Estrogenic, androgenic, and genotoxic activities of zearalenone and deoxynivalenol in in vitro bioassays including exogenous metabolic activation.
In vitro bioassays
Deoxynivalenol
Effect-based methods
Endocrine receptors
Metabolism
Micronuclei formation
Zearalenone
Journal
Mycotoxin research
ISSN: 1867-1632
Titre abrégé: Mycotoxin Res
Pays: Germany
ID NLM: 8807334
Informations de publication
Date de publication:
08 Apr 2024
08 Apr 2024
Historique:
received:
20
09
2023
accepted:
05
03
2024
revised:
27
02
2024
medline:
8
4
2024
pubmed:
8
4
2024
entrez:
8
4
2024
Statut:
aheadofprint
Résumé
Zearalenone (ZEN) and deoxynivalenol (DON) and their derivatives are well-known mycotoxins, which can occur not only in crops but also in water bodies, including drinking water sources. In vitro bioassays can be used to detect biological effects of hazardous compounds in water. To this, when studying biological effects and toxicity in vitro, metabolism is important to consider. In this study, ZEN, α-zearalenol (α-ZEL), DON, 3-acetyl DON, and 15-acetyl DON were evaluated in vitro for hormone receptor-mediated effects (estrogen receptor [ER] and androgen receptor [AR]) and genotoxicity (micronucleus assay) in the presence of an exogenous metabolic activation system (MAS). The ER bioassay proved to be a highly sensitive method to detect low concentrations of the ZEN compounds (EC
Identifiants
pubmed: 38587710
doi: 10.1007/s12550-024-00529-2
pii: 10.1007/s12550-024-00529-2
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Svenska Forskningsrådet Formas
ID : grants number 2018-00386
Organisme : Svenska Forskningsrådet Formas
ID : 2018-02256
Organisme : Svenska Forskningsrådet Formas
ID : 2019-02043
Informations de copyright
© 2024. The Author(s).
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