GSNOR negatively regulates the NLRP3 inflammasome via S-nitrosation of MAPK14.
S-nitrosation
Colitis
GSNOR
MAPK14
NLRP3 inflammasome
Septic shock
Journal
Cellular & molecular immunology
ISSN: 2042-0226
Titre abrégé: Cell Mol Immunol
Pays: China
ID NLM: 101242872
Informations de publication
Date de publication:
03 Apr 2024
03 Apr 2024
Historique:
received:
03
09
2023
accepted:
17
03
2024
medline:
4
4
2024
pubmed:
4
4
2024
entrez:
3
4
2024
Statut:
aheadofprint
Résumé
Hyperactivation of the NLRP3 inflammasome has been implicated in the pathogenesis of numerous diseases. However, the precise molecular mechanisms that modulate the transcriptional regulation of NLRP3 remain largely unknown. In this study, we demonstrated that S-nitrosoglutathione reductase (GSNOR) deficiency in macrophages leads to significant increases in the Nlrp3 and Il-1β expression levels and interleukin-1β (IL-1β) secretion in response to NLRP3 inflammasome stimulation. Furthermore, in vivo experiments utilizing Gsnor
Identifiants
pubmed: 38570588
doi: 10.1038/s41423-024-01155-9
pii: 10.1038/s41423-024-01155-9
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© 2024. The Author(s), under exclusive licence to CSI and USTC.
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