Bi-directional neuro-immune dysfunction after chronic experimental brain injury.
Bone marrow transplantation
Cellular senescence
Hematopoiesis
Innate immunity
Long-term reconstitution
Neuroinflammation
Neurological function
Traumatic brain injury
Journal
Journal of neuroinflammation
ISSN: 1742-2094
Titre abrégé: J Neuroinflammation
Pays: England
ID NLM: 101222974
Informations de publication
Date de publication:
05 Apr 2024
05 Apr 2024
Historique:
received:
15
01
2024
accepted:
30
03
2024
medline:
6
4
2024
pubmed:
6
4
2024
entrez:
5
4
2024
Statut:
epublish
Résumé
It is well established that traumatic brain injury (TBI) causes acute and chronic alterations in systemic immune function and that systemic immune changes contribute to posttraumatic neuroinflammation and neurodegeneration. However, how TBI affects bone marrow (BM) hematopoietic stem/progenitor cells chronically and to what extent such changes may negatively impact innate immunity and neurological function has not been examined. To further understand the role of BM cell derivatives on TBI outcome, we generated BM chimeric mice by transplanting BM from chronically injured or sham (i.e., 90 days post-surgery) congenic donor mice into otherwise healthy, age-matched, irradiated CD45.2 C57BL/6 (WT) hosts. Immune changes were evaluated by flow cytometry, multiplex ELISA, and NanoString technology. Moderate-to-severe TBI was induced by controlled cortical impact injury and neurological function was measured using a battery of behavioral tests. TBI induced chronic alterations in the transcriptome of BM lineage TBI causes chronic activation and progressive dysfunction of the BM stem/progenitor cell pool, which drives long-term deficits in hematopoiesis, innate immunity, and neurological function, as well as altered sensitivity to subsequent brain injury.
Sections du résumé
BACKGROUND
BACKGROUND
It is well established that traumatic brain injury (TBI) causes acute and chronic alterations in systemic immune function and that systemic immune changes contribute to posttraumatic neuroinflammation and neurodegeneration. However, how TBI affects bone marrow (BM) hematopoietic stem/progenitor cells chronically and to what extent such changes may negatively impact innate immunity and neurological function has not been examined.
METHODS
METHODS
To further understand the role of BM cell derivatives on TBI outcome, we generated BM chimeric mice by transplanting BM from chronically injured or sham (i.e., 90 days post-surgery) congenic donor mice into otherwise healthy, age-matched, irradiated CD45.2 C57BL/6 (WT) hosts. Immune changes were evaluated by flow cytometry, multiplex ELISA, and NanoString technology. Moderate-to-severe TBI was induced by controlled cortical impact injury and neurological function was measured using a battery of behavioral tests.
RESULTS
RESULTS
TBI induced chronic alterations in the transcriptome of BM lineage
CONCLUSIONS
CONCLUSIONS
TBI causes chronic activation and progressive dysfunction of the BM stem/progenitor cell pool, which drives long-term deficits in hematopoiesis, innate immunity, and neurological function, as well as altered sensitivity to subsequent brain injury.
Identifiants
pubmed: 38581043
doi: 10.1186/s12974-024-03082-y
pii: 10.1186/s12974-024-03082-y
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
83Subventions
Organisme : NINDS NIH HHS
ID : F32NS105355
Pays : United States
Organisme : NINDS NIH HHS
ID : R01NS110756
Pays : United States
Organisme : NINDS NIH HHS
ID : R01NS110635
Pays : United States
Organisme : NIA NIH HHS
ID : R01AG077541
Pays : United States
Informations de copyright
© 2024. The Author(s).
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