Post-translational targeting of Rab35 by the effector IcsB of Shigella determines intracellular bacterial niche formation.
CP: Microbiology
IcsB
N-fatty acylation
Rab35
Shigella
T3SS effector
post-translational modification
vacuolar rupture
Journal
Cell reports
ISSN: 2211-1247
Titre abrégé: Cell Rep
Pays: United States
ID NLM: 101573691
Informations de publication
Date de publication:
01 Apr 2024
01 Apr 2024
Historique:
received:
13
12
2022
revised:
12
11
2023
accepted:
18
03
2024
medline:
3
4
2024
pubmed:
3
4
2024
entrez:
3
4
2024
Statut:
aheadofprint
Résumé
Escape from the bacterial-containing vacuole (BCV) is a key step of Shigella host cell invasion. Rab GTPases subverted to in situ-formed macropinosomes in the vicinity of the BCV have been shown to promote its rupture. The involvement of the BCV itself has remained unclear. We demonstrate that Rab35 is non-canonically entrapped at the BCV. Stimulated emission depletion imaging localizes Rab35 directly on the BCV membranes before vacuolar rupture. The bacterial effector IcsB, a lysine N
Identifiants
pubmed: 38568808
pii: S2211-1247(24)00362-0
doi: 10.1016/j.celrep.2024.114034
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
114034Informations de copyright
Copyright © 2024. Published by Elsevier Inc.
Déclaration de conflit d'intérêts
Declaration of interests The authors declare no competing interests.