Remediation of Metal Oxide Nanotoxicity with a Functional Amyloid.
functional amyloid
ion release
metal oxide nanoparticle
sequestration
toxicity
Journal
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
ISSN: 2198-3844
Titre abrégé: Adv Sci (Weinh)
Pays: Germany
ID NLM: 101664569
Informations de publication
Date de publication:
06 Apr 2024
06 Apr 2024
Historique:
revised:
21
03
2024
received:
29
12
2023
medline:
7
4
2024
pubmed:
7
4
2024
entrez:
6
4
2024
Statut:
aheadofprint
Résumé
Understanding the environmental health and safety of nanomaterials (NanoEHS) is essential for the sustained development of nanotechnology. Although extensive research over the past two decades has elucidated the phenomena, mechanisms, and implications of nanomaterials in cellular and organismal models, the active remediation of the adverse biological and environmental effects of nanomaterials remains largely unexplored. Inspired by recent developments in functional amyloids for biomedical and environmental engineering, this work shows their new utility as metallothionein mimics in the strategically important area of NanoEHS. Specifically, metal ions released from CuO and ZnO nanoparticles are sequestered through cysteine coordination and electrostatic interactions with beta-lactoglobulin (bLg) amyloid, as revealed by inductively coupled plasma mass spectrometry and molecular dynamics simulations. The toxicity of the metal oxide nanoparticles is subsequently mitigated by functional amyloids, as validated by cell viability and apoptosis assays in vitro and murine survival and biomarker assays in vivo. As bLg amyloid fibrils can be readily produced from whey in large quantities at a low cost, the study offers a crucial strategy for remediating the biological and environmental footprints of transition metal oxide nanomaterials.
Identifiants
pubmed: 38582521
doi: 10.1002/advs.202310314
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2310314Subventions
Organisme : National Natural Science Foundation of China
ID : T2250710182
Organisme : National Natural Science Foundation of China
ID : 22306145
Organisme : Eesti Teadusagentuur
ID : PRG2188
Organisme : Fundamental Research Funds for the Central Universities
Organisme : Key Technologies Research and Development Program
ID : 2022YFC2409700
Organisme : Key Technologies Research and Development Program
ID : 2021YFA12009000
Informations de copyright
© 2024 The Authors. Advanced Science published by Wiley‐VCH GmbH.
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