Kidney transplant in pediatric gut transplant recipients - Technical challenges and outcomes.
gut transplantation
intestinal failure
liver/intestine transplant
pediatric kidney transplant
pediatric transplantation
Journal
Pediatric transplantation
ISSN: 1399-3046
Titre abrégé: Pediatr Transplant
Pays: Denmark
ID NLM: 9802574
Informations de publication
Date de publication:
May 2024
May 2024
Historique:
revised:
20
02
2024
received:
04
09
2023
accepted:
05
03
2024
medline:
3
4
2024
pubmed:
3
4
2024
entrez:
3
4
2024
Statut:
ppublish
Résumé
There is limited data in the literature about pediatric kidney transplant (KT) following gut transplant (GT). The purpose of this study is to highlight the technical challenges and outcomes of KT in pediatric gut recipients who developed kidney failure (KF). A retrospective single-center study of pediatric GT recipients from January 2000 to December 2019 was performed. In total, 14 (7%) out of 206 pediatric GT recipients developed KF and were listed for KT. Ten patients underwent kidney after gut transplant (KAGT), three patients underwent simultaneous kidney and re-do gut transplant (SKAGT), and one patient died on the KT waitlist. 1-, 5-, and 10-year kidney graft survival was 100%, 91%, and 78%, respectively. 1-, 5-, and 10-year GT graft survival was 100%, 77%, and 77%, respectively. 1-, 5-, and 10-year patient survival was 100%, 91%, and 91%, respectively. Despite the technical complexity, KAGT and SKAGT for pediatric GT recipients that develop KF can be performed with favorable outcomes.
Sections du résumé
BACKGROUND
BACKGROUND
There is limited data in the literature about pediatric kidney transplant (KT) following gut transplant (GT). The purpose of this study is to highlight the technical challenges and outcomes of KT in pediatric gut recipients who developed kidney failure (KF).
METHODS
METHODS
A retrospective single-center study of pediatric GT recipients from January 2000 to December 2019 was performed. In total, 14 (7%) out of 206 pediatric GT recipients developed KF and were listed for KT. Ten patients underwent kidney after gut transplant (KAGT), three patients underwent simultaneous kidney and re-do gut transplant (SKAGT), and one patient died on the KT waitlist.
RESULTS
RESULTS
1-, 5-, and 10-year kidney graft survival was 100%, 91%, and 78%, respectively. 1-, 5-, and 10-year GT graft survival was 100%, 77%, and 77%, respectively. 1-, 5-, and 10-year patient survival was 100%, 91%, and 91%, respectively.
CONCLUSION
CONCLUSIONS
Despite the technical complexity, KAGT and SKAGT for pediatric GT recipients that develop KF can be performed with favorable outcomes.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e14744Informations de copyright
© 2024 Wiley Periodicals LLC.
Références
Raghu VK, Beaumont JL, Everly MJ, Venick RS, Lacaille F, Mazariegos GV. Pediatric intestinal transplantation: analysis of the intestinal transplant registry. Pediatr Transplant. 2019;23(8):e13580. doi:10.1111/petr.13580
Ojo AO, Held PJ, Port FK, et al. Chronic renal failure after transplantation of a nonrenal organ. N Engl J Med. 2003;349:931‐940.
Puttarajappa CM, Hariharan S, Humar A, et al. Outcomes of adult intestinal transplant recipients requiring dialysis and renal transplantation. Transplant Direct. 2018;4(8):e377. doi:10.1097/TXD.0000000000000815
Soltys KA, Bond G, Sindhi R, et al. Pediatric intestinal transplantation. Semin Pediatr Surg. 2017;26(4):241‐249.
Schwartz GJ, Work DF. Measurement and estimation of GFR in children and adolescents. J Am Soc Nephrol. 2009;4(11):1832‐1843.
Candice R, Simmonds N, Clahsen‐van Groningen M, et al. A 2018 Reference Guide to the Banff classification of renal allograft pathology. Transplantation. 2018;102(11):1795‐1814. doi:10.1097/TP.0000000000002366
Abu‐Elmagd KM, Kosmach‐Park B, Costa G, et al. Long‐term survival, nutritional autonomy, and quality of life after intestinal and multivisceral transplantation. Ann Surg. 2012;256(3):494‐508. doi:10.1097/SLA.0b013e318265f310
Ylinen E, Merra‐Salmio L, Gunnar R, et al. Intestinal failure as a significant risk factor for renal impairment in children. Nutrition. 2018;45:90‐93. doi:10.1016/j.nut.2017.07.011
Horslen S, Torres C, Collier D, et al. Initial experience using rapamycin immunosuppression in pediatric intestine transplant recipients. Transplant Proc. 2002;34(3):934‐935. doi:10.1016/s0041-1345(02)02677-5
Andres AM, Santamaria ML, Ramos E, et al. The use of sirolimus as a rescue therapy in pediatric intestine transplant recipients. Pediatr Transplant. 2010;14(7):931‐935. doi:10.1111/j.1399-3046.2010.01363.x
Hart A, Smith JM, Skeans MA, et al. OPTN/SRTR 2017 annual data report: kidney. Am J Transplant. 2019;19(Suppl 2):19‐123. doi:10.1111/ajt.15274