Impact of an irreversible β-galactosylceramidase inhibitor on the lipid profile of zebrafish embryos.

Galactosylceramidase Krabbe disease Lipidomics Molecular modeling Zebrafish

Journal

Computational and structural biotechnology journal
ISSN: 2001-0370
Titre abrégé: Comput Struct Biotechnol J
Pays: Netherlands
ID NLM: 101585369

Informations de publication

Date de publication:
Dec 2024
Historique:
received: 10 01 2024
revised: 18 03 2024
accepted: 25 03 2024
medline: 10 4 2024
pubmed: 10 4 2024
entrez: 10 4 2024
Statut: epublish

Résumé

Krabbe disease is a sphingolipidosis characterized by the genetic deficiency of the acid hydrolase β-galactosylceramidase (GALC). Most of the studies concerning the biological role of GALC performed on Krabbe patients and

Identifiants

DOI: 10.1016/j.csbj.2024.03.023 PMID: 38596316 PMC: PMC11002810
pubmed: 38596316
doi: 10.1016/j.csbj.2024.03.023
pii: S2001-0370(24)00076-X
pmc: PMC11002810
doi:

Types de publication

Journal Article

Langues

eng

Pagination

1397-1407

Informations de copyright

© 2024 The Authors.

Déclaration de conflit d'intérêts

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Auteurs

Jessica Guerra (J)

Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.

Mirella Belleri (M)

Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.

Giulia Paiardi (G)

Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.
Molecular and Cellular Modeling Group, Heidelberg Institute for Theoretical Studies, Germany.
Zentrum für Molekulare Biologie der Universität Heidelberg (ZMBH), DKFZ-ZMBH Alliance, Heidelberg, Germany.

Chiara Tobia (C)

Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.

Davide Capoferri (D)

Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.

Marzia Corli (M)

Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.

Elisa Scalvini (E)

Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.

Marco Ghirimoldi (M)

Department of Translational Medicine, University of Piemonte Orientale, Novara, Italy.
Center for Allergic and Autoimmune Diseases, University of Piemonte Orientale, Novara, Italy.

Marcello Manfredi (M)

Department of Translational Medicine, University of Piemonte Orientale, Novara, Italy.
Center for Allergic and Autoimmune Diseases, University of Piemonte Orientale, Novara, Italy.

Rebecca C Wade (RC)

Molecular and Cellular Modeling Group, Heidelberg Institute for Theoretical Studies, Germany.
Zentrum für Molekulare Biologie der Universität Heidelberg (ZMBH), DKFZ-ZMBH Alliance, Heidelberg, Germany.
Interdisciplinary Center for Scientific Computing (IWR), Heidelberg University, Heidelberg, Germany.

Marco Presta (M)

Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.
Consorzio Interuniversitario Biotecnologie (CIB), Unit of Brescia, Italy.

Luca Mignani (L)

Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.

Classifications MeSH