Urethral cancer: a comprehensive review endorsed by the Global Society of Rare Genitourinary Tumours.
multidisciplinary care
multimodal therapy
review
urethral cancer
urethral neoplasms
Journal
BJU international
ISSN: 1464-410X
Titre abrégé: BJU Int
Pays: England
ID NLM: 100886721
Informations de publication
Date de publication:
08 Apr 2024
08 Apr 2024
Historique:
medline:
8
4
2024
pubmed:
8
4
2024
entrez:
8
4
2024
Statut:
aheadofprint
Résumé
To determine the effectiveness and adverse effects of urethrectomy alone or as part of multimodal therapy (MMT). A comprehensive search was conducted across MEDLINE (OVID), EMBASE, LILACS and the Cochrane Central Register of Controlled Trials (CENTRAL) databases, from their inception to the present date. The study cohort comprised individuals aged 16 years and older diagnosed with urethral tumours at any stage who underwent either isolated urethrectomy or urethrectomy as an integral component of MMT. Ninety-two studies comprising 25 480 patients met the inclusion criteria. Surgical outcomes for urethral cancer vary considerably, with 5-year overall survival (OS) ranging from 10% to 68% based on disease extent, approach, and gender. Radiotherapy (RT) alone provides 5-year OS of approximately 40%. Combined regimens provide better outcomes compared to single modalities, including reduced recurrence and enhanced survival. However, trimodal therapy showed survival benefits only for urothelial subtypes, indicating the need to tailor management according to cancer type. MMT with neoadjuvant chemotherapy prior to surgery demonstrated the most consistent survival gains. The management of urethral cancer demands a nuanced, personalised approach, accounting for factors such as tumour location, sex, and tumour stage. MMT combining surgery, chemotherapy and RT has shown the ability to enhance outcomes in advanced disease. More extensive collaborative studies through specialised centres are imperative to advance evidence-based protocols and refine treatment in order to improve survival.
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© 2024 BJU International.
Références
Eng TY, Chen TW, Patel AJ, Vincent JN, Ha CS. Treatment and outcomes of primary urethra cancer. Am J Clin Oncol Cancer Clin Trials 2018; 41: 905–908
Mano R, Vertosick EA, Sarcona J et al. Primary urethral cancer: treatment patterns and associated outcomes. BJU Int 2020; 126: 359–366
Necchi A, Pederzoli F, Bandini M, Spiess PE. Revolutionizing care for rare genitourinary tumors. Nat Rev Urol 2021; 18: 69–70
Bandini M, Ahmed M, Basile G et al. A global approach to improving penile cancer care. Nat Rev Urol 2022; 19: 231–239
Peters M, Godfrey C, McInerney P, Munn Z, Tricco A, Khalil H. Guidance for the conduct of JBI scoping reviews chapter 11: scoping reviews scoping reviews. Underst Scoping Rev Defin Purp Process 2017; 18: 2119–2126
Dalbagni G, Zhang ZF, Lacombe L, Herr HW. Male urethral carcinoma: analysis of treatment outcome. Urology 1999; 53: 1126–1132
Dayyani F, Hoffman K, Eifel P et al. Management of advanced primary urethral carcinomas. BJU Int 2014; 114: 25–31
Dayyani F, Pettaway CA, Kamat AM, Munsell MF, Sircar K, Pagliaro LC. Retrospective analysis of survival outcomes and the role of cisplatin‐based chemotherapy in patients with urethral carcinomas referred to medical oncologists. Urol Oncol Semin Orig Investig 2013; 31: 1171–1177
Derksen JW, Visser O, de la Rivière GB, Meuleman EJ, Heldeweg EA, Lagerveld BW. Primary urethral carcinoma in females: an epidemiologic study on demographical factors, histological types, tumour stage and survival. World J Urol 2013; 31: 147–153
Desai S, Libertino JA, Zinman L. Primary carcinoma of the female urethra. J Urol 1973; 110: 693–695
DiMarco DS, DiMarco CS, Zincke H et al. Surgical treatment for local control of female urethral carcinoma. Urol Oncol Semin Orig Investig 2004; 22: 404–409
Dimarco DS, Dimarco CS, Zincke H et al. Outcome of surgical treatment for primary malignant melanoma of the female urethra. J Urol 2004; 171: 765–767
Dinney CPN, Johnson DE, Swanson DA, Babaian RJ, Von Eschenbach AC. Therapy and prognosis for male anterior urethral carcinoma: an update. Urology 1994; 43: 506–514
Eisenberger MA. Chemotherapy for carcinomas of the penis and urethra. Urol Clin North Am 1992; 19: 333–338
Eng TY, Naguib M, Galang T, Fuller CD. Retrospective study of the treatment of urethral cancer. Am J Clin Oncol Cancer Clin Trials 2003; 26: 558–562
Ahmed K, Dasgupta R, Vats A et al. Urethral diverticular carcinoma: an overview of current trends in diagnosis and management. Int Urol Nephrol 2010; 42: 331–341
Farrer JH, Lupu AN. Carcinoma of deep male urethra. Urology 1984; 24: 527–531
Foens CS, Hussey DH, Staples JJ, Fred Doornbos J, Wen BC, Vigliotti AP. A comparison of the roles of surgery and radiation therapy in the management of carcinoma of the female urethra. Int J Radiat Oncol Biol Phys 1991; 21: 961–968
Gakis G, Bruins HM, Cathomas R et al. European Association of Urology guidelines on primary urethral Carcinoma‐2020 update. Eur Urol Oncol 2020; 3: 424–432
Gakis G, Efstathiou JA, Daneshmand S et al. Oncological outcomes of patients with concomitant bladder and urethral carcinoma. Urol Int 2016; 97: 134–141
Gakis G, Schubert T, Morgan TM et al. The prognostic effect of salvage surgery and radiotherapy in patients with recurrent primary urethral carcinoma. Urol Oncol Semin Orig Investig 2018; 36: 10.e7–14
Garden AS, Zagars GK, Delclos L. Primary carcinoma of the female urethra results of radiation. Therapy 1989; 71: 3102–3108
Gheiler EL, Tefilli MV, Tiguert R, De Oliveira JG, Pontes JE, Wood DP. Management of primary urethral cancer. Urology 1998; 52: 487–493
Gillitzer R, Hampel C, Wiesner C, Hadaschik B, Thüroff J. Single‐institution experience with primary tumours of the male urethra. BJU Int 2008; 101: 964–968
Gingu C, Patrascoiu S, Surcel C et al. Primary carcinoma of the male urethra – diagnosis and treatment. Eur Urol Suppl 2011; 10: 626
Grabstald H. Tumors of the urethra in men and women. Cancer 1973; 4: 72–75
Anderson KA, Mcaninch JW. Primary squamous cell carcinoma of anterior male urethra. Int Urol Nephrol 1987; 19: 423–427
Grigsby PW, Corn BW. Localized urethral tumors in women: Indications for conservative versus exenterative therapies. J Urol 1992; 147: 1516–1520
Grigsby PW. Carcinoma of the urethra in women. Int J Radiat Oncol Biol Phys 1998; 41: 535–541
Guo H, Peng X, Jin C, Wang L, Chen F, Sa Y. Lichen sclerosus accompanied by urethral squamous cell carcinoma: a retrospective study from a urethral referral center. Am J Mens Health 2018; 12: 1692–1699
Hahn P, Krepart G, Malaker K. Carcinoma of female urethra. Urology 1991; 37: 106–108
Hakenberg OW, Franke HJ, Froehner M, Wirth MP. The treatment of primary urethral carcinoma ‐ the dilemmas of a rare condition: experience with partial urethrectomy and adjuvant chemotherapy. Onkologie 2001; 24: 48–52
Hedden RJ, Husseinzadeh N, Bracken RB. Bladder sparing surgery for locally advanced female urethral cancer. J Urol 1993; 150: 1135–1137
Heysek RV, Parsons JT, Drylie DM, Million RR. Carcinoma of the male urethra. J Urol 1985; 134: 753–755
Hopkins SC, Nag SK, Soloway MS. Primary carcinoma of male urethra. Urology 1984; 23: 128–133
Hopkins SC, Vider M, Nag SK, Tai DL, Soloway MS. Carcinoma of the female urethra: reassessment of modes of therapy. J Urol 1983; 129: 958–961
Iborra F, Murez T, Millet I, Serre I, Poinas G, Thuret R. Les cancers primitifs de l'urètre. Oncologie 2014; 16: 187–192
Blick C, Sahdev V, Mitra A, Nigam R, Muneer A. The contemporary management of primary urethral carcinoma. J Clin Urol 2015; 8: 412–419
Iborra F, Rigaud J, Bastide C, Mottet N. Treatment of primary urethral carcinoma. Guidelines from the French urological association. Cancer committee. Prog Urol 2009; 19: 170–175
Ichihara K, Masumori N, Kitamura H, Hasegawa T, Tsukamoto T. Clinical outcomes of urothelial carcinoma of the prostate detected in radical cystectomy specimens. Int J Clin Oncol 2014; 19: 152–156
Jo J‐C, Lee J‐L, Park S et al. Primary urethral cancer: a retrospective analysis of 27 patients at a single institute. Ann Oncol 2012; 23: xi141–xi142
Johnson DEOJR. Primary carcinoma of female urethra. Urology 1983; 21: 42–45
Kamat MR, Kulkarni JN, Dhumale RG. Primary carcinoma of female urethra: review of 20 cases. J Surg Oncol 1981; 16: 105–109
Kang M, Jeong CW, Kwak C, Kim HH, Ku JH. Survival outcomes and predictive factors for female urethral cancer: long‐term experience with Korean patients. J Korean Med Sci 2015; 30: 1143–1149
Karnes RJ, Breau RH, Lightner DJ. Surgery for urethral cancer. Urol Clin North Am 2010; 37: 445–457
Kent M, Zinman L, Girshovich L, Sands J, Vanni A. Combined chemoradiation as primary treatment for invasive male urethral cancer. J Urol 2015; 193: 532–537
Konnak JW. Conservative management of low grade neoplasms of the male urethra: a preliminary report. J Urol 1980; 123: 175–177
Koontz BF, Lee WR. Carcinoma of the urethra: radiation oncology. Urol Clin North Am 2010; 37: 459–466
Bracken RB, Johnson DE, Miller LF, Ayala AG, Gomez JJ, Rutledge F. Primary carcinoma of the female urethra. Obstet Gynecol Surv 1977; 32: 118–119
Krieg R, Hoffman R. Current management of unusual genitourinary cancers part 2: urethral cancer. Oncology 1999; 13: 1511–1520
Lupi G, Panici PB, Regazzoni M, Pizzocaro G, Lupi G. II carcinoma primitivo dell'uretra femminile. Urologia 1980; 47: 808–813
Mayer R, Fowler JE, Clayton M. Localized urethral cancer in women. Cancer 1987; 60: 1548–1551
Moinuddin Ali M, Klein FA, Hazra TA. Primary female urethral carcinoma. Cancer 1988; 62: 54–57
Mullin EM, Anderson EE, Paulson DF. Carcinoma of the male urethra. J Urol 1974; 112: 610–613
Narayan PKB. Surgical treatment of female urethral carcinoma. Urol Clin North Am 1992; 19: 373–382
Olaru V, Baston C, Gingu C et al. Primary urethral carcinoma: outcomes, differences and treatment modalities – results from a single center retrospective study. Eur Urol Suppl 2019; 18: e2403
Patel AJ, Vincent JN, Eng TY. Clinical outcomes of primary urethral cancer treated with multimodality therapy: a single institution experience. Int J Radiat Oncol 2013; 87: S402
Peterson DT, Dockerty MB, Utz DC, Symmonds RE. The peril of primary carcinoma of the urethra in women. J Urol 1973; 110: 72–75
Peyton CC, Azizi M, Chipollini J et al. Survival outcomes associated with female primary urethral carcinoma: review of a single institutional experience. Clin Genitourin Cancer 2018; 16: e1003–e1013
Cahn DB, Handorf E, Ristau BT et al. Contemporary practice patterns and survival outcomes for locally advanced urethral malignancies: a National Cancer Database Analysis. Urol Oncol Semin Orig Investig 2017; 35: 670.e15–21
Poon S, Glickman L, Moses K et al. Contemporary outcomes with primary male urethral carcinoma. J Urol 2012; 187: e272–e273
Rabbani F. Prognostic factors in male urethral cancer. Cancer 2011; 117: 2426–2434
Ray B, Canto AR, Whitmore WF. Experience with primary carcinoma of the male urethra. J Urol 1977; 117: 591–594
Ryan Farrell M, Xu JT, Vanni AJ. Current perspectives on the diagnosis and management of primary urethral cancer: a systematic review. Res Reports Urol 2021; 13: 325–334
Sailer SL, Shipley WU, Wang CC. Carcinoma of the female urethra: a review of results with radiation therapy. J Urol 1988; 140: 1–5
Sakashita S, Kashiwagi A, Nakanishi S, Ishii D, Hisajima S, Koyanagi T. Female primary urethral tumors. Hinyokika Kiyo 1984; 30: 935–940
Sharma DN, Gandhi AK, Bhatla N, Kumar S, Rath GK. High‐dose‐rate interstitial brachytherapy for female peri‐urethral cancer. J Contemp Brachytherapy 2016; 8: 41–47
Smith Y, Hadway P, Ahmed S, Perry MJ, Corbishley CM, Watkin NA. Penile‐preserving surgery for male distal urethral carcinoma. BJU Int 2007; 100: 82–87
Son CH, Liauw SL, Hasan Y, Solanki AA. Optimizing the role of surgery and radiation therapy in urethral cancer based on histology and disease extent. Int J Radiat Oncol Biol Phys 2018; 102: 304–313
Srinivas V, Khan SA. Female urethral cancer – an overview aetiology. Int Urol Nephrol 1987; 19: 423–427
Castiglione F, Alnajjar HM, Christodoulidou M et al. Primary squamous cell carcinoma of the male proximal urethra: outcomes from a single centre. Eur Urol Focus 2021; 7: 163–169
Stewart PH, Anderson CK, Williams RE, Clark PB. Urethral tumours. Br J Urol 1978; 50: 583–585
Stone BV, Hill SC, Moses KA. The effect of centralization of care on overall survival in primary urethral cancer. Urol Oncol Semin Orig Investig 2021; 39: 133.e17–26
Sui W, RoyChoudhury A, Wenske S, Decastro GJ, McKiernan JM, Anderson CB. Outcomes and prognostic factors of primary urethral cancer. Urology 2017; 100: 180–186
Thyavihally YB, Tongaonkar HB, Srivastava SK, Mahantshetty U, Kumar P, Raibhattanavar SG. Clinical outcome of 36 male patients with primary urethral carcinoma: a single center experience. Int J Urol 2006; 13: 716–720
Thyavihally YB, Wuntkal R, Bakshi G, Uppin S, Tongaonkar HB. Primary carcinoma of the female urethra: single center experience of 18 cases. Jpn J Clin Oncol 2005; 35: 84–87
Touyama H, Mukouyama H, Miyazato T, Koyama Y, Hatano T, Ogawa Y. Primary carcinoma of the female urethra: report of five cases. Hinyokika Kiyo 1997; 45: 303–305
Traboulsi SL, Witjes JA, Kassouf W. Contemporary management of primary distal urethral cancer. Urol Clin North Am 2016; 43: 493–503
Trabulsi EJ, Hoffman‐Censits J. Chemotherapy for penile and urethral carcinoma. Urol Clin North Am 2010; 37: 467–474
Tritschler S, Lellig K, Roosen A, Horng A, Stief C. Organ and function preservation in urethral cancer. Urologe A 2014; 53: 1310–1315
Champ CE, Hegarty SE, Shen X et al. Prognostic factors and outcomes after definitive treatment of female urethral cancer: a population‐based analysis. Urology 2012; 80: 374–382
Turner AG, Hendry WF. Primary carcinoma of the female urethra. Br J Urol 1980; 52: 549–554
Wang EH, Yu JB. Chemoradiation therapy for organ preservation in localized male urethral carcinoma. Oncology 2016; 30: 520–523
Wei Y, Wu YP, Xu N et al. Sex‐related differences in clinicopathological features and survival of patients with primary urethral carcinoma: a population‐based study. Onco Targets Ther 2017; 10: 3381–3389
Wenzel M, Nocera L, Collà Ruvolo C et al. Sex‐related differences include stage, histology, and survival in urethral cancer patients. Clin Genitourin Cancer 2021; 19: 135–143
Wiener JS, Liu ET, Walther PJ. Oncogenic human papillomavirus type 16 is associated with squamous cell cancer of the male urethra. Cancer Res 1992; 52: 5018–5023
Zeidman EJ, Desmond P, Thompson IM. Surgical treatment of carcinoma of the male urethra. Urol Clin North Am 1992; 19: 359–372
Zeigermann JH. Cancer of the female urethra. 1973: 143–8
Zhang C, Wang S, Deutsch I. A SEER database analysis of urethral cancer management. Int J Radiat Oncol 2012; 84: S425
Zi H, Gao L, Yu Z et al. Nomograms for predicting long‐term overall survival and cancer‐specific survival in patients with primary urethral carcinoma: a population‐based study. Am Joint Committee Cancer 2020; 52: 287–300.
Grivas PD, Davenport M, Montie JE, Kunju LP, Feng F, Weizer AZ. Urethral cancer. Hematol Oncol Clin North Am 2012; 26: 1291–1314
Dalbagni C, Zhang ZF, Lacombi‐ L, Hi‐Rr HW. Female urethral carcinoma: an analysis of treatment outcome and a plea for a standardized management strategy. Br J Urol 1998; 82: 835–841
Janisch F, Abufaraj M, Fajkovic H et al. Current disease management of primary urethral carcinoma. Eur Urol Focus 2019; 5: 722–734
Zinman LN, Vanni AJ. Management of proximal primary urethral cancer: should multidisciplinary therapy be the gold standard? Urol Clin North Am 2016; 43: 505–513
Zhang AH, Wang P, Sun H, Yan GL, Han Y, Wang XJ. High‐throughput ultra‐performance liquid chromatography‐mass spectrometry characterization of metabolites guided by a bioinformatics program. Mol BioSyst 2013; 9: 2259–2265
Milosevic MF, Warde PR, Banerjee D et al. Urethral carcinoma in women: results of treatment with primary radiotherapy. Radiother Oncol 2000; 56: 29–35
Cohen MS, Triaca V, Billmeyer B et al. Coordinated chemoradiation therapy with genital preservation for the treatment of primary invasive carcinoma of the male urethra. J Urol 2008; 179: 536–541
Gakis G, Morgan TM, Efstathiou JA et al. Prognostic factors and outcomes in primary urethral cancer: results from the international collaboration on primary urethral carcinoma. World J Urol 2016; 34: 97–103
Gakis G, Witjes JA, Compérat E et al. EAU guidelines on primary urethral carcinoma. Eur Urol 2013; 64: 823–830