Bedbrook (A)
Tari Haahtela (T)
G Walter Canonica (GW)
Elisio M Costa (EM)
Maciej Kupczyk (M)
Violeta Kvedariene (V)
Marek Kulus (M)
Désirée E Larenas-Linnemann (DE)
Oliver Pfaar (O)
Nikolaos G Papadopoulos (NG)
Nhân Pham-Thi (N)
Frederico S Regateiro (FS)
Nicolas Roche (N)
Joaquin Sastre (J)
Nicola Scichilone (N)
Luis Taborda-Barata (L)
Arunas Valiulis (A)
Arzu Yorgancioglu (A)
Maria Teresa Ventura (MT)
Rute Almeida (R)
Rita Amaral (R)
Ignacio J Ansotegui (IJ)
Karl C Bergmann (KC)
Sinthia Bosnic-Anticevich (S)
Fulvio Braido (F)
Luisa Brussino (L)
Victoria Cardona (V)
Lorenzo Cecchi (L)
Claudia Chaves Loureiro (CC)
Cemal Cingi (C)
Alvaro A Cruz (AA)
Wytske J Fokkens (WJ)
Govert de Vries (G)
Bilun Gemicioglu (B)
Antonio Fm Giuliana (AF)
Tomohisa Linuma (T)
Juan Carlos Ivancevich (JC)
Cristina Jácome (C)
Igor Kaidashev (I)
Helga Kraxner (H)
Daniel Laune (D)
Gilles Louis (G)
Olga Lourenço (O)
Mika Makela (M)
Michael Makris (M)
Ralph Mösges (R)
Marcus Maurer (M)
Joaquim Mullol (J)
Rachel Nadif (R)
Marek Niedoszytko (M)
Robyn O'Hehir (R)
Yoshitaka Okamoto (Y)
Markus Ollert (M)
Heidi Olze (H)
Vincenzo Patella (V)
Benoit Pétré (B)
Francesca Puggioni (F)
Jan Romantowski (J)
Philip W Rouadi (PW)
Sietze Reitsma (S)
Daniela Rivero-Yeverino (D)
Monica Rodriguez-Gonzalez (M)
Ana Sá-Sousa (A)
Faradiba S Serpa (FS)
Mohamed H Shamji (MH)
Aziz Sheikh (A)
Charlotte Suppli Ulrik (CS)
Mikhail Sofiev (M)
Milan Sova (M)
Annette Sperl (A)
Ana Todo-Bom (A)
Peter V Tomazic (PV)
Sanna Toppila-Salmi (S)
Ioanna Tsiligianni (I)
Erkka Valovirta (E)
Michiel van Eerd (M)
Mihaela Zidarn (M)
Hubert Blain (H)
Louis-Philippe Boulet (LP)
Guy Brusselle (G)
Roland Buhl (R)
Denis Charpin (D)
Thomas Casale (T)
Tomas Chivato (T)
Jaime Correia-de-Sousa (J)
Christopher Corrigan (C)
Frédéric de Blay (F)
Stefano Del Giacco (S)
Philippe Devillier (P)
Mark Dykewicz (M)
Alessandro Fiocchi (A)
Mattia Giovannini (M)
Ewa Jassem (E)
Marek Jutel (M)
Thomas Keil (T)
Stefania La Grutta (S)
Brian Lipworth (B)
Alberto Papi (A)
Jean-Louis Pépin (JL)
Santiago Quirce (S)
Carlos Robalo Cordeiro (CR)
Maria J Torres (MJ)
Omar S Usmani (OS)

Informations de copyright

Copyright © 2024. Published by Elsevier Inc.

Auteurs

Rafael José Vieira (RJ)

Department of Community Medicine, Information and Health Decision Sciences (MEDCIDS), Faculty of Medicine, University of Porto, Porto, Portugal; Centre for Health Technology and Services Research, Health Research Network (CINTESIS@RISE), Faculty of Medicine, University of Porto, Porto, Portugal.

Lucas Leemann (L)

Department of Political Science, University of Zurich, Zurich, Switzerland.

Andrew Briggs (A)

Department of Health Services Research and Policy, London School of Hygiene and Tropical Medicine, London, United Kingdom.

Ana Margarida Pereira (AM)

Department of Community Medicine, Information and Health Decision Sciences (MEDCIDS), Faculty of Medicine, University of Porto, Porto, Portugal; Centre for Health Technology and Services Research, Health Research Network (CINTESIS@RISE), Faculty of Medicine, University of Porto, Porto, Portugal.

Marine Savouré (M)

Inserm, Equipe d'Epidémiologie Respiratoire Intégrative, CESP, Villejuif, France; Université Paris-Saclay, UVSQ, Université Paris-Sud, Villejuif, France.

Piotr Kuna (P)

Division of Internal Medicine, Asthma and Allergy, Barlicki University Hospital, Medical University of Lodz, Lodz, Poland.

Mário Morais-Almeida (M)

Allergy Center, CUF Descobertas Hospital, Lisbon, Portugal.

Michael Bewick (M)

University of Central Lancashire Medical School, Preston, United Kingdom.

Luís Filipe Azevedo (LF)

Department of Community Medicine, Information and Health Decision Sciences (MEDCIDS), Faculty of Medicine, University of Porto, Porto, Portugal; Centre for Health Technology and Services Research, Health Research Network (CINTESIS@RISE), Faculty of Medicine, University of Porto, Porto, Portugal.

Renaud Louis (R)

Department of Pulmonary Medicine, CHU Liège, Liège, Belgium; GIGA I3 Research Group, University of Liège, Liège, Belgium.

Ludger Klimek (L)

Department of Otolaryngology, Head and Neck Surgery, Universitätsmedizin Mainz, Mainz, Germany; Center for Rhinology and Allergology, Wiesbaden, Germany.

Farah Bahbah (F)

Stallergenes Greer Ltd, Antony, France.

Boleslaw Samolinski (B)

Department of Prevention of Environmental Hazards, Allergology and Immunology, Medical University of Warsaw, Warsaw, Poland.

Josep M Anto (JM)

ISGlobal, Barcelona Institute for Global Health, Barcelona, Spain; Universitat Pompeu Fabra (UPF), Barcelona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain.

Torsten Zuberbier (T)

Institute of Allergology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Allergology and Immunology, Berlin, Germany.

João A Fonseca (JA)

Department of Community Medicine, Information and Health Decision Sciences (MEDCIDS), Faculty of Medicine, University of Porto, Porto, Portugal; Centre for Health Technology and Services Research, Health Research Network (CINTESIS@RISE), Faculty of Medicine, University of Porto, Porto, Portugal.

Jean Bousquet (J)

Institute of Allergology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Allergology and Immunology, Berlin, Germany; MASK-air SAS, Montpellier, France. Electronic address: jean.bousquet@orange.fr.

Bernardo Sousa-Pinto (B)

Department of Community Medicine, Information and Health Decision Sciences (MEDCIDS), Faculty of Medicine, University of Porto, Porto, Portugal; Centre for Health Technology and Services Research, Health Research Network (CINTESIS@RISE), Faculty of Medicine, University of Porto, Porto, Portugal.

Classifications MeSH