Stress-induced phosphoprotein 1: how does this co-chaperone influence the metastasis steps?
Angiogenesis
Cell-adhesion
Co-chaperone
Epithelial-to-mesenchymal transition
Stress-induced phosphoprotein 1
Journal
Clinical & experimental metastasis
ISSN: 1573-7276
Titre abrégé: Clin Exp Metastasis
Pays: Netherlands
ID NLM: 8409970
Informations de publication
Date de publication:
06 Apr 2024
06 Apr 2024
Historique:
received:
25
01
2024
accepted:
27
02
2024
medline:
6
4
2024
pubmed:
6
4
2024
entrez:
6
4
2024
Statut:
aheadofprint
Résumé
In several cancer types, metastasis is associated with poor prognosis, survival, and quality of life, representing a life risk more significant than the primary tumor itself. Metastasis is a multi-step process that spreads tumor cells from primary sites to surrounding or distant organs, originating secondary tumors. The interconnected steps that drive metastasis depend of several capabilities that enable cells to detach from the primary tumor, acquire motility and migrate through the basal membrane; invade and spread through the vascular system, and finally settle and originate a new tumor. Recently, stress-induced phosphoprotein 1 (STIP1) has emerged as a protein capable of driving tumor cells through these metastasis steps by mediating several biological processes and signaling pathways. This protein is mainly known for its function as a co-chaperone, acting as a scaffold for the interaction of its client heat-shock proteins Hsp70/90 chaperones; however, it is also known that STIP1 can act independently of chaperones to activate downstream phosphorylation pathways. The over-expression of STIP1 has been reported across various cancer types, identifying it as a potential biomarker for predicting patient prognosis and monitoring the progression of metastasis. Here, we present a discussion on how this co-chaperone mediates the initial steps of metastasis (cell adhesion loss, epithelial-to-mesenchymal transition, and angiogenesis), highlighting the biological mechanisms in which STIP1 plays a vital role, also presenting an overview of the current knowledge regarding its clinical relevance.
Identifiants
pubmed: 38581620
doi: 10.1007/s10585-024-10282-6
pii: 10.1007/s10585-024-10282-6
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
ID : 408730/2018-8
Organisme : Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
ID : 408730/2018-8
Organisme : Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
ID : 408730/2018-8
Informations de copyright
© 2024. The Author(s), under exclusive licence to Springer Nature B.V.
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