Reduced OxyR positively regulates the prodigiosin biosynthesis in Serratia marcescens FS14.

DNA binding site OxyR Prodigiosin Serratia marcescens

Journal

Biochemical and biophysical research communications
ISSN: 1090-2104
Titre abrégé: Biochem Biophys Res Commun
Pays: United States
ID NLM: 0372516

Informations de publication

Date de publication:
02 Apr 2024
Historique:
received: 05 03 2024
accepted: 31 03 2024
medline: 7 4 2024
pubmed: 7 4 2024
entrez: 6 4 2024
Statut: aheadofprint

Résumé

OxyR, a LysR family transcriptional regulator, plays vital roles in bacterial oxidative stress response. In this study, we found that the deletion of oxyR not only inhibited the antioxidant capacity of S. marcescens FS14, but also decreased the production of prodigiosin. Further study revealed that OxyR activated the prodigiosin biosynthesis at the transcriptional level. Complementary results showed that not only the wild-type OxyR but also the reduced form OxyR

Identifiants

DOI: 10.1016/j.bbrc.2024.149877 PMID: 38581956
pubmed: 38581956
pii: S0006-291X(24)00413-3
doi: 10.1016/j.bbrc.2024.149877
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

149877

Informations de copyright

Copyright © 2024 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Auteurs

Hong Liu (H)

Laboratory of Microbiological Engineering of Agricultural Environment of Ministry of Agriculture, Department of Microbiology, College of Life Sciences, Nanjing Agricultural University, Nanjing, China.

Fenglian Chu (F)

Laboratory of Microbiological Engineering of Agricultural Environment of Ministry of Agriculture, Department of Microbiology, College of Life Sciences, Nanjing Agricultural University, Nanjing, China.

Yi Wu (Y)

Laboratory of Microbiological Engineering of Agricultural Environment of Ministry of Agriculture, Department of Microbiology, College of Life Sciences, Nanjing Agricultural University, Nanjing, China.

Xiaochen Gu (X)

Laboratory of Microbiological Engineering of Agricultural Environment of Ministry of Agriculture, Department of Microbiology, College of Life Sciences, Nanjing Agricultural University, Nanjing, China.

Tingting Ran (T)

Laboratory of Microbiological Engineering of Agricultural Environment of Ministry of Agriculture, Department of Microbiology, College of Life Sciences, Nanjing Agricultural University, Nanjing, China.

Weiwu Wang (W)

Laboratory of Microbiological Engineering of Agricultural Environment of Ministry of Agriculture, Department of Microbiology, College of Life Sciences, Nanjing Agricultural University, Nanjing, China. Electronic address: wwwang@njau.edu.cn.

Dongqing Xu (D)

Laboratory of Microbiological Engineering of Agricultural Environment of Ministry of Agriculture, Department of Microbiology, College of Life Sciences, Nanjing Agricultural University, Nanjing, China. Electronic address: dqxu@njau.edu.cn.

Classifications MeSH