CD137

CD137+ T cells Immune checkpoint inhibitors Immunotherapy MDSCs NSCLC Pembrolizumab Soluble immune checkpoints Tregs

Journal

Journal of translational medicine
ISSN: 1479-5876
Titre abrégé: J Transl Med
Pays: England
ID NLM: 101190741

Informations de publication

Date de publication:
03 Apr 2024
Historique:
received: 05 02 2024
accepted: 28 03 2024
medline: 4 4 2024
pubmed: 4 4 2024
entrez: 3 4 2024
Statut: epublish

Résumé

Immune checkpoint inhibitors (ICIs), administered alone or combined with chemotherapy, are the standard of care in advanced non-oncogene addicted Non-Small Cell Lung Cancer (NSCLC). Despite these treatments' success, most long-term survival benefit is restricted to approximately 20% of patients, highlighting the need to identify novel biomarkers to optimize treatment strategies. In several solid tumors, immune soluble factors, the activatory CD137 The levels of T cells, MDSCs and soluble factors were evaluated in 89 metastatic NSCLC patients who underwent ICIs as first- or second-line treatment. T cell analysis was performed by cytoflurimetry evaluating Tregs and different CD137 In both groups of patients, high levels of circulating CD137 High levels of CD137

Sections du résumé

BACKGROUND BACKGROUND
Immune checkpoint inhibitors (ICIs), administered alone or combined with chemotherapy, are the standard of care in advanced non-oncogene addicted Non-Small Cell Lung Cancer (NSCLC). Despite these treatments' success, most long-term survival benefit is restricted to approximately 20% of patients, highlighting the need to identify novel biomarkers to optimize treatment strategies. In several solid tumors, immune soluble factors, the activatory CD137
METHODS METHODS
The levels of T cells, MDSCs and soluble factors were evaluated in 89 metastatic NSCLC patients who underwent ICIs as first- or second-line treatment. T cell analysis was performed by cytoflurimetry evaluating Tregs and different CD137
RESULTS RESULTS
In both groups of patients, high levels of circulating CD137
CONCLUSION CONCLUSIONS
High levels of CD137

Identifiants

pubmed: 38570798
doi: 10.1186/s12967-024-05142-6
pii: 10.1186/s12967-024-05142-6
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

329

Subventions

Organisme : Sapienza Università di Roma
ID : RM12117A7B767D0D
Organisme : Sapienza Università di Roma
ID : RP122181610A7266
Organisme : Sapienza Università di Roma
ID : RM12117A85361029
Organisme : Sapienza Università di Roma
ID : RM120172B803DB14
Organisme : Sapienza Università di Roma
ID : RM120172B40A805A
Organisme : Sapienza Università di Roma
ID : RM123188C3F3E706
Organisme : Sapienza Università di Roma
ID : RM123188C3F3E706
Organisme : Ministero dell'Università e della Ricerca
ID : 2022K5RYF5

Informations de copyright

© 2024. The Author(s).

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Auteurs

Alain Gelibter (A)

Division of Oncology, Department of Radiological, Oncological and Pathological Science, Policlinico Umberto I, "Sapienza" University of Rome, Rome, Italy.

Angela Asquino (A)

Laboratory of Tumor Immunology and Cell Therapies, Department of Experimental Medicine, Sapienza University of Rome, Viale Regina Elena 324, 00161, Rome, Italy.

Lidia Strigari (L)

Department of Medical Physics, IRCCS Azienda Ospedaliera-Universitaria Di Bologna, 40138, Bologna, Italy.

Ilaria Grazia Zizzari (IG)

Laboratory of Tumor Immunology and Cell Therapies, Department of Experimental Medicine, Sapienza University of Rome, Viale Regina Elena 324, 00161, Rome, Italy.

Lucrezia Tuosto (L)

Laboratory of Tumor Immunology and Cell Therapies, Department of Experimental Medicine, Sapienza University of Rome, Viale Regina Elena 324, 00161, Rome, Italy.

Fabio Scirocchi (F)

Laboratory of Tumor Immunology and Cell Therapies, Department of Experimental Medicine, Sapienza University of Rome, Viale Regina Elena 324, 00161, Rome, Italy.

Angelica Pace (A)

Laboratory of Tumor Immunology and Cell Therapies, Department of Experimental Medicine, Sapienza University of Rome, Viale Regina Elena 324, 00161, Rome, Italy.

Marco Siringo (M)

Division of Oncology, Department of Radiological, Oncological and Pathological Science, Policlinico Umberto I, "Sapienza" University of Rome, Rome, Italy.

Elisa Tramontano (E)

Division of Oncology, Department of Radiological, Oncological and Pathological Science, Policlinico Umberto I, "Sapienza" University of Rome, Rome, Italy.

Serena Bianchini (S)

Laboratory of Seminology-Sperm Bank "Loredana Gandini", Department of Experimental Medicine, "Sapienza" University of Rome, 00161, Rome, Italy.

Filippo Bellati (F)

Department of Medical and Surgical Sciences and Translational Medicine, Sant'Andrea University Hospital, Sapienza University of Rome, Via Di Grottarossa 1035, 00189, Rome, Italy.

Andrea Botticelli (A)

Division of Oncology, Department of Radiological, Oncological and Pathological Science, Policlinico Umberto I, "Sapienza" University of Rome, Rome, Italy.

Donatella Paoli (D)

Laboratory of Seminology-Sperm Bank "Loredana Gandini", Department of Experimental Medicine, "Sapienza" University of Rome, 00161, Rome, Italy.

Daniele Santini (D)

Division of Oncology, Department of Radiological, Oncological and Pathological Science, Policlinico Umberto I, "Sapienza" University of Rome, Rome, Italy.

Marianna Nuti (M)

Laboratory of Tumor Immunology and Cell Therapies, Department of Experimental Medicine, Sapienza University of Rome, Viale Regina Elena 324, 00161, Rome, Italy.

Aurelia Rughetti (A)

Laboratory of Tumor Immunology and Cell Therapies, Department of Experimental Medicine, Sapienza University of Rome, Viale Regina Elena 324, 00161, Rome, Italy.

Chiara Napoletano (C)

Laboratory of Tumor Immunology and Cell Therapies, Department of Experimental Medicine, Sapienza University of Rome, Viale Regina Elena 324, 00161, Rome, Italy. chiara.napoletano@uniroma1.it.

Classifications MeSH