Tai chi, irisin and cognitive performance: a clinical and biological investigation in older adults.
Aging
Cognition
Irisin
Prevention
Tai Chi
Journal
Aging clinical and experimental research
ISSN: 1720-8319
Titre abrégé: Aging Clin Exp Res
Pays: Germany
ID NLM: 101132995
Informations de publication
Date de publication:
10 Apr 2024
10 Apr 2024
Historique:
received:
28
02
2024
accepted:
19
03
2024
medline:
10
4
2024
pubmed:
10
4
2024
entrez:
10
4
2024
Statut:
epublish
Résumé
Skeletal muscle is the main source of circulating irisin, both at rest and during physical activity. Previous studies have suggested that irisin can improve cognitive abilities. We explored whether six months of Tai Chi (TC) practice can modulate such a relationship in healthy older persons. This is a prospective clinical study to evaluate the effects of TC practice as compared with low intensity exercise (LI) and no exercise (NE) control groups on plasmatic irisin levels and cognitive performance. Forty-two healthy older persons were stratified into three groups according to physical activities. Biochemical assay and cognitive functions were assessed at the baseline and after six months. A significant change was found in circulating irisin levels in TC as compared with NE group (p = 0.050) across time. At six months in TC group irisin levels significantly correlated with a verbal memory test (p = 0.013) controlled by age and education. Our results suggest the potential benefits for cognitive health of TC practice by irisin levels modulation.
Sections du résumé
BACKGROUND
BACKGROUND
Skeletal muscle is the main source of circulating irisin, both at rest and during physical activity. Previous studies have suggested that irisin can improve cognitive abilities.
AIMS
OBJECTIVE
We explored whether six months of Tai Chi (TC) practice can modulate such a relationship in healthy older persons.
METHODS
METHODS
This is a prospective clinical study to evaluate the effects of TC practice as compared with low intensity exercise (LI) and no exercise (NE) control groups on plasmatic irisin levels and cognitive performance. Forty-two healthy older persons were stratified into three groups according to physical activities. Biochemical assay and cognitive functions were assessed at the baseline and after six months.
RESULTS
RESULTS
A significant change was found in circulating irisin levels in TC as compared with NE group (p = 0.050) across time. At six months in TC group irisin levels significantly correlated with a verbal memory test (p = 0.013) controlled by age and education.
CONCLUSION
CONCLUSIONS
Our results suggest the potential benefits for cognitive health of TC practice by irisin levels modulation.
Identifiants
pubmed: 38598000
doi: 10.1007/s40520-024-02743-5
pii: 10.1007/s40520-024-02743-5
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
90Informations de copyright
© 2024. The Author(s).
Références
Boccardi V, Comanducci C, Baroni M, Mecocci P (2017) Of Energy and Entropy: the Ineluctable Impact of Aging in Old Age Dementia. Int J Mol Sci 18. https://doi.org/10.3390/IJMS18122672
Szychowska A, Drygas W (2022) Physical activity as a determinant of successful aging: a narrative review article. Aging Clin Exp Res 34:1209–1214. https://doi.org/10.1007/S40520-021-02037-0
doi: 10.1007/S40520-021-02037-0
pubmed: 34873677
Angulo J, El Assar M, Álvarez-Bustos A, Rodríguez-Mañas L (2020) Physical activity and exercise: strategies to manage frailty. Redox Biol 35. https://doi.org/10.1016/J.REDOX.2020.101513
Field T (2011) Tai Chi research review. Complement Ther Clin Pract 17:141–146. https://doi.org/10.1016/J.CTCP.2010.10.002
doi: 10.1016/J.CTCP.2010.10.002
pubmed: 21742279
Jasim N, Balakirishnan D, Zhang H et al (2023) Effects and mechanisms of Tai Chi on mild cognitive impairment and early-stage dementia: a scoping review. Syst Rev 12:1–26. https://doi.org/10.1186/S13643-023-02358-3/TABLES/8
doi: 10.1186/S13643-023-02358-3/TABLES/8
Makiel K, Suder A, Targosz A et al (2023) Effect of Exercise interventions on Irisin and Interleukin-6 concentrations and indicators of Carbohydrate Metabolism in males with metabolic syndrome. J Clin Med 12:369. https://doi.org/10.3390/JCM12010369/S1
doi: 10.3390/JCM12010369/S1
pubmed: 36615169
pmcid: 9820823
Lin Y, Fan R, Hao Z et al (2022) The Association between physical activity and insulin level under different levels of lipid indices and serum uric acid. Front Physiol 13:809669. https://doi.org/10.3389/FPHYS.2022.809669/BIBTEX
doi: 10.3389/FPHYS.2022.809669/BIBTEX
pubmed: 35185617
pmcid: 8847671
Young MF, Valaris S, Wrann CD (2019) A role for FNDC5/Irisin in the Beneficial effects of Exercise on the brain and in neurodegenerative diseases. Prog Cardiovasc Dis 62:172. https://doi.org/10.1016/J.PCAD.2019.02.007
doi: 10.1016/J.PCAD.2019.02.007
pubmed: 30844383
pmcid: 6955153
Piccirilli M, Pigliautile M, Arcelli P et al (2019) Improvement in cognitive performance and mood in healthy older adults: a multimodal approach. Eur J Ageing 16:327–336. https://doi.org/10.1007/S10433-019-00503-3
doi: 10.1007/S10433-019-00503-3
pubmed: 31543727
pmcid: 6728443
Solloway MR, Taylor SL, Shekelle PG et al (2016) An evidence map of the effect of Tai Chi on health outcomes. Syst Rev 5:1. https://doi.org/10.1186/S13643-016-0300-Y
doi: 10.1186/S13643-016-0300-Y
Chen W, Li M, Li H et al (2023) Tai Chi for fall prevention and balance improvement in older adults: a systematic review and meta-analysis of randomized controlled trials. Front Public Health. https://doi.org/10.3389/FPUBH.2023.1236050/FULL . 11:
doi: 10.3389/FPUBH.2023.1236050/FULL
pubmed: 38419815
pmcid: 10771329
Kwon JH, Moon KM, Min KW (2020) Exercise-Induced myokines can explain the importance of physical activity in the Elderly: an overview. Healthcare 8: https://doi.org/10.3390/HEALTHCARE8040378
Li H, Wang F, Yang M et al (2021) The Effect of Irisin as a Metabolic Regulator and its therapeutic potential for obesity. Int J Endocrinol 2021. https://doi.org/10.1155/2021/6572342
Islam MR, Valaris S, Young MF et al (2021) Exercise hormone irisin is a critical regulator of cognitive function. Nat Metab 3:1058–1070. https://doi.org/10.1038/S42255-021-00438-Z
doi: 10.1038/S42255-021-00438-Z
pubmed: 34417591
pmcid: 10317538
Küster OC, Laptinskaya D, Fissler P et al (2017) Novel blood-based biomarkers of cognition, stress, and physical or cognitive training in older adults at risk of dementia: preliminary evidence for a role of BDNF, Irisin, and the Kynurenine Pathway. J Alzheimers Dis 59:1097–1111. https://doi.org/10.3233/JAD-170447
doi: 10.3233/JAD-170447
pubmed: 28731451
Tsai CL, Pai MC (2021) Circulating levels of Irisin in obese individuals at genetic risk for Alzheimer’s disease: correlations with amyloid-β, metabolic, and neurocognitive indices. Behav Brain Res 400. https://doi.org/10.1016/J.BBR.2020.113013
Pedersen BK (2019) Physical activity and muscle-brain crosstalk. Nat Rev Endocrinol 15:383–392. https://doi.org/10.1038/S41574-019-0174-X
doi: 10.1038/S41574-019-0174-X
pubmed: 30837717