Posttraumatic Headache.

Journal

Continuum (Minneapolis, Minn.)

ISSN: 1538-6899

Titre abrégé: Continuum (Minneap Minn)

Pays: United States

ID NLM: 9509333

Informations de publication

Date de publication:
01 Apr 2024

Historique:

medline: 3 4 2024

pubmed: 3 4 2024

entrez: 3 4 2024

Statut: ppublish

Résumé

This article provides an overview of the epidemiology, diagnosis, clinical presentation, pathophysiology, prognosis, and treatment of posttraumatic headache attributed to mild traumatic brain injury (mTBI). The International Classification of Headache Disorders, Third Edition requires that posttraumatic headache begin within 7 days of the inciting trauma. Although posttraumatic headache characteristics and associated symptoms vary, most commonly there is substantial overlap with symptoms of migraine or tension-type headache. New insights into posttraumatic headache pathophysiology suggest roles for neuroinflammation, altered pain processing and modulation, and changes in brain structure and function. Although the majority of posttraumatic headache resolves during the acute phase, about one-third of individuals have posttraumatic headache that persists for at least several months. Additional work is needed to identify predictors and early markers of posttraumatic headache persistence, but several potential predictors have been identified such as having migraine prior to the mTBI, the total number of TBIs ever experienced, and the severity of initial symptoms following the mTBI. Few data are available regarding posttraumatic headache treatment; studies investigating different treatments and the optimal timing for initiating posttraumatic headache treatment are needed. Posttraumatic headache begins within 7 days of the causative injury. The characteristics of posttraumatic headache most commonly resemble those of migraine or tension-type headache. Posttraumatic headache persists for 3 months or longer in about one-third of individuals. Additional studies investigating posttraumatic headache treatment are needed.

Identifiants

DOI: 10.1212/CON.0000000000001410 PMID: 38568491

pubmed: 38568491

doi: 10.1212/CON.0000000000001410

pii: 00132979-202404000-00010

doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

Pagination

411-424

Informations de copyright

Références

Headache Classification Committee of the International Headache Society (IHS). The International Classification of Headache Disorders, 3rd edition. Cephalalgia Int J Headache 2018;38(1):1–211. doi:10.1177/0333102417738202

doi: 10.1177/0333102417738202

Lucas S, Hoffman JM, Bell KR, Dikmen S. A prospective study of prevalence and characterization of headache following mild traumatic brain injury. Cephalalgia Int J Headache 2014;34(2):93–102. doi:10.1177/0333102413499645

doi: 10.1177/0333102413499645

Faul M, Xu L, Wald MM, Coronado VG. Traumatic brain injury in the United States, emergency department visits, hospitalizations and deaths 2002–2006. U.S. Department of Health and Human ServicesCenters for Disease Control and Prevention; 2010:1–72. https://www.cdc.gov/traumaticbraininjury/pdf/blue_book.pdf

Taylor CA, Bell JM, Breiding MJ, Xu L. Traumatic brain injury-related emergency department visits, hospitalizations, and deaths - United States, 2007 and 2013. Morb Mortal Wkly Rep Surveill Summ Wash DC 2002 2017;66(9):1–16. doi:10.15585/mmwr.ss6609a1

doi: 10.15585/mmwr.ss6609a1

Ashina H, Dodick DW, Barber J, et al. Prevalence of and risk factors for post-traumatic headache in civilian patients after mild traumatic brain injury: a track-TBI study. Mayo Clin Proc Published online July 21, 2023:S0025-6196(23)00113–1. doi:10.1016/j.mayocp.2023.02.026

doi: 10.1016/j.mayocp.2023.02.026

Lieba-Samal D, Platzer P, Seidel S, et al. Characteristics of acute posttraumatic headache following mild head injury. Cephalalgia Int J Headache 2011;31(16):1618–1626. doi:10.1177/0333102411428954

doi: 10.1177/0333102411428954

van der Naalt J, Timmerman ME, de Koning ME, et al. Early predictors of outcome after mild traumatic brain injury (UPFRONT): an observational cohort study. Lancet Neurol 2017;16(7):532–540. doi:10.1016/S1474-4422(17)30117-5

doi: 10.1016/S1474-4422(17)30117-5

McGeary DD, Resick PA, Penzien DB, et al. Reason to doubt the ICHD-3 7-day inclusion criterion for mild TBI-related posttraumatic headache: a nested cohort study. Cephalalgia Int J Headache 2020;40(11):1155–1167. doi:10.1177/0333102420953109

doi: 10.1177/0333102420953109

Stiell IG, Wells GA, Vandemheen K, et al. The Canadian CT Head Rule for patients with minor head injury. Lancet Lond Engl 2001;357(9266):1391–1396. doi:10.1016/s0140-6736(00)04561-x

doi: 10.1016/s0140-6736(00)04561-x

Valente JH, Anderson JD, et alAmerican College of Emergency Physicians Clinical Policies Subcommittee (Writing Committee) on Mild Traumatic Brain Injury. Clinical policy: critical issues in the management of adult patients presenting to the emergency department with mild traumatic brain injury: approved by ACEP Board of Directors, February 1, 2023 clinical policy endorsed by the Emergency Nurses Association (April 5, 2023). Ann Emerg Med 2023;81(5):e63–e105. doi:10.1016/j.annemergmed.2023.01.014

doi: 10.1016/j.annemergmed.2023.01.014

Haydel MJ, Preston CA, Mills TJ, et al. Indications for computed tomography in patients with minor head injury. N Engl J Med 2000;343(2):100–105. doi:10.1056/NEJM200007133430204

doi: 10.1056/NEJM200007133430204

Mower WR, Gupta M, Rodriguez R, Hendey GW. Validation of the sensitivity of the National Emergency X-Radiography Utilization Study (NEXUS) Head computed tomographic (CT) decision instrument for selective imaging of blunt head injury patients: an observational study. PLoS Med 2017;14(7):e1002313. doi:10.1371/journal.pmed.1002313

doi: 10.1371/journal.pmed.1002313

Ashina H, Eigenbrodt AK, Seifert T, et al. Post-traumatic headache attributed to traumatic brain injury: classification, clinical characteristics, and treatment. Lancet Neurol 2021;20(6):460–469. doi:10.1016/S1474-4422(21)00094-6

doi: 10.1016/S1474-4422(21)00094-6

Ashina H, Iljazi A, Al-Khazali HM, et al. Persistent post-traumatic headache attributed to mild traumatic brain injury: deep phenotyping and treatment patterns. Cephalalgia Int J Headache 2020;40(6):554–564. doi:10.1177/0333102420909865

doi: 10.1177/0333102420909865

Finkel AG, Ivins BJ, Yerry JA, et al. Which matters more? a retrospective cohort study of headache characteristics and diagnosis type in soldiers with mtbi/concussion. Headache 2017;57(5):719–728. doi:10.1111/head.13056

doi: 10.1111/head.13056

Burish MJ. Cluster headache, SUNCT, and SUNA. Continuum (Minneap Minn) 2024;30(2, Headache):391–410.

Metti A, Schwab K, Finkel A, et al. Posttraumatic vs nontraumatic headaches: a phenotypic analysis in a military population. Neurology 2020;94(11):e1137–e1146. doi:10.1212/WNL.0000000000008935

doi: 10.1212/WNL.0000000000008935

Hanna JJ, Chong CD, Dumkrieger GM, Ross KB, Schwedt TJ. Sensory hypersensitivities in those with persistent post-traumatic headache versus migraine. Cephalalgia Rep 2020;3:2515816320942191. doi:10.1177/2515816320942191

doi: 10.1177/2515816320942191

Starling AJ, Cortez MM, Jarvis NR, et al. Cutaneous heat and light-induced pain thresholds in post-traumatic headache attributed to mild traumatic brain injury. Headache 2022;62(6):726–736. doi:10.1111/head.14318

doi: 10.1111/head.14318

Howard L, Dumkrieger G, Chong CD, et al. Symptoms of autonomic dysfunction among those with persistent posttraumatic headache attributed to mild traumatic brain injury: a comparison to migraine and healthy controls. Headache 2018;58(9):1397–1407. doi:10.1111/head.13396

doi: 10.1111/head.13396

Taylor AA, McCauley SR, Strutt AM. Postconcussional syndrome: clinical diagnosis and treatment. Neurol Clin 2023;41(1):161–176. doi:10.1016/j.ncl.2022.08.003

doi: 10.1016/j.ncl.2022.08.003

Ashina H, Porreca F, Anderson T, et al. Post-traumatic headache: epidemiology and pathophysiological insights. Nat Rev Neurol 2019;15(10):607–617. doi:10.1038/s41582-019-0243-8

doi: 10.1038/s41582-019-0243-8

Mayer CL, Huber BR, Peskind E. Traumatic brain injury, neuroinflammation, and post-traumatic headaches. Headache 2013;53(9):1523–1530. doi:10.1111/head.12173

doi: 10.1111/head.12173

Bree D, Levy D. Intact mast cell content during mild head injury is required for development of latent pain sensitization: implications for mechanisms underlying post-traumatic headache. Pain 2019;160(5):1050–1058. doi:10.1097/j.pain.0000000000001481

doi: 10.1097/j.pain.0000000000001481

Loane DJ, Byrnes KR. Role of microglia in neurotrauma. Neurother J Am Soc Exp Neurother 2010;7(4):366–377. doi:10.1016/j.nurt.2010.07.002

doi: 10.1016/j.nurt.2010.07.002

Daiutolo BV, Tyburski A, Clark SW, Elliott MB. Trigeminal pain molecules, allodynia, and photosensitivity are pharmacologically and genetically modulated in a model of traumatic brain injury. J Neurotrauma 2016;33(8):748–760. doi:10.1089/neu.2015.4087

doi: 10.1089/neu.2015.4087

Navratilova E, Rau J, Oyarzo J, et al. CGRP-dependent and independent mechanisms of acute and persistent post-traumatic headache following mild traumatic brain injury in mice. Cephalalgia Int J Headache 2019;39(14):1762–1775. doi:10.1177/0333102419877662

doi: 10.1177/0333102419877662

Ashina H, Iljazi A, Al-Khazali HM, et al. CGRP-induced migraine-like headache in persistent post-traumatic headache attributed to mild traumatic brain injury. J Headache Pain 2022;23(1):135. doi:10.1186/s10194-022-01499-5

doi: 10.1186/s10194-022-01499-5

Defrin R, Gruener H, Schreiber S, Pick CG. Quantitative somatosensory testing of subjects with chronic post-traumatic headache: implications on its mechanisms. Eur J Pain Lond Engl 2010;14(9):924–931. doi:10.1016/j.ejpain.2010.03.004

doi: 10.1016/j.ejpain.2010.03.004

Ashina H, Al-Khazali HM, Iljazi A, et al. Total tenderness score and pressure pain thresholds in persistent post-traumatic headache attributed to mild traumatic brain injury. J Headache Pain 2022;23(1):96. doi:10.1186/s10194-022-01457-1

doi: 10.1186/s10194-022-01457-1

Kopruszinski CM, Turnes JM, Swiokla J, et al. CGRP monoclonal antibody prevents the loss of diffuse noxious inhibitory controls (DNIC) in a mouse model of post-traumatic headache. Cephalalgia Int J Headache 2021;41(6):749–759. doi:10.1177/0333102420981688

doi: 10.1177/0333102420981688

Defrin R, Riabinin M, Feingold Y, Schreiber S, Pick CG. Deficient pain modulatory systems in patients with mild traumatic brain and chronic post-traumatic headache: implications for its mechanism. J Neurotrauma 2015;32(1):28–37. doi:10.1089/neu.2014.3359

doi: 10.1089/neu.2014.3359

Naugle KM, Carey C, Evans E, et al. The role of deficient pain modulatory systems in the development of persistent post-traumatic headaches following mild traumatic brain injury: an exploratory longitudinal study. J Headache Pain 2020;21(1):138. doi:10.1186/s10194-020-01207-1

doi: 10.1186/s10194-020-01207-1

Schwedt TJ. Structural and functional brain alterations in post-traumatic headache attributed to mild traumatic brain injury: a narrative review. Front Neurol 2019;10:615. doi:10.3389/fneur.2019.00615

doi: 10.3389/fneur.2019.00615

Chong CD, Berisha V, Chiang CC, Ross K, Schwedt TJ. Less cortical thickness in patients with persistent post-traumatic headache compared with healthy controls: an MRI study. Headache 2018;58(1):53–61. doi:10.1111/head.13223

doi: 10.1111/head.13223

Chong CD, Peplinski J, Berisha V, Ross K, Schwedt TJ. Differences in fibertract profiles between patients with migraine and those with persistent post-traumatic headache. Cephalalgia Int J Headache 2019;39(9):1121–1133. doi:10.1177/0333102418815650

doi: 10.1177/0333102418815650

Dumkrieger G, Chong CD, Ross K, Berisha V, Schwedt TJ. Static and dynamic functional connectivity differences between migraine and persistent post-traumatic headache: a resting-state magnetic resonance imaging study. Cephalalgia Int J Headache 2019;39(11):1366–1381. doi:10.1177/0333102419847728

doi: 10.1177/0333102419847728

Nikolova S, Schwedt TJ, Li J, et al. T2* reduction in patients with acute post-traumatic headache. Cephalalgia Int J Headache 2022;42(4-5):357–365. doi:10.1177/03331024211048509

doi: 10.1177/03331024211048509

Dumkrieger G, Chong CD, Ross K, Berisha V, Schwedt TJ. The value of brain MRI functional connectivity data in a machine learning classifier for distinguishing migraine from persistent post-traumatic headache. Front Pain Res Lausanne Switz 2022;3:1012831. doi:10.3389/fpain.2022.1012831

doi: 10.3389/fpain.2022.1012831

Chong CD, Berisha V, Ross K, et al. Distinguishing persistent post-traumatic headache from migraine: classification based on clinical symptoms and brain structural MRI data. Cephalalgia Int J Headache 2021;41(8):943–955. doi:10.1177/0333102421991819

doi: 10.1177/0333102421991819

Chong CD, Nikolova S, Dumkrieger G, et al. Thalamic subfield iron accumulation after acute mild traumatic brain injury as a marker of future post-traumatic headache intensity. Headache 2023;63(1):156–164. doi:10.1111/head.14446

doi: 10.1111/head.14446

Niu X, Bai L, Sun Y, et al. Disruption of periaqueductal grey-default mode network functional connectivity predicts persistent post-traumatic headache in mild traumatic brain injury. J Neurol Neurosurg Psychiatry 2019;90(3):326–332. doi:10.1136/jnnp-2018-318886

doi: 10.1136/jnnp-2018-318886

Obermann M, Nebel K, Schumann C, et al. Gray matter changes related to chronic posttraumatic headache. Neurology 2009;73(12):978–983. doi:10.1212/WNL.0b013e3181b8791a

doi: 10.1212/WNL.0b013e3181b8791a

Ingebrigtsen T, Waterloo K, Marup-Jensen S, Attner E, Romner B. Quantification of post-concussion symptoms 3 months after minor head injury in 100 consecutive patients. J Neurol 1998;245(9):609–612. doi:10.1007/s004150050254

doi: 10.1007/s004150050254

Voormolen DC, Haagsma JA, Polinder S, et al. Post-concussion symptoms in complicated vs. uncomplicated mild traumatic brain injury patients at three and six months post-injury: results from the CENTER-TBI study. J Clin Med 2019;8(11):1921. doi:10.3390/jcm8111921

doi: 10.3390/jcm8111921

Andersen AM, Ashina H, Iljazi A, et al. Risk factors for the development of post-traumatic headache attributed to traumatic brain injury: a systematic review. Headache 2020;60(6):1066–1075. doi:10.1111/head.13812

doi: 10.1111/head.13812

Cancelliere C, Boyle E, Côté P, et al. Development and validation of a model predicting post-traumatic headache six months after a motor vehicle collision in adults. Accid Anal Prev 2020;142:105580. doi:10.1016/j.aap.2020.105580

doi: 10.1016/j.aap.2020.105580

Mao L, Dumkrieger G, Ku D, et al. Developing multivariable models for predicting headache improvement in patients with acute post-traumatic headache attributed to mild traumatic brain injury: a preliminary study. Headache 2023;63(1):136–145. doi:10.1111/head.14450

doi: 10.1111/head.14450

Rizzoli PB. Medication-overuse headache. Continuum (Minneap Minn) 2024;30(2, Headache):379–390.

Ashina H, Iljazi A, Al-Khazali HM, et al. Efficacy, tolerability, and safety of erenumab for the preventive treatment of persistent post-traumatic headache attributed to mild traumatic brain injury: an open-label study. J Headache Pain 2020;21(1):62. doi:10.1186/s10194-020-01136-z

doi: 10.1186/s10194-020-01136-z

Erickson JC. Treatment outcomes of chronic post-traumatic headaches after mild head trauma in US soldiers: an observational study. Headache 2011;51(6):932–944. doi:10.1111/j.1526-4610.2011.01909.x

doi: 10.1111/j.1526-4610.2011.01909.x

Larsen EL, Ashina H, Iljazi A, et al. Acute and preventive pharmacological treatment of post-traumatic headache: a systematic review. J Headache Pain 2019;20(1):98. doi:10.1186/s10194-019-1051-7

doi: 10.1186/s10194-019-1051-7

Lew HL, Lin PH, Fuh JL, et al. Characteristics and treatment of headache after traumatic brain injury: a focused review. Am J Phys Med Rehabil 2006;85(7):619–627. doi:10.1097/01.phm.0000223235.09931.c0

doi: 10.1097/01.phm.0000223235.09931.c0

Zirovich MD, Pangarkar SS, Manh C, et al. Botulinum toxin type A for the treatment of post-traumatic headache: a randomized, placebo-controlled, cross-over study. Mil Med 2021;186(5-6):493–499. doi:10.1093/milmed/usaa391

doi: 10.1093/milmed/usaa391

McGeary DD, Resick PA, Penzien DB, et al. Cognitive behavioral therapy for veterans with comorbid posttraumatic headache and posttraumatic stress disorder symptoms: a randomized clinical trial. JAMA Neurol 2022;79(8):746–757. doi:10.1001/jamaneurol.2022.1567

doi: 10.1001/jamaneurol.2022.1567

Mollica A, Greben R, Oriuwa C, Siddiqi SH, Burke MJ. Neuromodulation treatments for mild traumatic brain injury and post-concussive symptoms. Curr Neurol Neurosci Rep 2022;22(3):171–181. doi:10.1007/s11910-022-01183-w

doi: 10.1007/s11910-022-01183-w