Phenotypic and genetic effect of carotid intima-media thickness on the risk of stroke.
Carotid intima-media thickness
Genetic correlation
Mendelian randomization
Phenotypic association
Stroke
Journal
Human genetics
ISSN: 1432-1203
Titre abrégé: Hum Genet
Pays: Germany
ID NLM: 7613873
Informations de publication
Date de publication:
05 Apr 2024
05 Apr 2024
Historique:
received:
16
10
2023
accepted:
05
03
2024
medline:
5
4
2024
pubmed:
5
4
2024
entrez:
5
4
2024
Statut:
aheadofprint
Résumé
While carotid intima-media thickness (cIMT) as a noninvasive surrogate measure of atherosclerosis is widely considered a risk factor for stroke, the intrinsic link underlying cIMT and stroke has not been fully understood. We aimed to evaluate the clinical value of cIMT in stroke through the investigation of phenotypic and genetic relationships between cIMT and stroke. We evaluated phenotypic associations using observational data from UK Biobank (N = 21,526). We then investigated genetic relationships leveraging genomic data conducted in predominantly European ancestry for cIMT (N = 45,185) and any stroke (AS, N
Identifiants
pubmed: 38578439
doi: 10.1007/s00439-024-02666-1
pii: 10.1007/s00439-024-02666-1
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : National Key R&D Program of China
ID : 2022YFC3600600, 2022YFC3600604
Organisme : National Natural Science Foundation of China
ID : U22A20359, 81874283, 81673255
Organisme : Recruitment Program for Young Professionals of China
ID : N/A
Organisme : Promotion Plan for Basic Medical Sciences and the Development Plan for Cutting-Edge Disciplines, Sichuan University
ID : N/A
Organisme : Projects from West China School of Public Health and West China Fourth Hospital, Sichuan University
ID : N/A
Informations de copyright
© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
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