Older adults with reduced cerebrovascular reactivity exhibit high white matter hyperintensity burden.

Cerebrovascular reactivity Small Vessel disease White matter hyperintensities

Journal

Neurobiology of aging
ISSN: 1558-1497
Titre abrégé: Neurobiol Aging
Pays: United States
ID NLM: 8100437

Informations de publication

Date de publication:
30 Mar 2024
Historique:
received: 12 12 2023
revised: 17 03 2024
accepted: 22 03 2024
medline: 6 4 2024
pubmed: 6 4 2024
entrez: 5 4 2024
Statut: aheadofprint

Résumé

Cerebrovascular reactivity (CVR) deficits may contribute to small vessel disease, such as white matter hyperintensities (WMH). Moreover, apolipoprotein-e4 (APOE4) carriers at genetic risk for Alzheimer's disease exhibit cerebrovascular dysfunction relative to non-carriers. We examined whether older adults, and APOE4 carriers specifically, with diminished CVR would exhibit higher WMH burden. Independently living older adults (N = 125, mean age = 69.2 years; SD = 7.6; 31.2% male) free of dementia or clinical stroke underwent brain MRI to quantify cerebral perfusion during CVR to hypercapnia and hypocapnia and determine WMH volume. Adjusting for age, sex and intracranial volume, hierarchical regression analysis revealed a significant association between whole brain CVR to hypercapnia and WMH overall [B = -.02, 95% CI (-.04, -.008), p =.003] and in APOE4 carriers [B = -.03, 95% CI (-.06, -.009), p =.009]. Findings suggest deficits in cerebral vasodilatory capacity are associated with WMH burden in older adults and future studies are warranted to further delineate the effect of APOE4 on precipitating WMH.

Identifiants

DOI: 10.1016/j.neurobiolaging.2024.03.006 PMID: 38579393
pubmed: 38579393
pii: S0197-4580(24)00064-2
doi: 10.1016/j.neurobiolaging.2024.03.006
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

5-10

Informations de copyright

Copyright © 2024 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Competing Interest None.

Auteurs

Arunima Kapoor (A)

Department of Psychological Science, University of California, Irvine, Irvine, CA, USA.

Shubir Dutt (S)

Department of Psychology, University of Southern California, Los Angeles, CA, USA.

John Paul M Alitin (JPM)

Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, CA, USA.

Isabel J Sible (IJ)

Department of Psychology, University of Southern California, Los Angeles, CA, USA.

Anisa Marshall (A)

Department of Psychology, University of Southern California, Los Angeles, CA, USA.

Fatemah Shenasa (F)

Department of Psychological Science, University of California, Irvine, Irvine, CA, USA.

Allison C Engstrom (AC)

Department of Psychological Science, University of California, Irvine, Irvine, CA, USA.

Aimée Gaubert (A)

Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, CA, USA.

Xingfeng Shao (X)

Stevens Neuroimaging and Informatics Institute, University of Southern California, Los Angeles, CA, USA.

David Robert Bradford (DR)

Center for Innovations in Brain Science, Department of Pharmacology, University of Arizona, Tucson, AZ, USA.

Kathleen Rodgers (K)

Center for Innovations in Brain Science, Department of Pharmacology, University of Arizona, Tucson, AZ, USA.

Mara Mather (M)

University of Southern California Leonard Davis School of Gerontology, USA.

Danny J J Wang (DJJ)

Stevens Neuroimaging and Informatics Institute, University of Southern California, Los Angeles, CA, USA.

Daniel A Nation (DA)

University of Southern California Leonard Davis School of Gerontology, USA; Department of Physiology and Neuroscience, Zilkha Neurogenetic Institute, University of Southern California Keck School of Medicine, USA. Electronic address: danation@usc.edu.

Classifications MeSH