The role of vasculature and angiogenesis in respiratory diseases.
COPD
COVID-19
ECFC
Endothelial mesenchymal transition (EndoMT)
Fibrovascular interface
Intussusceptive angiogenesis
Pulmonary fibrosis
Respiratory diseases
Tumor angiogenesis
Vascular normalization
Journal
Angiogenesis
ISSN: 1573-7209
Titre abrégé: Angiogenesis
Pays: Germany
ID NLM: 9814575
Informations de publication
Date de publication:
05 Apr 2024
05 Apr 2024
Historique:
received:
20
12
2023
accepted:
11
02
2024
medline:
6
4
2024
pubmed:
6
4
2024
entrez:
5
4
2024
Statut:
aheadofprint
Résumé
In European countries, nearly 10% of all hospital admissions are related to respiratory diseases, mainly chronic life-threatening diseases such as COPD, pulmonary hypertension, IPF or lung cancer. The contribution of blood vessels and angiogenesis to lung regeneration, remodeling and disease progression has been increasingly appreciated. The vascular supply of the lung shows the peculiarity of dual perfusion of the pulmonary circulation (vasa publica), which maintains a functional blood-gas barrier, and the bronchial circulation (vasa privata), which reveals a profiled capacity for angiogenesis (namely intussusceptive and sprouting angiogenesis) and alveolar-vascular remodeling by the recruitment of endothelial precursor cells. The aim of this review is to outline the importance of vascular remodeling and angiogenesis in a variety of non-neoplastic and neoplastic acute and chronic respiratory diseases such as lung infection, COPD, lung fibrosis, pulmonary hypertension and lung cancer.
Identifiants
pubmed: 38580869
doi: 10.1007/s10456-024-09910-2
pii: 10.1007/s10456-024-09910-2
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIH HHS
ID : HL94567
Pays : United States
Organisme : NIH HHS
ID : HL94567
Pays : United States
Informations de copyright
© 2024. The Author(s).
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