Behavioral Science: Enhancing Our Approach to the Development of Effective Additional Risk Minimization Strategies.


Journal

Drug safety
ISSN: 1179-1942
Titre abrégé: Drug Saf
Pays: New Zealand
ID NLM: 9002928

Informations de publication

Date de publication:
09 Apr 2024
Historique:
accepted: 07 03 2024
medline: 10 4 2024
pubmed: 10 4 2024
entrez: 9 4 2024
Statut: aheadofprint

Résumé

Additional risk minimization strategies may be required to assure a positive benefit-risk balance for some therapeutic products associated with serious adverse drug reactions/risks of use, without which these products may be otherwise unavailable to patients. The goals of risk minimization strategies are often fundamentally to influence the behavior of healthcare professionals (HCPs) and/or patients and can include appropriate patient selection, provision of education and counselling, appropriate medication use, adverse drug reaction monitoring, and adoption of other elements to assure safe use, such as pregnancy prevention. Current approaches to additional risk minimization strategy development rely heavily on information provision, without full consideration of the contextual factors and multi-level influences on patient and HCP behaviors that impact adoption and long-term adherence to these interventions. Application of evidence-based behavioral science methods are urgently needed to improve the quality and effectiveness of these strategies. Evidence from the fields of adherence, health promotion, and drug utilization research underscores the value and necessity for using established behavioral science frameworks and methods if we are to achieve clinical safety goals for patients. The current paper aims to enhance additional risk minimization strategy development and effectiveness by considering how a behavioral science approach can be applied, drawing from evidence in understanding of engagement with pharmaceutical medicines as well as wider public health interventions for patients and HCPs.

Identifiants

pubmed: 38594553
doi: 10.1007/s40264-024-01420-w
pii: 10.1007/s40264-024-01420-w
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

© 2024. The Author(s), under exclusive licence to Springer Nature Switzerland AG.

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Auteurs

Joanne Treacy (J)

Bristol Myers Squibb, Lawrenceville, NJ, USA.

Elaine H Morrato (EH)

Parkinson School of Health Sciences and Public Health, Loyola University Chicago, Chicago, IL, USA.

Robert Horne (R)

Spoonful of Sugar Ltd, University College London Business Company, Brighton and Hove, UK.

Michael S Wolf (MS)

Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.

Ameet Bakhai (A)

The Royal Free and University College Medical School, London, UK.

Marie-Claire Wilson (MC)

Axian Consulting, Ltd., Cambridge, UK.

Mark Lightowler (M)

Centre for Pharmaceutical Medicine Research, Institute of Pharmaceutical Science, King's College London, London, UK.

Sibel Guerler (S)

Bristol Myers Squibb, Lawrenceville, NJ, USA.

Jeremy Jokinen (J)

Bristol Myers Squibb, Lawrenceville, NJ, USA. jeremy.jokinen@bms.com.

Classifications MeSH