Concurrent inhibition of oncogenic and wild-type RAS-GTP for cancer therapy.


Journal

Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462

Informations de publication

Date de publication:
08 Apr 2024
Historique:
received: 28 06 2023
accepted: 16 02 2024
medline: 9 4 2024
pubmed: 9 4 2024
entrez: 8 4 2024
Statut: aheadofprint

Résumé

RAS oncogenes (collectively NRAS, HRAS and especially KRAS) are among the most frequently mutated genes in cancer, with common driver mutations occurring at codons 12, 13 and 61

Identifiants

pubmed: 38589574
doi: 10.1038/s41586-024-07205-6
pii: 10.1038/s41586-024-07205-6
doi:

Banques de données

ClinicalTrials.gov
['NCT05379985']

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

© 2024. The Author(s).

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Auteurs

Matthew Holderfield (M)

Revolution Medicines, Redwood City, CA, USA.

Bianca J Lee (BJ)

Revolution Medicines, Redwood City, CA, USA.

Jingjing Jiang (J)

Revolution Medicines, Redwood City, CA, USA.

Aidan Tomlinson (A)

Revolution Medicines, Redwood City, CA, USA.

Kyle J Seamon (KJ)

Revolution Medicines, Redwood City, CA, USA.

Alessia Mira (A)

Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center, University of Torino, Torino, Italy.

Enrico Patrucco (E)

Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center, University of Torino, Torino, Italy.

Grace Goodhart (G)

Department of Surgery, University of Cincinnati, Cincinnati, OH, USA.

Julien Dilly (J)

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.

Yevgeniy Gindin (Y)

Revolution Medicines, Redwood City, CA, USA.

Nuntana Dinglasan (N)

Revolution Medicines, Redwood City, CA, USA.

Yingyun Wang (Y)

Revolution Medicines, Redwood City, CA, USA.

Lick Pui Lai (LP)

Revolution Medicines, Redwood City, CA, USA.

Shurui Cai (S)

Revolution Medicines, Redwood City, CA, USA.

Lingyan Jiang (L)

Revolution Medicines, Redwood City, CA, USA.

Nicole Nasholm (N)

Revolution Medicines, Redwood City, CA, USA.

Nataliya Shifrin (N)

Revolution Medicines, Redwood City, CA, USA.

Cristina Blaj (C)

Revolution Medicines, Redwood City, CA, USA.

Harshit Shah (H)

Revolution Medicines, Redwood City, CA, USA.

James W Evans (JW)

Revolution Medicines, Redwood City, CA, USA.

Nilufar Montazer (N)

Revolution Medicines, Redwood City, CA, USA.

Oliver Lai (O)

Revolution Medicines, Redwood City, CA, USA.

Jade Shi (J)

Revolution Medicines, Redwood City, CA, USA.

Ethan Ahler (E)

Revolution Medicines, Redwood City, CA, USA.

Elsa Quintana (E)

Revolution Medicines, Redwood City, CA, USA.

Stephanie Chang (S)

Revolution Medicines, Redwood City, CA, USA.

Anthony Salvador (A)

Revolution Medicines, Redwood City, CA, USA.

Abby Marquez (A)

Revolution Medicines, Redwood City, CA, USA.

Jim Cregg (J)

Revolution Medicines, Redwood City, CA, USA.

Yang Liu (Y)

Revolution Medicines, Redwood City, CA, USA.

Anthony Milin (A)

Revolution Medicines, Redwood City, CA, USA.

Anqi Chen (A)

Revolution Medicines, Redwood City, CA, USA.

Tamar Bar Ziv (TB)

Revolution Medicines, Redwood City, CA, USA.

Dylan Parsons (D)

Revolution Medicines, Redwood City, CA, USA.

John E Knox (JE)

Revolution Medicines, Redwood City, CA, USA.

Jennifer E Klomp (JE)

Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Jennifer Roth (J)

Broad Institute of MIT and Harvard, Cambridge, MA, USA.

Matthew Rees (M)

Broad Institute of MIT and Harvard, Cambridge, MA, USA.

Melissa Ronan (M)

Broad Institute of MIT and Harvard, Cambridge, MA, USA.

Antonio Cuevas-Navarro (A)

Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Feng Hu (F)

Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Piro Lito (P)

Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Department of Medicine, Weill Cornell Medical College, New York, NY, USA.

David Santamaria (D)

Molecular Mechanisms of Cancer Program, Centro de Investigación del Cáncer, CSIC-Universidad de Salamanca, Salamanca, Spain.

Andrew J Aguirre (AJ)

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Harvard Medical School, Boston, MA, USA.
Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.

Andrew M Waters (AM)

Department of Surgery, University of Cincinnati, Cincinnati, OH, USA.
Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Department of Cancer Biology, University of Cincinnati, Cincinnati, OH, USA.

Channing J Der (CJ)

Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Chiara Ambrogio (C)

Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center, University of Torino, Torino, Italy.

Zhengping Wang (Z)

Revolution Medicines, Redwood City, CA, USA.

Adrian L Gill (AL)

Revolution Medicines, Redwood City, CA, USA.

Elena S Koltun (ES)

Revolution Medicines, Redwood City, CA, USA.

Jacqueline A M Smith (JAM)

Revolution Medicines, Redwood City, CA, USA. jan@revmed.com.

David Wildes (D)

Revolution Medicines, Redwood City, CA, USA. pete@revmed.com.

Mallika Singh (M)

Revolution Medicines, Redwood City, CA, USA. msingh@revmed.com.

Classifications MeSH