The diagnostic yield of inferior petrosal sinus sampling in Cushing syndrome in the era of ovine CRH shortage.
Cushing’s syndrome
Drug shortages
Petrosal sinus sampling
oCRH stimulation
Journal
Acta neurochirurgica
ISSN: 0942-0940
Titre abrégé: Acta Neurochir (Wien)
Pays: Austria
ID NLM: 0151000
Informations de publication
Date de publication:
03 Apr 2024
03 Apr 2024
Historique:
received:
21
12
2023
accepted:
25
03
2024
medline:
3
4
2024
pubmed:
3
4
2024
entrez:
2
4
2024
Statut:
epublish
Résumé
The ovine corticotropin-releasing hormone (oCRH) stimulation test has been routinely used in the diagnostic work-up of ACTH-dependent Cushing syndrome (CS). With oCRH currently being out-of-stock in Europe, we aimed at evaluating the diagnostic performance of inferior petrosal sinus sampling (IPSS) without oCRH stimulation. We compared the values of 40 patients with ACTH-dependent CS and negative MRI findings in whom ACTH was measured before and after oCRH stimulation. The ratio of central-to-peripheral ACTH measurement (IPS:P) before the combined 3, 5, and 10 min of oCRH stimulation yielded diminished sensitivity (85% vs. 97%), alongside markedly decreased specificity (57% vs. 71%), as well as reduced positive and negative predictive values (90% vs. 94% and 44% vs. 83%), respectively. With the current drug shortages in Europe, ACTH measurements without oCRH stimulation in IPSS cannot be recommended. Thus, we call for desmopressin or the commercially available human CRH as a potential alternative in the confirmation of ACTH excess by IPSS in equivocal MRI findings.
Identifiants
pubmed: 38565838
doi: 10.1007/s00701-024-06058-2
pii: 10.1007/s00701-024-06058-2
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
167Informations de copyright
© 2024. The Author(s).
Références
Andereggen L, Schroth G, Gralla J, Seiler R, Mariani L, Beck J, Widmer HR, Andres RH, Christ E, Ozdoba C (2012) Selective inferior petrosal sinus sampling without venous outflow diversion in the detection of a pituitary adenoma in Cushing’s syndrome. Neuroradiology 54:495–503. https://doi.org/10.1007/s00234-011-0915-6
doi: 10.1007/s00234-011-0915-6
pubmed: 21808987
Andereggen L, Mariani L, Beck J, Andres RH, Gralla J, Luedi MM, Weis J, Christ E (2021) Lateral one-third gland resection in Cushing patients with failed adenoma identification leads to low remission rates: long-term observations from a small, single-center cohort. Acta Neurochir 163:3161–3169. https://doi.org/10.1007/s00701-021-04830-2
doi: 10.1007/s00701-021-04830-2
pubmed: 33811521
Andereggen L, Frey J, Andres RH, Luedi MM, El-Koussy M, Widmer HR, Beck J, Mariani L, Seiler RW, Christ E (2021) First-line surgery in prolactinomas: lessons from a long-term follow-up study in a tertiary referral center. J Endocrinol Invest 44:2621–2633. https://doi.org/10.1007/s40618-021-01569-6
doi: 10.1007/s40618-021-01569-6
pubmed: 33847973
pmcid: 8572196
Andereggen L, Gralla J, Schroth G, Mordasini P, Andres RH, Widmer HR, Luedi MM, Kellner F, Beck J, Mariani L, Ozdoba C, Christ E (2021) Influence of inferior petrosal sinus drainage symmetry on detection of adenomas in Cushing’s syndrome. J Neuroradiol 48:10–15. https://doi.org/10.1016/j.neurad.2019.05.004
doi: 10.1016/j.neurad.2019.05.004
pubmed: 31228539
Andereggen L, Frey J, Andres RH, Luedi MM, Gralla J, Schubert GA, Beck J, Mariani L, Christ E (2021) Impact of primary medical or surgical therapy on prolactinoma patients’ BMI and metabolic profile over the long-term. J Clin Transl Endocrinol 24:100258. https://doi.org/10.1016/j.jcte.2021.100258
doi: 10.1016/j.jcte.2021.100258
pubmed: 34195008
pmcid: 8237353
Andereggen L, Frey J, Andres RH, Luedi MM, Widmer HR, Beck J, Mariani L, Christ E (2021) Persistent bone impairment despite long-term control of hyperprolactinemia and hypogonadism in men and women with prolactinomas. Sci Rep 11:5122. https://doi.org/10.1038/s41598-021-84606-x
doi: 10.1038/s41598-021-84606-x
pubmed: 33664388
pmcid: 7933248
Andereggen L, Tortora A, Schubert GA, Musahl C, Frey J, Luedi MM, Mariani L, Beck J, Christ E (2023) Prolactinomas in adolescent and elderly patients-a comparative long-term analysis. Front Surg 10:967407. https://doi.org/10.3389/fsurg.2023.967407
doi: 10.3389/fsurg.2023.967407
pubmed: 36814862
pmcid: 9939754
Benndorf G, Campi A (2002) Aberrant inferior petrosal sinus: unusual transvenous approach to the cavernous sinus. Neuroradiology 44:158–163
doi: 10.1007/s002340100659
pubmed: 11942369
Berkmann S, Roethlisberger M, Mueller B, Christ-Crain M, Mariani L, Nitzsche E, Juengling F (2021) Selective resection of cushing microadenoma guided by preoperative hybrid 18-fluoroethyl-L-tyrosine and 11-C-methionine PET/MRI. Pituitary 24:878–886. https://doi.org/10.1007/s11102-021-01160-5
doi: 10.1007/s11102-021-01160-5
pubmed: 34155554
Bertherat J (2021) CRH-receptor molecular imaging reveals the intimacy of corticotroph adenomas. J Clin Endocrinol Metab 106:e1902–e1904. https://doi.org/10.1210/clinem/dgaa883
doi: 10.1210/clinem/dgaa883
pubmed: 33382418
Bonelli FS, Huston J 3rd, Carpenter PC, Erickson D, Young WF Jr, Meyer FB (2000) Adrenocorticotropic hormone-dependent Cushing’s syndrome: sensitivity and specificity of inferior petrosal sinus sampling. AJNR Am J Neuroradiol 21:690–696
pubmed: 10782779
pmcid: 7976629
Booth GL, Redelmeier DA, Grosman H, Kovacs K, Smyth HS, Ezzat S (1998) Improved diagnostic accuracy of inferior petrosal sinus sampling over imaging for localizing pituitary pathology in patients with Cushing’s disease. J Clin Endocrinol Metab 83:2291–2295. https://doi.org/10.1210/jcem.83.7.4956
doi: 10.1210/jcem.83.7.4956
pubmed: 9661597
Castinetti F, Morange I, Dufour H, Jaquet P, Conte-Devolx B, Girard N, Brue T (2007) Desmopressin test during petrosal sinus sampling: a valuable tool to discriminate pituitary or ectopic ACTH-dependent Cushing’s syndrome. Eur J Endocrinol/Eur Fed Endocr Soc 157:271–277. https://doi.org/10.1530/EJE-07-0215
doi: 10.1530/EJE-07-0215
Cristante J, Lefournier V, Sturm N, Passagia JG, Gauchez AS, Tahon F, Cantin S, Chabre O, Gay E (2019) Why we should still treat by neurosurgery patients with Cushing’s disease and a normal or inconclusive pituitary MRI. J Clin Endocrinol Metab. https://doi.org/10.1210/jc.2019-00333
doi: 10.1210/jc.2019-00333
pubmed: 31276157
de Rotte AA, Groenewegen A, Rutgers DR, Witkamp T, Zelissen PM, Meijer FJ, van Lindert EJ, Hermus A, Luijten PR, Hendrikse J (2016) High resolution pituitary gland MRI at 7.0 tesla: a clinical evaluation in Cushing’s disease. Eur Radiol 26:271–277. https://doi.org/10.1007/s00330-015-3809-x
doi: 10.1007/s00330-015-3809-x
pubmed: 25991481
Detomas M, Ritzel K, Nasi-Kordhishti I, Schernthaner-Reiter MH, Losa M, Troger V, Altieri B, Kroiss M, Kickuth R, Fassnacht M, Micko A, Honegger J, Reincke M, Deutschbein T (2023) Bilateral inferior petrosal sinus sampling with human CRH stimulation in ACTH-dependent Cushing’s syndrome: results from a retrospective multicenter study. Eur J Endocrinol/Eur Fed Endocr Soc. https://doi.org/10.1093/ejendo/lvad050
doi: 10.1093/ejendo/lvad050
Graham KE, Samuels MH, Nesbit GM, Cook DM, O’Neill OR, Barnwell SL, Loriaux DL (1999) Cavernous sinus sampling is highly accurate in distinguishing Cushing’s disease from the ectopic adrenocorticotropin syndrome and in predicting intrapituitary tumor location. J Clin Endocrinol Metab 84:1602–1610. https://doi.org/10.1210/jcem.84.5.5654
doi: 10.1210/jcem.84.5.5654
pubmed: 10323387
Huber M, Luedi MM, Schubert GA, Musahl C, Tortora A, Frey J, Beck J, Mariani L, Christ E, Andereggen L (2022) Machine learning for outcome prediction in first-line surgery of prolactinomas. Front Endocrinol (Lausanne) 13:810219. https://doi.org/10.3389/fendo.2022.810219
doi: 10.3389/fendo.2022.810219
pubmed: 35250868
Huber M, Luedi MM, Schubert GA, Musahl C, Tortora A, Frey J, Beck J, Mariani L, Christ E, Andereggen L (2024) Gender-specific prolactin thresholds to determine prolactinoma size: a novel Bayesian approach and its clinical utility. Front Surg 11:1363431. https://doi.org/10.3389/fsurg.2024.1363431
doi: 10.3389/fsurg.2024.1363431
pubmed: 38544490
pmcid: 10966909
Lonser RR, Nieman L, Oldfield EH (2017) Cushing’s disease: pathobiology, diagnosis, and management. J Neurosurg 126:404–417. https://doi.org/10.3171/2016.1.JNS152119
doi: 10.3171/2016.1.JNS152119
pubmed: 27104844
Oldfield EH, Chrousos GP, Schulte HM, Schaaf M, McKeever PE, Krudy AG, Cutler GB Jr, Loriaux DL, Doppman JL (1985) Preoperative lateralization of ACTH-secreting pituitary microadenomas by bilateral and simultaneous inferior petrosal venous sinus sampling. N Engl J Med 312:100–103
doi: 10.1056/NEJM198501103120207
pubmed: 2981108
Oldfield EH, Doppman JL, Nieman LK, Chrousos GP, Miller DL, Katz DA, Cutler GB Jr, Loriaux DL (1991) Petrosal sinus sampling with and without corticotropin-releasing hormone for the differential diagnosis of Cushing’s syndrome. N Engl J Med 325:897–905
doi: 10.1056/NEJM199109263251301
pubmed: 1652686
Oldfield EH, Vance ML, Louis RG, Pledger CL, Jane JA Jr, Lopes MB (2015) Crooke’s changes in Cushing’s syndrome depends on degree of hypercortisolism and individual susceptibility. J Clin Endocrinol Metab 100:3165–3171. https://doi.org/10.1210/JC.2015-2493
doi: 10.1210/JC.2015-2493
pubmed: 26147609
Patel V, Liu CJ, Shiroishi MS, Hurth K, Carmichael JD, Zada G, Toga AW (2020) Ultra-high field magnetic resonance imaging for localization of corticotropin-secreting pituitary adenomas. Neuroradiology 62:1051–1054. https://doi.org/10.1007/s00234-020-02431-x
doi: 10.1007/s00234-020-02431-x
pubmed: 32306052
Pecori Giraldi F, Cavallo LM, Tortora F, Pivonello R, Colao A, Cappabianca P, Mantero F, Altogether to Beat Cushing’s Syndrome G (2015) The role of inferior petrosal sinus sampling in ACTH-dependent Cushing’s syndrome: review and joint opinion statement by members of the Italian Society for Endocrinology, Italian Society for Neurosurgery, and Italian Society for Neuroradiology. Neurosurg Focus 38:E5. https://doi.org/10.3171/2014.11.FOCUS14766
doi: 10.3171/2014.11.FOCUS14766
pubmed: 25639323
Shiu PC, Hanafee WN, Wilson GH, Rand RW (1968) Cavernous sinus venography. Am J Roentgenol Radium Ther Nucl Med 104:57–62
doi: 10.2214/ajr.104.1.57
pubmed: 5672775
Tabarin A, Greselle JF, San-Galli F, Leprat F, Caille JM, Latapie JL, Guerin J, Roger P (1991) Usefulness of the corticotropin-releasing hormone test during bilateral inferior petrosal sinus sampling for the diagnosis of Cushing’s disease. J Clin Endocrinol Metab 73:53–59. https://doi.org/10.1210/jcem-73-1-53
doi: 10.1210/jcem-73-1-53
pubmed: 1646218
Valizadeh M, Ahmadi AR, Ebadinejad A, Rahmani F, Abiri B (2022) Diagnostic accuracy of bilateral inferior petrosal sinus sampling using desmopressin or corticotropic- releasing hormone in ACTH-dependent Cushing’s syndrome: a systematic review and meta-analysis. Rev Endocr Metab Disord 23:881–892. https://doi.org/10.1007/s11154-022-09723-y
doi: 10.1007/s11154-022-09723-y
pubmed: 35478451
Walia R, Gupta R, Bhansali A, Pivonello R, Kumar R, Singh H, Ahuja C, Chhabra R, Singh A, Dhandapani S, Sahoo S, Rana N, Vatsa R, Dutta P, Kumar Bhadada S, Sachdeva N, Mittal BR, Nahar U, Shukla J (2021) Molecular imaging targeting corticotropin-releasing hormone receptor for corticotropinoma: a changing paradigm. J Clin Endocrinol Metab 106:e1816–e1826. https://doi.org/10.1210/clinem/dgaa755
doi: 10.1210/clinem/dgaa755
pubmed: 33079979
Wind JJ, Lonser RR, Nieman LK, DeVroom HL, Chang R, Oldfield EH (2013) The lateralization accuracy of inferior petrosal sinus sampling in 501 patients with Cushing’s disease. J Clin Endocrinol Metab 98:2285–2293. https://doi.org/10.1210/jc.2012-3943
doi: 10.1210/jc.2012-3943
pubmed: 23553862
pmcid: 3667263