CCDC28A deficiency causes sperm head defects, reduced sperm motility and male infertility in mice.
CCDC28A
Knockout
Male infertility
Motility
Sperm head defects
Journal
Cellular and molecular life sciences : CMLS
ISSN: 1420-9071
Titre abrégé: Cell Mol Life Sci
Pays: Switzerland
ID NLM: 9705402
Informations de publication
Date de publication:
10 Apr 2024
10 Apr 2024
Historique:
received:
21
08
2023
accepted:
22
02
2024
revised:
20
02
2024
medline:
10
4
2024
pubmed:
10
4
2024
entrez:
10
4
2024
Statut:
epublish
Résumé
Mature spermatozoa with normal morphology and motility are essential for male reproduction. The epididymis has an important role in the proper maturation and function of spermatozoa for fertilization. However, factors related to the processes involved in spermatozoa modifications are still unclear. Here we demonstrated that CCDC28A, a member of the CCDC family proteins, is highly expressed in testes and the CCDC28A deletion leads to male infertility. We found CCDC28A deletion had a mild effect on spermatogenesis. And epididymal sperm collected from Ccdc28a
Identifiants
pubmed: 38597936
doi: 10.1007/s00018-024-05184-5
pii: 10.1007/s00018-024-05184-5
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
174Subventions
Organisme : the National Key Research and Development Program for Young Scientists
ID : 2022YFC2702300
Organisme : the National Natural Science Foundation of China
ID : 82201767
Organisme : the Project of the Shanghai Municipal Science and Technology Commission
ID : 21YF1418300
Organisme : the Project of the Shanghai Municipal Science and Technology Commission
ID : 21XD1420300
Informations de copyright
© 2024. The Author(s).
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