An EEG Signature of MCH Neuron Activities Predicts Cocaine Seeking.
Journal
bioRxiv : the preprint server for biology
Titre abrégé: bioRxiv
Pays: United States
ID NLM: 101680187
Informations de publication
Date de publication:
29 Mar 2024
29 Mar 2024
Historique:
medline:
8
4
2024
pubmed:
8
4
2024
entrez:
8
4
2024
Statut:
epublish
Résumé
Identifying biomarkers that predict substance use disorder (SUD) propensity may better strategize anti-addiction treatment. The melanin-concentrating hormone (MCH) neurons in the lateral hypothalamus (LH) critically mediates interactions between sleep and substance use; however, their activities are largely obscured in surface electroencephalogram (EEG) measures, hindering the development of biomarkers. Surface EEG signals and real-time Ca An EEG waveform derivative - a modified theta-to-delta ratio (EEG Ratio) - accurately tracks real-time Ca The identified EEG Ratio may serve as a non-invasive measure for assessing MCH neuron activities
Sections du résumé
Background
UNASSIGNED
Identifying biomarkers that predict substance use disorder (SUD) propensity may better strategize anti-addiction treatment. The melanin-concentrating hormone (MCH) neurons in the lateral hypothalamus (LH) critically mediates interactions between sleep and substance use; however, their activities are largely obscured in surface electroencephalogram (EEG) measures, hindering the development of biomarkers.
Methods
UNASSIGNED
Surface EEG signals and real-time Ca
Results
UNASSIGNED
An EEG waveform derivative - a modified theta-to-delta ratio (EEG Ratio) - accurately tracks real-time Ca
Conclusions
UNASSIGNED
The identified EEG Ratio may serve as a non-invasive measure for assessing MCH neuron activities
Identifiants
pubmed: 38586019
doi: 10.1101/2024.03.27.586887
pmc: PMC10996698
pii:
doi:
Types de publication
Preprint
Langues
eng