Rab7-dependent regulation of goblet cell protein CLCA1 modulates gastrointestinal homeostasis.
CLCA1
Rab7 GTPase
goblet cells
human
immunology
inflammation
inflammatory bowel disease
mouse
mucus
ulcerative colitis
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
09 Apr 2024
09 Apr 2024
Historique:
medline:
9
4
2024
pubmed:
9
4
2024
entrez:
9
4
2024
Statut:
epublish
Résumé
Inflammation in ulcerative colitis is typically restricted to the mucosal layer of distal gut. Disrupted mucus barrier, coupled with microbial dysbiosis, has been reported to occur prior to the onset of inflammation. Here, we show the involvement of vesicular trafficking protein Rab7 in regulating the colonic mucus system. We identified a lowered Rab7 expression in goblet cells of colon during human and murine colitis. In vivo Rab7 knocked down mice (Rab7
Identifiants
pubmed: 38593125
doi: 10.7554/eLife.89776
pii: 89776
doi:
pii:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Department of Biotechnology, Ministry of Science and Technology, India
ID : BT/PR45284/CMD/150/9/2022
Informations de copyright
© 2023, Gaur et al.
Déclaration de conflit d'intérêts
PG, YR, BS, MM, VF, GM, AS, SC, ST, SY, AP, YM, AB, VA, CS No competing interests declared
Références
Int J Environ Res Public Health. 2020 Oct 19;17(20):
pubmed: 33086688
J Biol Chem. 2009 May 1;284(18):12110-24
pubmed: 19265192
PLoS One. 2010 Aug 18;5(8):e12238
pubmed: 20805871
Gut Microbes. 2010 Jan;1(1):51-54
pubmed: 21327117
Int J Surg Pathol. 2012 Jun;20(3):252-6
pubmed: 22169970
Gut. 2019 Dec;68(12):2142-2151
pubmed: 30914450
J Biol Chem. 2002 Dec 6;277(49):47248-56
pubmed: 12374796
World J Gastroenterol. 2005 Feb 28;11(8):1131-40
pubmed: 15754393
Nat Rev Immunol. 2016 Oct;16(10):639-49
pubmed: 27498766
Dig Endosc. 2016 Jan;28(1):67-74
pubmed: 26418574
Food Funct. 2021 Apr 26;12(8):3476-3492
pubmed: 33900330
Mucosal Immunol. 2015 Jul;8(4):712-9
pubmed: 25872481
Cell Rep. 2019 Dec 10;29(11):3522-3538.e7
pubmed: 31825833
Cell Rep. 2020 Jun 9;31(10):107733
pubmed: 32521258
Biochem Soc Trans. 2018 Jun 19;46(3):683-690
pubmed: 29784647
Gastroenterology. 1988 Jun;94(6):1390-403
pubmed: 3360261
Differentiation. 2009 Jan;77(1):84-94
pubmed: 19281767
J Proteome Res. 2009 Jul;8(7):3549-57
pubmed: 19432394
BMC Bioinformatics. 2013 Apr 15;14:128
pubmed: 23586463
Nat Comput Sci. 2021 Aug;1(8):511-515
pubmed: 38217242
J Immunol. 2016 Nov 15;197(10):3792-3805
pubmed: 27742832
J Biol Chem. 2019 Nov 8;294(45):17075-17089
pubmed: 31570526
Cell Mol Gastroenterol Hepatol. 2022;13(1):219-232
pubmed: 34418586
J Cell Sci. 2004 Jun 1;117(Pt 13):2687-97
pubmed: 15138286
Sci Adv. 2021 Jan 8;7(2):
pubmed: 33523982
J Biol Chem. 2013 Jan 11;288(2):1135-49
pubmed: 23188822
Dig Dis Sci. 2013 Mar;58(3):668-77
pubmed: 23329012
J Biomed Sci. 2016 Oct 6;23(1):70
pubmed: 27716280
J Nutr Biochem. 2022 Jan;99:108858
pubmed: 34587540
Int J Mol Med. 2009 Dec;24(6):829-35
pubmed: 19885626
Nat Rev Neurosci. 2013 Mar;14(3):161-76
pubmed: 23361386
Cells. 2016 Aug 18;5(3):
pubmed: 27548222
Curr Protoc. 2021 Mar;1(3):e90
pubmed: 33780170
J Cell Biol. 2018 Sep 3;217(9):3141-3159
pubmed: 29907658
EBioMedicine. 2018 Jul;33:134-143
pubmed: 29885864
Bioinformatics. 2016 Sep 15;32(18):2847-9
pubmed: 27207943
Gut. 2006 Feb;55(2):205-11
pubmed: 16188921
Physiol Rev. 2011 Jan;91(1):119-49
pubmed: 21248164
J Clin Gastroenterol. 2013 Feb;47(2):106-11
pubmed: 23164684
Am J Physiol Gastrointest Liver Physiol. 2001 May;280(5):G922-9
pubmed: 11292601
Nucleic Acids Res. 2016 Jul 8;44(W1):W90-7
pubmed: 27141961
Nanoscale. 2019 Mar 14;11(11):4970-4986
pubmed: 30839018
Dev Cell. 2020 Apr 20;53(2):169-184.e11
pubmed: 32243783
Tissue Barriers. 2013 Dec 1;1(5):e26938
pubmed: 24868497
Proc Natl Acad Sci U S A. 2007 Aug 21;104(34):13780-5
pubmed: 17699621
Nature. 2011 Jun 15;474(7351):298-306
pubmed: 21677746
Open Biol. 2017 Jun;7(6):
pubmed: 28659381