Mechanisms of Cardiovascular Calcification and Experimental Models: Impact of Vitamin K Antagonists.

anticoagulation atherosclerosis calcification vitamin K

Journal

Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588

Informations de publication

Date de publication:
29 Feb 2024
Historique:
received: 16 01 2024
revised: 22 02 2024
accepted: 27 02 2024
medline: 9 4 2024
pubmed: 9 4 2024
entrez: 9 4 2024
Statut: epublish

Résumé

Cardiovascular calcification is a multifactorial and complex process involving an array of molecular mechanisms eventually leading to calcium deposition within the arterial walls. This process increases arterial stiffness, decreases elasticity, influences shear stress events and is related to an increased risk of morbidity and mortality associated with cardiovascular disease. In numerous in vivo and in vitro models, warfarin therapy has been shown to cause vascular calcification in the arterial wall. However, the exact mechanisms of calcification formation with warfarin remain largely unknown, although several molecular pathways have been identified. Circulating miRNA have been evaluated as biomarkers for a wide range of cardiovascular diseases, but their exact role in cardiovascular calcification is limited. This review aims to describe the current state-of-the-art research on the impact of warfarin treatment on the development of vascular calcification and to highlight potential molecular targets, including microRNA, within the implicated pathways.

Identifiants

pubmed: 38592207
pii: jcm13051405
doi: 10.3390/jcm13051405
pii:
doi:

Types de publication

Journal Article Review

Langues

eng

Auteurs

Chiara Siracusa (C)

Department of Medical and Surgical Sciences, Magna Graecia University, 88100 Catanzaro, Italy.

Annarita Carino (A)

Department of Medical and Surgical Sciences, Magna Graecia University, 88100 Catanzaro, Italy.

Nicole Carabetta (N)

Department of Medical and Surgical Sciences, Magna Graecia University, 88100 Catanzaro, Italy.

Marzia Manica (M)

Department of Medical and Surgical Sciences, Magna Graecia University, 88100 Catanzaro, Italy.

Jolanda Sabatino (J)

Department of Experimental and Clinical Medicine, Magna Graecia University, 88100 Catanzaro, Italy.

Eleonora Cianflone (E)

Department of Medical and Surgical Sciences, Magna Graecia University, 88100 Catanzaro, Italy.

Isabella Leo (I)

Department of Experimental and Clinical Medicine, Magna Graecia University, 88100 Catanzaro, Italy.

Antonio Strangio (A)

Department of Experimental and Clinical Medicine, Magna Graecia University, 88100 Catanzaro, Italy.

Daniele Torella (D)

Department of Experimental and Clinical Medicine, Magna Graecia University, 88100 Catanzaro, Italy.

Salvatore De Rosa (S)

Department of Medical and Surgical Sciences, Magna Graecia University, 88100 Catanzaro, Italy.

Classifications MeSH