Modification of the RTX domain cap by acyl chains of adapted length rules the formation of functional hemolysin pores.

Adenylate cyclase toxin Chimera Cytotoxicity Fatty acylation RTX toxin α-Hemolysin

Journal

Biochimica et biophysica acta. Biomembranes
ISSN: 1879-2642
Titre abrégé: Biochim Biophys Acta Biomembr
Pays: Netherlands
ID NLM: 101731713

Informations de publication

Date de publication:
01 Apr 2024
Historique:
received: 01 02 2024
revised: 14 03 2024
accepted: 25 03 2024
medline: 4 4 2024
pubmed: 4 4 2024
entrez: 3 4 2024
Statut: aheadofprint

Résumé

The acylated pore-forming Repeats in ToXin (RTX) cytolysins α-hemolysin (HlyA) and adenylate cyclase toxin (CyaA) preferentially bind to β

Identifiants

pubmed: 38570122
pii: S0005-2736(24)00042-7
doi: 10.1016/j.bbamem.2024.184311
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

184311

Informations de copyright

Copyright © 2024. Published by Elsevier B.V.

Déclaration de conflit d'intérêts

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Auteurs

Anna Lepesheva (A)

Institute of Microbiology of the Czech Academy of Sciences, Prague, Czech Republic; Faculty of Science, Charles University in Prague, Prague 128 00, Czech Republic.

Michaela Grobarcikova (M)

Institute of Microbiology of the Czech Academy of Sciences, Prague, Czech Republic; Faculty of Science, Charles University in Prague, Prague 128 00, Czech Republic.

Adriana Osickova (A)

Institute of Microbiology of the Czech Academy of Sciences, Prague, Czech Republic.

David Jurnecka (D)

Institute of Microbiology of the Czech Academy of Sciences, Prague, Czech Republic.

Sarka Knoblochova (S)

Institute of Microbiology of the Czech Academy of Sciences, Prague, Czech Republic.

Monika Cizkova (M)

Institute of Microbiology of the Czech Academy of Sciences, Prague, Czech Republic.

Radim Osicka (R)

Institute of Microbiology of the Czech Academy of Sciences, Prague, Czech Republic.

Peter Sebo (P)

Institute of Microbiology of the Czech Academy of Sciences, Prague, Czech Republic. Electronic address: sebo@biomed.cas.cz.

Jiri Masin (J)

Institute of Microbiology of the Czech Academy of Sciences, Prague, Czech Republic. Electronic address: masin@biomed.cas.cz.

Classifications MeSH