Metabolic priming of GD2
Journal
bioRxiv : the preprint server for biology
Titre abrégé: bioRxiv
Pays: United States
ID NLM: 101680187
Informations de publication
Date de publication:
19 Mar 2024
19 Mar 2024
Historique:
medline:
2
4
2024
pubmed:
2
4
2024
entrez:
2
4
2024
Statut:
epublish
Résumé
Manufacturing Chimeric Antigen Receptor (CAR) T cell therapies is complex, with limited understanding of how media composition impact T-cell phenotypes. CRISPR/Cas9 ribonucleoproteins can precisely insert a CAR sequence while disrupting the endogenous T cell receptor alpha constant (
Identifiants
pubmed: 38562720
doi: 10.1101/2024.01.31.575774
pmc: PMC10983869
pii:
doi:
Types de publication
Preprint
Langues
eng