Vagus nerve signal has an inhibitory influence on the development of peritoneal metastasis in murine gastric cancer.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
03 Apr 2024
03 Apr 2024
Historique:
received:
16
12
2023
accepted:
29
03
2024
medline:
4
4
2024
pubmed:
4
4
2024
entrez:
3
4
2024
Statut:
epublish
Résumé
The vagus nerve is the only pathway for transmitting parasympathetic signals between the brain and thoracoabdominal organs, thereby exhibiting anti-inflammatory functions through the cholinergic anti-inflammatory pathway. Despite often being resected during lymph node dissection in upper gastrointestinal cancer surgery, the impact of vagotomy on postoperative outcomes in gastric cancer patients remains unclear. Sub-diaphragmatic vagotomy was performed on C57BL/6 mice. Three weeks later, syngeneic murine gastric cancer cell line YTN16P was injected into the peritoneal cavity, and the number of peritoneal metastases (PM) on the mesentery and omentum compared with control mice. The phenotypes of immune cells in peritoneal lavage and omental milky spots one day after tumor inoculation were analyzed using flow cytometry and immunohistochemistry. Intraperitoneal transfer of 3 × 10
Identifiants
pubmed: 38570542
doi: 10.1038/s41598-024-58440-w
pii: 10.1038/s41598-024-58440-w
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
7832Subventions
Organisme : Japan Society for the Promotion of Science
ID : 21K08740
Organisme : Japan Society for the Promotion of Science
ID : 21K08740
Organisme : Japan Society for the Promotion of Science
ID : 21K08740
Informations de copyright
© 2024. The Author(s).
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