Is the leptin/BMI ratio a reliable biomarker for endometriosis?

endometriosis infertility leptin peritoneal fluid plasma

Journal

Frontiers in endocrinology
ISSN: 1664-2392
Titre abrégé: Front Endocrinol (Lausanne)
Pays: Switzerland
ID NLM: 101555782

Informations de publication

Date de publication:
2024
Historique:
received: 20 12 2023
accepted: 04 03 2024
medline: 3 4 2024
pubmed: 3 4 2024
entrez: 3 4 2024
Statut: epublish

Résumé

The aim of this study was to analyze the concentration of leptin in peritoneal fluid and plasma and to assess their role as potential biomarkers in the diagnosis of endometriosis. Leptin adjusted for BMI (leptin/BMI ratio) was measured using surface plasmon resonance imaging (SPRI) biosensors. Patients with suspected endometriosis were included in the study. Plasma was collected from 70 cases, and peritoneal fluid from 67 cases. Based on the presence of endometriosis lesions detected during laparoscopy, patients were divided into a study group and a control group (patients without endometriosis). Leptin/BMI ratio in plasma did not differ between women with endometriosis and the control group (0.7159 ± 0.259 vs 0.6992 ± 0.273, p= 0,7988). No significant differences were observed in peritoneal leptin/BMI ratio levels in patients with and without endometriosis (0.6206 ± 0.258 vs 0.6215 ± 0.264, p= 0,9896). Plasma and peritoneal leptin/BMI ratios were significantly lower in women with endometriosis - related primary infertility compared to women with endometriosis without primary infertility (0.640 ± 0.502 vs 0.878 ± 0.623, p < 0.05). The difference was observed in case of primary infertility, but not in terms of the secondary one. No significant differences were noted between leptin/BMI ratio in the proliferative phase and the secretory phase (0.716 ± 0.252 vs 0.697 ± 0.288, p= 0,7785). The results of present study do not support the relevance of leptin concentration determination as a biomarker of the endometriosis. Due to the limited number of samples in the tested group, further studies are needed to confirm its role.

Sections du résumé

Background UNASSIGNED
The aim of this study was to analyze the concentration of leptin in peritoneal fluid and plasma and to assess their role as potential biomarkers in the diagnosis of endometriosis.
Materials & methods UNASSIGNED
Leptin adjusted for BMI (leptin/BMI ratio) was measured using surface plasmon resonance imaging (SPRI) biosensors. Patients with suspected endometriosis were included in the study. Plasma was collected from 70 cases, and peritoneal fluid from 67 cases. Based on the presence of endometriosis lesions detected during laparoscopy, patients were divided into a study group and a control group (patients without endometriosis).
Results UNASSIGNED
Leptin/BMI ratio in plasma did not differ between women with endometriosis and the control group (0.7159 ± 0.259 vs 0.6992 ± 0.273, p= 0,7988). No significant differences were observed in peritoneal leptin/BMI ratio levels in patients with and without endometriosis (0.6206 ± 0.258 vs 0.6215 ± 0.264, p= 0,9896). Plasma and peritoneal leptin/BMI ratios were significantly lower in women with endometriosis - related primary infertility compared to women with endometriosis without primary infertility (0.640 ± 0.502 vs 0.878 ± 0.623, p < 0.05). The difference was observed in case of primary infertility, but not in terms of the secondary one. No significant differences were noted between leptin/BMI ratio in the proliferative phase and the secretory phase (0.716 ± 0.252 vs 0.697 ± 0.288, p= 0,7785).
Conclusion UNASSIGNED
The results of present study do not support the relevance of leptin concentration determination as a biomarker of the endometriosis. Due to the limited number of samples in the tested group, further studies are needed to confirm its role.

Identifiants

DOI: 10.3389/fendo.2024.1359182 PMID: 38567305 PMC: PMC10985179
pubmed: 38567305
doi: 10.3389/fendo.2024.1359182
pmc: PMC10985179
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

1359182

Informations de copyright

Copyright © 2024 Zyguła, Sankiewicz, Sakowicz, Dobrzyńska, Dakowicz, Mańka, Kiecka, Spaczynski, Piekarski, Banaszewska, Jakimiuk, Issat, Rokita, Młodawski, Szubert, Sieroszewski, Raba, Szczupak, Kluza, Kluza, Pierzyński, Wojtyla, Lipa, Warzecha, Wielgos, Cendrowski, Gorodkiewicz and Laudanski.

Déclaration de conflit d'intérêts

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Auteurs

Aleksandra Zyguła (A)

OVIklinika Infertility Center, Warsaw, Poland.

Anna Sankiewicz (A)

Bioanalysis Laboratory, Faculty of Chemistry, University of Bialystok, Bialystok, Poland.

Agata Sakowicz (A)

Department of Medical Biotechnology, Medical University of Lodz, Lodz, Poland.

Ewa Dobrzyńska (E)

Chair and Department of Obstetrics, Gynecology and Gynecological Oncology, Medical University of Warsaw, Warsaw, Poland.

Agnieszka Dakowicz (A)

Department of Rehabilitation, Medical University of Bialystok, Bialystok, Poland.

Grzegorz Mańka (G)

Angelius Provita Hospital, Katowice, Poland.

Mariusz Kiecka (M)

Angelius Provita Hospital, Katowice, Poland.

Robert Spaczynski (R)

Center for Gynecology, Obstetrics and Infertility Treatment Pastelova, Poznan, Poland.
Collegium Medicum, University of Zielona Gora, Zielona Gora, Poland.

Piotr Piekarski (P)

Gynecological Obstetric Clinical Hospital of Poznan University of Medical Sciences, Minimally Invasive Gynecological Surgery, Poznan, Poland.

Beata Banaszewska (B)

Chair and Department of Laboratory Diagnostics, Poznan University of Medical Sciences, Poznan, Poland.

Artur Jakimiuk (A)

Department of Reproductive Health, Institute of Mother and Child in Warsaw, Warsaw, Poland.
Department of Obstetrics and Gynecology, Central Clinical Hospital of the Ministry of Interior, Warsaw, Poland.

Tadeusz Issat (T)

Department of Obstetrics and Gynecology, Institute of Mother and Child in Warsaw, Warsaw, Poland.

Wojciech Rokita (W)

Collegium Medicum, Jan Kochanowski University in Kielce, Kielce, Poland.
Clinic of Obstetrics and Gynecology, Provincial Combined Hospital in Kielce, Kielce, Poland.

Jakub Młodawski (J)

Collegium Medicum, Jan Kochanowski University in Kielce, Kielce, Poland.
Clinic of Obstetrics and Gynecology, Provincial Combined Hospital in Kielce, Kielce, Poland.

Maria Szubert (M)

Department of Gynecology and Obstetrics, Medical University of Lodz, Lodz, Poland.
Department of Surgical Gynecology and Oncology, Medical University of Lodz, Lodz, Poland.

Piotr Sieroszewski (P)

Department of Gynecology and Obstetrics, Medical University of Lodz, Lodz, Poland.
Department of Fetal Medicine and Gynecology, Medical University of Lodz, Lodz, Poland.

Grzegorz Raba (G)

Clinic of Obstetric and Gynecology in Przemysl, Przemysl, Poland.
Medical College of Rzeszow University, Rzeszow, Poland.

Kamil Szczupak (K)

Clinic of Obstetric and Gynecology in Przemysl, Przemysl, Poland.
Medical College of Rzeszow University, Rzeszow, Poland.

Tomasz Kluza (T)

Department of Gynecology, Gynecology Oncology and Obstetrics, Institute of Medical Sciences, Medical College of Rzeszow University, Rzeszow, Poland.

Marek Kluza (M)

Department of Gynecology, Gynecology Oncology and Obstetrics, Institute of Medical Sciences, Medical College of Rzeszow University, Rzeszow, Poland.

Piotr Pierzyński (P)

OVIklinika Infertility Center, Warsaw, Poland.

Cezary Wojtyla (C)

OVIklinika Infertility Center, Warsaw, Poland.
Women's Health Research Institute, Calisia University, Kalisz, Poland.

Michal Lipa (M)

Departament of Obstetrics and Perinatology National Medical Institute of the Ministry of Interior and Administration, Warsaw, Poland.

Damian Warzecha (D)

OVIklinika Infertility Center, Warsaw, Poland.
City South Hospital, Warsaw, Warsaw, Poland.
Department of Biomedical Fundamentals of Development and Sexology, Faculty of Education, University of Warsaw, Warsaw, Poland.

Miroslaw Wielgos (M)

Departament of Obstetrics and Perinatology National Medical Institute of the Ministry of Interior and Administration, Warsaw, Poland.
Premium Medical Clinic, Warsaw, Poland.
Medical Faculty, Lazarski University, Warsaw, Poland.

Krzysztof Cendrowski (K)

Chair and Department of Obstetrics, Gynecology and Gynecological Oncology, Medical University of Warsaw, Warsaw, Poland.

Ewa Gorodkiewicz (E)

Bioanalysis Laboratory, Faculty of Chemistry, University of Bialystok, Bialystok, Poland.

Piotr Laudanski (P)

OVIklinika Infertility Center, Warsaw, Poland.
Chair and Department of Obstetrics, Gynecology and Gynecological Oncology, Medical University of Warsaw, Warsaw, Poland.
Women's Health Research Institute, Calisia University, Kalisz, Poland.

Classifications MeSH