ChatGPT vs. neurologists: a cross-sectional study investigating preference, satisfaction ratings and perceived empathy in responses among people living with multiple sclerosis.

Artificial intelligence Large language model Machine learning Multiple sclerosis

Journal

Journal of neurology
ISSN: 1432-1459
Titre abrégé: J Neurol
Pays: Germany
ID NLM: 0423161

Informations de publication

Date de publication:
03 Apr 2024
Historique:
received: 15 01 2024
accepted: 12 03 2024
revised: 11 03 2024
medline: 3 4 2024
pubmed: 3 4 2024
entrez: 3 4 2024
Statut: aheadofprint

Résumé

ChatGPT is an open-source natural language processing software that replies to users' queries. We conducted a cross-sectional study to assess people living with Multiple Sclerosis' (PwMS) preferences, satisfaction, and empathy toward two alternate responses to four frequently-asked questions, one authored by a group of neurologists, the other by ChatGPT. An online form was sent through digital communication platforms. PwMS were blind to the author of each response and were asked to express their preference for each alternate response to the four questions. The overall satisfaction was assessed using a Likert scale (1-5); the Consultation and Relational Empathy scale was employed to assess perceived empathy. We included 1133 PwMS (age, 45.26 ± 11.50 years; females, 68.49%). ChatGPT's responses showed significantly higher empathy scores (Coeff = 1.38; 95% CI = 0.65, 2.11; p > z < 0.01), when compared with neurologists' responses. No association was found between ChatGPT' responses and mean satisfaction (Coeff = 0.03; 95% CI = - 0.01, 0.07; p = 0.157). College graduate, when compared with high school education responder, had significantly lower likelihood to prefer ChatGPT response (IRR = 0.87; 95% CI = 0.79, 0.95; p < 0.01). ChatGPT-authored responses provided higher empathy than neurologists. Although AI holds potential, physicians should prepare to interact with increasingly digitized patients and guide them on responsible AI use. Future development should consider tailoring AIs' responses to individual characteristics. Within the progressive digitalization of the population, ChatGPT could emerge as a helpful support in healthcare management rather than an alternative.

Sections du résumé

BACKGROUND BACKGROUND
ChatGPT is an open-source natural language processing software that replies to users' queries. We conducted a cross-sectional study to assess people living with Multiple Sclerosis' (PwMS) preferences, satisfaction, and empathy toward two alternate responses to four frequently-asked questions, one authored by a group of neurologists, the other by ChatGPT.
METHODS METHODS
An online form was sent through digital communication platforms. PwMS were blind to the author of each response and were asked to express their preference for each alternate response to the four questions. The overall satisfaction was assessed using a Likert scale (1-5); the Consultation and Relational Empathy scale was employed to assess perceived empathy.
RESULTS RESULTS
We included 1133 PwMS (age, 45.26 ± 11.50 years; females, 68.49%). ChatGPT's responses showed significantly higher empathy scores (Coeff = 1.38; 95% CI = 0.65, 2.11; p > z < 0.01), when compared with neurologists' responses. No association was found between ChatGPT' responses and mean satisfaction (Coeff = 0.03; 95% CI = - 0.01, 0.07; p = 0.157). College graduate, when compared with high school education responder, had significantly lower likelihood to prefer ChatGPT response (IRR = 0.87; 95% CI = 0.79, 0.95; p < 0.01).
CONCLUSIONS CONCLUSIONS
ChatGPT-authored responses provided higher empathy than neurologists. Although AI holds potential, physicians should prepare to interact with increasingly digitized patients and guide them on responsible AI use. Future development should consider tailoring AIs' responses to individual characteristics. Within the progressive digitalization of the population, ChatGPT could emerge as a helpful support in healthcare management rather than an alternative.

Identifiants

pubmed: 38568227
doi: 10.1007/s00415-024-12328-x
pii: 10.1007/s00415-024-12328-x
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

© 2024. The Author(s).

Références

Jiang F, Jiang Y, Zhi H, Dong Y, Li H, Ma S, Wang Y, Dong Q, Shen H, Wang Y (2017) Artificial intelligence in healthcare: past, present and future. Stroke Vasc Neurol 2(4):230–243. https://doi.org/10.1136/svn-2017-000101
doi: 10.1136/svn-2017-000101 pubmed: 29507784 pmcid: 5829945
Ortiz M, Mallen V, Boquete L, Sánchez-Morla EM, Cordón B, Vilades E, Dongil-Moreno FJ, Miguel-Jiménez JM, Garcia-Martin E (2023) Diagnosis of multiple sclerosis using optical coherence tomography supported by artificial intelligence. Mult Scler Relat Disord 74:104725. https://doi.org/10.1016/j.msard.2023.104725
doi: 10.1016/j.msard.2023.104725 pubmed: 37086637
Afzal HMR, Luo S, Ramadan S, Lechner-Scott J (2022) The emerging role of artificial intelligence in multiple sclerosis imaging. Mult Scler 28(6):849–858. https://doi.org/10.1177/1352458520966298
doi: 10.1177/1352458520966298 pubmed: 33112207
Zivadinov R, Bergsland N, Jakimovski D, Weinstock-Guttman B, Benedict RHB, Riolo J, Silva D, Dwyer MG (2022) DeepGRAI registry study group. Thalamic atrophy measured by artificial intelligence in a multicentre clinical routine real-word study is associated with disability progression. J Neurol Neurosurg Psychiatry jnnp. https://doi.org/10.1136/jnnp-2022-329333
doi: 10.1136/jnnp-2022-329333
ChatGPT. https://openai.com/blog/chatgpt . Accessed Dec 2023
Shah NH, Entwistle D, Pfeffer MA (2023) Creation and adoption of large language models in medicine. JAMA 330(9):866–869. https://doi.org/10.1001/jama.2023.14217
doi: 10.1001/jama.2023.14217 pubmed: 37548965
ChatGPT Statistics 2023: Trends and the Future Perspectives. https://blog.gitnux.com/chat-gpt-statistics/ . Accessed Nov 2023
Goodman RS, Patrinely JR, Stone CA Jr et al (2023) Accuracy and reliability of chatbot responses to physician questions. JAMA Netw Open 6(10):e2336483. https://doi.org/10.1001/jamanetworkopen.2023.36483
doi: 10.1001/jamanetworkopen.2023.36483 pubmed: 37782499 pmcid: 10546234
Ali SR, Dobbs TD, Hutchings HA, Whitaker IS (2023) Using ChatGPT to write patient clinic letters. Lancet Digit Health 5(4):e179–e181. https://doi.org/10.1016/S2589-7500(23)00048-1
doi: 10.1016/S2589-7500(23)00048-1 pubmed: 36894409
Inojosa H, Gilbert S, Kather JN, Proschmann U, Akgün K, Ziemssen T (2023) Can ChatGPT explain it? Use of artificial intelligence in multiple sclerosis communication. Neurol Res Pract 5(1):48. https://doi.org/10.1186/s42466-023-00270-8
doi: 10.1186/s42466-023-00270-8 pubmed: 37649106 pmcid: 10469796
Madrigal L, Escoffery C (2019) Electronic health behaviors among us adults with chronic disease: cross-sectional survey. J Med Internet Res 21(3):e11240. https://doi.org/10.2196/11240
doi: 10.2196/11240 pubmed: 30835242 pmcid: 6423466
Charness N, Boot WR (2023) A grand challenge for psychology: reducing the age-related digital divide. Curr Dir Psychol Sci 31(2):187–193. https://doi.org/10.1177/09637214211068144
doi: 10.1177/09637214211068144
Vandenbroucke JP, von Elm E, Altman DG, Gøtzsche PC, Mulrow CD, Pocock SJ, Poole C, Schlesselman JJ, Egger M (2007) STROBE initiative. Strengthening the reporting of observational studies in epidemiology (STROBE): explanation and elaboration. Epidemiology 18(6):805–835. https://doi.org/10.1097/EDE.0b013e3181577511
doi: 10.1097/EDE.0b013e3181577511 pubmed: 18049195
Digital Technology, Web and Social Media Study Group. https://www.neuro.it/web/eventi/NEURO/gruppi.cfm?p=DIGITAL_WEB_SOCIAL . Accessed Dec 2023
Research Randomizer. https://www.randomizer.org . Accessed July 2023
Kroenke K, Spitzer RL, Williams JB (2003) The Patient Health Questionnaire-2: validity of a two-item depression screener. Med Care 41(11):1284–1292. https://doi.org/10.1097/01.MLR.0000093487.78664.3C
doi: 10.1097/01.MLR.0000093487.78664.3C pubmed: 14583691
Beswick E, Quigley S, Macdonald P, Patrick S, Colville S, Chandran S, Connick P (2022) The Patient Health Questionnaire (PHQ-9) as a tool to screen for depression in people with multiple sclerosis: a cross-sectional validation study. BMC Psychol 10(1):281. https://doi.org/10.1186/s40359-022-00949-8
doi: 10.1186/s40359-022-00949-8 pubmed: 36443880 pmcid: 9706934
Patten SB, Burton JM, Fiest KM, Wiebe S, Bulloch AG, Koch M, Dobson KS, Metz LM, Maxwell CJ, Jetté N (2015) Validity of four screening scales for major depression in MS. Mult Scler 21(8):1064–1071. https://doi.org/10.1177/1352458514559297
doi: 10.1177/1352458514559297 pubmed: 25583846
Mercer SW, Maxwell M, Heaney D, Watt GC (2004) The consultation and relational empathy (CARE) measure: development and preliminary validation and reliability of an empathy-based consultation process measure. Fam Pract 21(6):699–705. https://doi.org/10.1093/fampra/cmh621
doi: 10.1093/fampra/cmh621 pubmed: 15528286
Wang Y, Wang P, Wu Q, Wang Y, Lin B, Long J, Qing X, Wang P (2023) Doctors’ and patients’ perceptions of impacts of doctors’ communication and empathy skills on doctor-patient relationships during COVID-19. J Gen Intern Med 38(2):428–433. https://doi.org/10.1007/s11606-022-07784-y
doi: 10.1007/s11606-022-07784-y pubmed: 36253633
Martikainen S, Falcon M, Wikström V, Peltola S, Saarikivi K (2022) Perceptions of doctors’ empathy and patients’ subjective health status at an online clinic: development of an empathic Anamnesis Questionnaire. Psychosom Med 84(4):513–521. https://doi.org/10.1097/PSY.0000000000001055
doi: 10.1097/PSY.0000000000001055 pubmed: 35100186 pmcid: 9071034
Lucisano P, Piemontese ME (1988) Gulpease: a formula to predict readability of texts written in Italian Language. Scuola Città 3:110–124
Dell’orletta F, Montemagni S, Venturi G (2011) READ-IT: assessing readability of italian texts with a view to text simplification, in Proceedings of the Workshop on Speech and Language Processing for Assistive Technologies. Edinburgh, pp 73–83
Zhao YC, Zhao M, Song S (2022) Online health information seeking among patients with chronic conditions: integrating the health belief model and social support theory. J Med Internet Res 24(11):e42447. https://doi.org/10.2196/42447
doi: 10.2196/42447 pubmed: 36322124 pmcid: 9669891
Brigo F, Lattanzi S, Bragazzi N, Nardone R, Moccia M, Lavorgna L (2018) Why do people search wikipedia for information on multiple sclerosis? Mult Scler Relat Disord 20:210–214. https://doi.org/10.1016/j.msard.2018.02.001
doi: 10.1016/j.msard.2018.02.001 pubmed: 29428464
Ayoub NF, Lee YJ, Grimm D, Balakrishnan K (2023) Comparison between ChatGPT and google search as sources of postoperative patient instructions. JAMA Otolaryngol Head Neck Surg 149(6):556–558. https://doi.org/10.1001/jamaoto.2023.0704
doi: 10.1001/jamaoto.2023.0704 pubmed: 37103921
Lavorgna L, De Stefano M, Sparaco M, Moccia M, Abbadessa G, Montella P, Buonanno D, Esposito S, Clerico M, Cenci C, Trojsi F, Lanzillo R, Rosa L, Morra VB, Ippolito D, Maniscalco G, Bisecco A, Tedeschi G, Bonavita S (2018) Fake news, influencers and health-related professional participation on the web: a pilot study on a social-network of people with multiple sclerosis. Mult Scler Relat Disord 25:175–178. https://doi.org/10.1016/j.msard.2018.07.046
doi: 10.1016/j.msard.2018.07.046 pubmed: 30096683
Herzer KR, Pronovost PJ (2021) Ensuring quality in the era of virtual care. JAMA 325(5):429–430. https://doi.org/10.1016/j.msard.2018.07.046
doi: 10.1016/j.msard.2018.07.046 pubmed: 33528544
Mello MM, Guha N (2023) ChatGPT and physicians’ malpractice risk. JAMA Health Forum 4(5):e231938. https://doi.org/10.1001/jamahealthforum.2023.1938
doi: 10.1001/jamahealthforum.2023.1938 pubmed: 37200013
van Laar E, van Deursen AJAM, van Dijk JAGM, de Haan J (2020) Determinants of 21st-century skills and 21st-century digital skills for workers: a systematic literature review. SAGE Open. https://doi.org/10.1177/2158244019900176
doi: 10.1177/2158244019900176
National Research Council (2000) How people learn: brain, mind, experience, and school expanded edition. The National Academies Press, Washington, DC
Ayers JW, Poliak A, Dredze M, Leas EC, Zhu Z, Kelley JB, Faix DJ, Goodman AM, Longhurst CA, Hogarth M, Smith DM (2023) Comparing physician and artificial intelligence chatbot responses to patient questions posted to a public social media forum. JAMA Intern Med 183(6):589–596. https://doi.org/10.1001/jamainternmed.2023.1838
doi: 10.1001/jamainternmed.2023.1838 pubmed: 37115527
Kaya F, Aydin F, Schepman A et al (2022) The roles of personality traits, AI anxiety, and demographic factors in attitudes toward artificial intelligence. Int J Hum-Comput Int. https://doi.org/10.1080/10447318.2022.2151730
doi: 10.1080/10447318.2022.2151730
Jia X, Pang Y, Liu LS (2021) Online health information seeking behavior: a systematic review. Healthcare (Basel) 9(12):1740. https://doi.org/10.3390/healthcare9121740
doi: 10.3390/healthcare9121740 pubmed: 34946466
D’Andrea A, Grifoni P, Ferri F (2023) Online health information seeking: an italian case study for analyzing citizens’ behavior and perception. Int J Environ Res Public Health 20(2):1076. https://doi.org/10.3390/ijerph20021076
doi: 10.3390/ijerph20021076 pubmed: 36673830 pmcid: 9859265
De Meo E, Portaccio E, Giorgio A et al (2021) Identifying the distinct cognitive phenotypes in multiple sclerosis. JAMA Neurol 78(4):414–425. https://doi.org/10.1001/jamaneurol.2020.4920
doi: 10.1001/jamaneurol.2020.4920 pubmed: 33393981
Hatcher-Martin JM, Busis NA, Cohen BH, Wolf RA, Jones EC, Anderson ER, Fritz JV, Shook SJ, Bove RM (2021) American academy of neurology telehealth position statement. Neurology 97(7):334–339. https://doi.org/10.1212/WNL.0000000000012185
doi: 10.1212/WNL.0000000000012185 pubmed: 33986141 pmcid: 8377877
Haluza D, Naszay M, Stockinger A, Jungwirth D (2017) Digital natives versus digital immigrants: influence of online health information seeking on the doctor-patient relationship. Health Commun 32(11):1342–1349. https://doi.org/10.1080/10410236.2016.1220044
doi: 10.1080/10410236.2016.1220044 pubmed: 27710132
Chua V, Koh JH, Koh CHG, Tyagi S (2022) The willingness to pay for telemedicine among patients with chronic diseases: systematic review. J Med Internet Res 24(4):e33372. https://doi.org/10.2196/33372
doi: 10.2196/33372 pubmed: 35416779 pmcid: 9047785
Xie Z, Chen J, Or CK (2022) Consumers’ willingness to pay for ehealth and its influencing factors: systematic review and meta-analysis. J Med Internet Res 24(9):e25959. https://doi.org/10.2196/25959
doi: 10.2196/25959 pubmed: 36103227 pmcid: 9520394
Fan W, Yan Z (2010) Factors affecting response rates of the web survey: a systematic review. Comput Hum Behav 26:132–139. https://doi.org/10.1016/j.chb.2009.10.01
doi: 10.1016/j.chb.2009.10.01
Wu MJ, Zhao K, Fils-Aime F (2022) Response rates of online surveys in published research: a meta-analysis. Comput Hum Behav. https://doi.org/10.1016/j.chbr.2022.100206
doi: 10.1016/j.chbr.2022.100206

Auteurs

Elisabetta Maida (E)

Department of Advanced Medical and Surgical Sciences, University of Campania "Luigi Vanvitelli", Via Pansini 5, 80131, Naples, Italy.

Marcello Moccia (M)

Department of Molecular Medicine and Medical Biotechnology, Federico II University of Naples, Naples, Italy.
Multiple Sclerosis Unit, Policlinico Federico II University Hospital, Naples, Italy.

Raffaele Palladino (R)

Department of Public Health, University "Federico II" of Naples, Naples, Italy.
Department of Primary Care and Public Health, Imperial College of London, London, UK.

Giovanna Borriello (G)

Department of Human Neuroscience, Sapienza University of Rome, Rome, Italy.

Giuseppina Affinito (G)

Department of Public Health, University "Federico II" of Naples, Naples, Italy.

Marinella Clerico (M)

Dipartimento di Scienze Cliniche e Biologiche, Università Di Torino, Turin, Italy.

Anna Maria Repice (AM)

Department of Neurology 2 and Tuscan Region Multiple Sclerosis Referral Centre, Careggi University Hospital, Florence, Italy.

Alessia Di Sapio (A)

Department of Neurology and Multiple Sclerosis Regional Referral Centre, AOU San Luigi Gonzaga, Orbassano, Turin, Italy.

Rosa Iodice (R)

Department of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples Federico II, Naples, Italy.

Antonio Luca Spiezia (AL)

Multiple Sclerosis Unit, Policlinico Federico II University Hospital, Naples, Italy.

Maddalena Sparaco (M)

Department of Advanced Medical and Surgical Sciences, University of Campania "Luigi Vanvitelli", Via Pansini 5, 80131, Naples, Italy.

Giuseppina Miele (G)

Department of Advanced Medical and Surgical Sciences, University of Campania "Luigi Vanvitelli", Via Pansini 5, 80131, Naples, Italy.

Floriana Bile (F)

Department of Advanced Medical and Surgical Sciences, University of Campania "Luigi Vanvitelli", Via Pansini 5, 80131, Naples, Italy.

Cristiano Scandurra (C)

Department of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples Federico II, Naples, Italy.

Diana Ferraro (D)

Department of Neuroscience, Azienda Ospedaliero-Universitaria di Modena, Modena, Emilia-Romagna, Italy.
Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy.

Maria Laura Stromillo (ML)

Department of Medicine, Surgery and Neuroscience, University of Siena, Siena, Italy.

Renato Docimo (R)

Multiple Sclerosis Center, Department of Advanced Medical and Surgical Sciences, University of Campania "Luigi Vanvitelli", Naples, Italy.

Antonio De Martino (A)

Institute of Neurology, University Magna Graecia of Catanzaro, Catanzaro, Italy.

Luca Mancinelli (L)

Neurology Unit, Bufalini Hospital, Local Health Agency of Romagna, Cesena, Italy.

Gianmarco Abbadessa (G)

Department of Advanced Medical and Surgical Sciences, University of Campania "Luigi Vanvitelli", Via Pansini 5, 80131, Naples, Italy.
Department of Brain Sciences, Imperial College London, London, W120BZ, UK.

Krzysztof Smolik (K)

Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy.

Lorenzo Lorusso (L)

Neurology Unit-Neuroscience Department A.S.S.T.Lecco, Merate Hospital, 23807, Merate, Italy.

Maurizio Leone (M)

Neurology Unit, Fondazione IRCCS Casa Sollievo della Sofferenza, 71013, San Giovanni Rotondo, Italy.

Elisa Leveraro (E)

Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DiNOGMI), University of Genoa, Genoa, Italy.
Department of Neurology, IRCSS Ospedale Policlinico San Martino, Genoa, Italy.

Francesca Lauro (F)

Department of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples Federico II, Naples, Italy.

Francesca Trojsi (F)

Department of Advanced Medical and Surgical Sciences, University of Campania "Luigi Vanvitelli", Via Pansini 5, 80131, Naples, Italy.

Lidia Mislin Streito (LM)

Dipartimento di Scienze Cliniche e Biologiche, Università Di Torino, Turin, Italy.

Francesca Gabriele (F)

Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy.

Fabiana Marinelli (F)

Neurology Unit, Multiple Sclerosis Center, Fabrizio Spaziani Hospital, Frosinone, Italy.

Antonio Ianniello (A)

Department of Human Neuroscience, Sapienza University of Rome, Rome, Italy.

Federica De Santis (F)

Department of Neurology and Stroke Unit of Avezzano-Sulmona, ASL 1 Avezzano-Sulmona-L'Aquila, L'Aquila, Italy.

Matteo Foschi (M)

Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy.
Department of Neuroscience, Multiple Sclerosis Center, S. Maria delle Croci Hospital, AUSL Romagna, Ravenna, Italy.

Nicola De Stefano (N)

Department of Medicine, Surgery and Neuroscience, University of Siena, Siena, Italy.

Vincenzo Brescia Morra (VB)

Department of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples Federico II, Naples, Italy.

Alvino Bisecco (A)

Multiple Sclerosis Center, Department of Advanced Medical and Surgical Sciences, University of Campania "Luigi Vanvitelli", Naples, Italy.

Giancarlo Coghe (G)

Department of Medical Sciences and Public Health, Multiple Sclerosis Center, Binaghi Hospital, ASL Cagliari, University of Cagliari, Cagliari, Italy.

Eleonora Cocco (E)

Department of Medical Sciences and Public Health, Multiple Sclerosis Center, Binaghi Hospital, ASL Cagliari, University of Cagliari, Cagliari, Italy.

Michele Romoli (M)

Neurology Unit, Bufalini Hospital, Local Health Agency of Romagna, Cesena, Italy.

Francesco Corea (F)

Dipartimento di Neurologia, Ospedale di Foligno, Azienda USL Umbria 2, Terni, Italy.

Letizia Leocani (L)

Vita-Salute San Raffaele University, Milan, Italy.
Experimental Neurophysiology Unit, Institute of Experimental Neurology-INSPE, IRCCS Scientific Institute San Raffaele, Milan, Italy.

Jessica Frau (J)

Department of Medical Sciences and Public Health, Multiple Sclerosis Center, Binaghi Hospital, ASL Cagliari, University of Cagliari, Cagliari, Italy.

Simona Sacco (S)

Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy.

Matilde Inglese (M)

Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DiNOGMI), University of Genoa, Genoa, Italy.
Department of Neurology, IRCSS Ospedale Policlinico San Martino, Genoa, Italy.

Antonio Carotenuto (A)

Department of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples Federico II, Naples, Italy.

Roberta Lanzillo (R)

Department of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples Federico II, Naples, Italy.

Alessandro Padovani (A)

Unit of Neurology, Azienda Socio-Sanitaria Territoriale Spedali Civili, Brescia, Italy.
Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.

Maria Triassi (M)

Department of Public Health, University "Federico II" of Naples, Naples, Italy.

Simona Bonavita (S)

Department of Advanced Medical and Surgical Sciences, University of Campania "Luigi Vanvitelli", Via Pansini 5, 80131, Naples, Italy. simona.bonavita@unicampania.it.

Luigi Lavorgna (L)

Department of Advanced Medical and Surgical Sciences, University of Campania "Luigi Vanvitelli", Via Pansini 5, 80131, Naples, Italy.

Classifications MeSH