Imbalance in glucose metabolism regulates the transition of microglia from homeostasis to Disease Associated Microglia stage 1.

Journal

The Journal of neuroscience : the official journal of the Society for Neuroscience
ISSN: 1529-2401
Titre abrégé: J Neurosci
Pays: United States
ID NLM: 8102140

Informations de publication

Date de publication:
02 Apr 2024
Historique:
received: 16 08 2023
revised: 21 03 2024
accepted: 23 03 2024
medline: 3 4 2024
pubmed: 3 4 2024
entrez: 2 4 2024
Statut: aheadofprint

Résumé

Microglia undergo two-stage activation in neurodegenerative diseases, known as disease-associated microglia (DAM). TREM2 mediates the DAM2 stage transition, but what regulates the first DAM1 stage transition is unknown. We report that glucose dyshomeostasis inhibits DAM1 activation, and PKM2 plays a role. As in tumors, PKM2 was aberrantly elevated in both male and female human AD brains, but unlike in tumors, it is expressed as active tetramers, as well as among TREM2

Identifiants

DOI: 10.1523/JNEUROSCI.1563-23.2024 PMID: 38565291
pubmed: 38565291
pii: JNEUROSCI.1563-23.2024
doi: 10.1523/JNEUROSCI.1563-23.2024
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

Copyright © 2024 the authors.

Auteurs

Yuxi Liu (Y)

Department of Biological Chemistry and Pharmacology, The Ohio State University, Columbus, OH, USA.

Witty Kwok (W)

Department of Biological Chemistry and Pharmacology, The Ohio State University, Columbus, OH, USA.

Hyojung Yoon (H)

Department of Neuroscience, The Ohio State University, Columbus, OH, USA.

Jae Cheon Ryu (JC)

Department of Biological Chemistry and Pharmacology, The Ohio State University, Columbus, OH, USA.

Patrick Stevens (P)

Department of Biomedical Informatics, The Ohio State University, Columbus, OH, USA.

Tara R Hawkinson (TR)

Department of Biochemistry and Molecular Biology, College of Medicine, University of Florida, Gainesville, FL, USA.
Center for Advanced Spatial Biomolecule Research, University of Florida, Gainesville, FL, 32610, USA.

Cameron J Shedlock (CJ)

Department of Biochemistry and Molecular Biology, College of Medicine, University of Florida, Gainesville, FL, USA.
Center for Advanced Spatial Biomolecule Research, University of Florida, Gainesville, FL, 32610, USA.

Roberto A Ribas (RA)

Department of Biochemistry and Molecular Biology, College of Medicine, University of Florida, Gainesville, FL, USA.
Center for Advanced Spatial Biomolecule Research, University of Florida, Gainesville, FL, 32610, USA.

Terrymar Medina (T)

Department of Biochemistry and Molecular Biology, College of Medicine, University of Florida, Gainesville, FL, USA.
Center for Advanced Spatial Biomolecule Research, University of Florida, Gainesville, FL, 32610, USA.

Shannon B Keohane (SB)

Department of Biochemistry and Molecular Biology, College of Medicine, University of Florida, Gainesville, FL, USA.
Center for Advanced Spatial Biomolecule Research, University of Florida, Gainesville, FL, 32610, USA.

Douglas Scharre (D)

Department of Neurology, The Ohio State University, Columbus, OH, USA.

Lei Bruschweiler-Li (L)

Department of Chemistry and Biochemistry, The Ohio State University, Columbus, OH, USA.

Rafael Bruschweiler (R)

Department of Chemistry and Biochemistry, The Ohio State University, Columbus, OH, USA.

Alban Gaultier (A)

Center for Brain Immunology and Glia, University of Virginia, Charlottesville, VA, 22908, USA.

Karl Obrietan (K)

Department of Neuroscience, The Ohio State University, Columbus, OH, USA.

Ramon C Sun (RC)

Department of Biochemistry and Molecular Biology, College of Medicine, University of Florida, Gainesville, FL, USA.
Center for Advanced Spatial Biomolecule Research, University of Florida, Gainesville, FL, 32610, USA.

Sung Ok Yoon (SO)

Department of Biological Chemistry and Pharmacology, The Ohio State University, Columbus, OH, USA. Sung.yoon@osumc.edu.

Classifications MeSH