Reporting bone marrow biopsies for myelodysplastic neoplasms and acute myeloid leukaemia incorporating WHO 5th edition and ICC 2022 classification systems: ALLG/RCPA joint committee consensus recommendations.

International Consensus Conference Myelodysplasia World Health Organization acute myeloid leukaemia

Journal

Pathology
ISSN: 1465-3931
Titre abrégé: Pathology
Pays: England
ID NLM: 0175411

Informations de publication

Date de publication:
19 Mar 2024
Historique:
received: 21 10 2023
revised: 28 01 2024
accepted: 12 02 2024
medline: 6 4 2024
pubmed: 6 4 2024
entrez: 5 4 2024
Statut: aheadofprint

Résumé

The classification of myeloid neoplasms continues to evolve along with advances in molecular diagnosis, risk stratification and treatment of disease. An approach for disease classification has been grounded in international consensus that has facilitated understanding, identification and management of molecularly heterogeneous entities, as well as enabled consistent patient stratification into clinical trials and clinical registries over time. The new World Health Organization (WHO) and International Consensus Classification (ICC) Clinical Advisory Committee releasing separate classification systems for myeloid neoplasms in 2022 precipitated some concern amongst haematopathology colleagues both locally and internationally. While both classifications emphasise molecular disease classification over the historical use of morphology, flow cytometry and cytogenetic based diagnostic methods, notable differences exist in how morphological, molecular and cytogenetic criteria are applied for defining myelodysplastic neoplasms (MDS) and acute myeloid leukaemias (AML). Here we review the conceptual advances, diagnostic nuances, and molecular platforms required for the diagnosis of MDS and AML using the new WHO and ICC 2022 classifications. We provide consensus recommendations for reporting bone marrow biopsies. Additionally, we address the logistical challenges encountered implementing these changes into routine laboratory practice in alignment with the National Pathology Accreditation Advisory Council reporting requirements for Australia and New Zealand.

Identifiants

DOI: 10.1016/j.pathol.2024.02.002 PMID: 38580613
pubmed: 38580613
pii: S0031-3025(24)00086-2
doi: 10.1016/j.pathol.2024.02.002
pii:
doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

Copyright © 2024 Royal College of Pathologists of Australasia. Published by Elsevier B.V. All rights reserved.

Auteurs

Ashley P Ng (AP)

Clinical Haematology Department, The Royal Melbourne Hospital and Peter MacCallum Cancer Centre, Parkville, Vic, Australia; The Walter and Eliza Hall Institute of Medical Research, Parkville, Vic, Australia; Department of Biology, University of Melbourne, Parkville, Vic, Australia; Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Vic, Australia; The Royal College of Pathologists of Australasia, Sydney, NSW, Australia. Electronic address: ashley.ng@mh.org.au.

Rebecca Adams (R)

The Royal College of Pathologists of Australasia, Sydney, NSW, Australia; The Haematology Advisory Committee, Royal College of Pathologists of Australasia, Sydney, NSW, Australia; Sullivan Nicolaides Pathology, Brisbane, Qld, Australia; The University of Queensland, Brisbane, Qld, Australia.

Ing Soo Tiong (IS)

The Royal College of Pathologists of Australasia, Sydney, NSW, Australia; Department of Pathology, Peter MacCallum Cancer Centre, Parkville, Vic, Australia; The Alfred Hospital, Melbourne, Vic, Australia; Monash University, Melbourne, Vic, Australia.

Louise Seymour (L)

The Royal College of Pathologists of Australasia, Sydney, NSW, Australia; The University of Queensland, Brisbane, Qld, Australia; Pathology Queensland, Brisbane, Qld, Australia.

Dipti Talaulikar (D)

The Royal College of Pathologists of Australasia, Sydney, NSW, Australia; The Haematology Advisory Committee, Royal College of Pathologists of Australasia, Sydney, NSW, Australia; Department of Haematology, Canberra Health Services, Canberra, ACT, Australia; College of Health and Medicine, Australian National University, Canberra, ACT, Australia.

Emma Palfreyman (E)

The Royal College of Pathologists of Australasia, Sydney, NSW, Australia; The Haematology Advisory Committee, Royal College of Pathologists of Australasia, Sydney, NSW, Australia; Department of Haematology, Royal Darwin Hospital, Tiwi, NT, Australia.

Anoop Enjeti (A)

The Royal College of Pathologists of Australasia, Sydney, NSW, Australia; The Haematology Advisory Committee, Royal College of Pathologists of Australasia, Sydney, NSW, Australia; Department of Haematology, Calvary Mater Newcastle Hospital, Waratah, NSW, Australia; NSW Health Pathology, John Hunter Hospital, New Lambton Heights, NSW, Australia; Precision Medicine Program, Hunter Medical Research Institute and University of Newcastle, Newcastle, NSW, Australia.

Courtney Tate (C)

The Royal College of Pathologists of Australasia, Sydney, NSW, Australia; The Haematology Advisory Committee, Royal College of Pathologists of Australasia, Sydney, NSW, Australia; The University of Queensland, Brisbane, Qld, Australia; Pathology Queensland, Brisbane, Qld, Australia; Princess Alexandra Hospital, Brisbane, Qld, Australia.

Classifications MeSH