Exploring alveolar recruitability using positive end-expiratory pressure in mice overexpressing TGF-β1: a structure-function analysis.

Acute respiratory distress syndrome Atelectasis Recruitment Stereology TGF-β1 Ventilation induced lung injury

Journal

Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288

Informations de publication

Date de publication:
06 Apr 2024
Historique:
received: 11 12 2023
accepted: 26 03 2024
medline: 7 4 2024
pubmed: 7 4 2024
entrez: 6 4 2024
Statut: epublish

Résumé

Pre-injured lungs are prone to injury progression in response to mechanical ventilation. Heterogeneous ventilation due to (micro)atelectases imparts injurious strains on open alveoli (known as volutrauma). Hence, recruitment of (micro)atelectases by positive end-expiratory pressure (PEEP) is necessary to interrupt this vicious circle of injury but needs to be balanced against acinar overdistension. In this study, the lung-protective potential of alveolar recruitment was investigated and balanced against overdistension in pre-injured lungs. Mice, treated with empty vector (AdCl) or adenoviral active TGF-β1 (AdTGF-β1) were subjected to lung mechanical measurements during descending PEEP ventilation from 12 to 0 cmH

Identifiants

DOI: 10.1038/s41598-024-58213-5 PMID: 38582767
pubmed: 38582767
doi: 10.1038/s41598-024-58213-5
pii: 10.1038/s41598-024-58213-5
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

8080

Subventions

Organisme : Deutsche Forschungsgemeinschaft
ID : 471334884
Organisme : Bundesministerium für Bildung und Forschung
ID : German Center for Lung Research

Informations de copyright

© 2024. Crown.

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Auteurs

Franziska Roeder (F)

Institute of Functional and Applied Anatomy, Hannover Medical School, Hannover, Germany.

Tina Röpke (T)

Department of Experimental Pneumology, Hannover Medical School, Hannover, Germany.

Lara-Kristin Steinmetz (LK)

Department of Experimental Pneumology, Hannover Medical School, Hannover, Germany.

Martin Kolb (M)

Department of Medicine, Firestone Institute for Respiratory Health, McMaster University, Hamilton, ON, Canada.

Ulrich A Maus (UA)

Department of Experimental Pneumology, Hannover Medical School, Hannover, Germany.
Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center for Lung Disease (DZL), Hannover, Germany.

Bradford J Smith (BJ)

Department of Bioengineering, College of Engineering Design and Computing, University of Colorado Denver|Anschutz Medical Campus, Aurora, CO, USA.
Department of Pediatric Pulmonary and Sleep Medicine, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.

Lars Knudsen (L)

Institute of Functional and Applied Anatomy, Hannover Medical School, Hannover, Germany. Knudsen.lars@mh-hannover.de.
Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center for Lung Disease (DZL), Hannover, Germany. Knudsen.lars@mh-hannover.de.

Classifications MeSH