Extracellular DNA traps in a ctenophore demonstrate immune cell behaviors in a non-bilaterian.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
06 Apr 2024
06 Apr 2024
Historique:
received:
11
04
2022
accepted:
08
03
2024
medline:
7
4
2024
pubmed:
7
4
2024
entrez:
6
4
2024
Statut:
epublish
Résumé
The formation of extracellular DNA traps (ETosis) is a first response mechanism by specific immune cells following exposure to microbes. Initially characterized in vertebrate neutrophils, cells capable of ETosis have been discovered recently in diverse non-vertebrate taxa. To assess the conservation of ETosis between evolutionarily distant non-vertebrate phyla, we observed and quantified ETosis using the model ctenophore Mnemiopsis leidyi and the oyster Crassostrea gigas. Here we report that ctenophores - thought to have diverged very early from the metazoan stem lineage - possess immune-like cells capable of phagocytosis and ETosis. We demonstrate that both Mnemiopsis and Crassostrea immune cells undergo ETosis after exposure to diverse microbes and chemical agents that stimulate ion flux. We thus propose that ETosis is an evolutionarily conserved metazoan defense against pathogens.
Identifiants
pubmed: 38582801
doi: 10.1038/s41467-024-46807-6
pii: 10.1038/s41467-024-46807-6
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2990Subventions
Organisme : National Science Foundation (NSF)
ID : 2013692
Organisme : National Science Foundation (NSF)
ID : 2013692
Organisme : National Science Foundation (NSF)
ID : 2013692
Informations de copyright
© 2024. The Author(s).
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