Generating prophylactic immunity against arboviruses in vertebrates and invertebrates.


Journal

Nature reviews. Immunology
ISSN: 1474-1741
Titre abrégé: Nat Rev Immunol
Pays: England
ID NLM: 101124169

Informations de publication

Date de publication:
03 Apr 2024
Historique:
accepted: 29 02 2024
medline: 4 4 2024
pubmed: 4 4 2024
entrez: 3 4 2024
Statut: aheadofprint

Résumé

The World Health Organization recently declared a global initiative to control arboviral diseases. These are mainly caused by pathogenic flaviviruses (such as dengue, yellow fever and Zika viruses) and alphaviruses (such as chikungunya and Venezuelan equine encephalitis viruses). Vaccines represent key interventions for these viruses, with licensed human and/or veterinary vaccines being available for several members of both genera. However, a hurdle for the licensing of new vaccines is the epidemic nature of many arboviruses, which presents logistical challenges for phase III efficacy trials. Furthermore, our ability to predict or measure the post-vaccination immune responses that are sufficient for subclinical outcomes post-infection is limited. Given that arboviruses are also subject to control by the immune system of their insect vectors, several approaches are now emerging that aim to augment antiviral immunity in mosquitoes, including Wolbachia infection, transgenic mosquitoes, insect-specific viruses and paratransgenesis. In this Review, we discuss recent advances, current challenges and future prospects in exploiting both vertebrate and invertebrate immune systems for the control of flaviviral and alphaviral diseases.

Identifiants

pubmed: 38570719
doi: 10.1038/s41577-024-01016-6
pii: 10.1038/s41577-024-01016-6
doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

© 2024. Springer Nature Limited.

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Auteurs

Daniel J Rawle (DJ)

QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.

Leon E Hugo (LE)

QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.

Abigail L Cox (AL)

QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.

Gregor J Devine (GJ)

QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
GVN Centre of Excellence, Australian Infectious Disease Research Centre, Brisbane, Queensland, Australia.

Andreas Suhrbier (A)

QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia. Andreas.Suhrbier@qimrberghofer.edu.au.
GVN Centre of Excellence, Australian Infectious Disease Research Centre, Brisbane, Queensland, Australia. Andreas.Suhrbier@qimrberghofer.edu.au.

Classifications MeSH