Ex vivo, in vivo and in silico studies of corneal biomechanics: a systematic review.
Computational modelling
Cornea
Experimental tests
Finite element model
Human cornea
Journal
Physical and engineering sciences in medicine
ISSN: 2662-4737
Titre abrégé: Phys Eng Sci Med
Pays: Switzerland
ID NLM: 101760671
Informations de publication
Date de publication:
10 Apr 2024
10 Apr 2024
Historique:
received:
09
11
2023
accepted:
08
02
2024
medline:
10
4
2024
pubmed:
10
4
2024
entrez:
10
4
2024
Statut:
aheadofprint
Résumé
Healthy cornea guarantees the refractive power of the eye and the protection of the inner components, but injury, trauma or pathology may impair the tissue shape and/or structural organization and therefore its material properties, compromising its functionality in the ocular visual process. It turns out that biomechanical research assumes an essential role in analysing the morphology and biomechanical response of the cornea, preventing pathology occurrence, and improving/optimising treatments. In this review, ex vivo, in vivo and in silico methods for the corneal mechanical characterization are reported. Experimental techniques are distinct in testing mode (e.g., tensile, inflation tests), samples' species (human or animal), shape and condition (e.g., healthy, treated), preservation methods, setup and test protocol (e.g., preconditioning, strain rate). The meaningful results reported in the pertinent literature are discussed, analysing differences, key features and weaknesses of the methodologies adopted. In addition, numerical techniques based on the finite element method are reported, incorporating the essential steps for the development of corneal models, such as geometry, material characterization and boundary conditions, and their application in the research field to extend the experimental results by including further relevant aspects and in the clinical field for diagnostic procedure, treatment and planning surgery. This review aims to analyse the state-of-art of the bioengineering techniques developed over the years to study the corneal biomechanics, highlighting their potentiality to improve diagnosis, treatment and healing process of the corneal tissue, and, at the same, pointing out the current limits in the experimental equipment and numerical tools that are not able to fully characterize in vivo corneal tissues non-invasively and discourage the use of finite element models in daily clinical practice for surgical planning.
Identifiants
pubmed: 38598066
doi: 10.1007/s13246-024-01403-2
pii: 10.1007/s13246-024-01403-2
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : MIUR
ID : FISR2019_03221
Informations de copyright
© 2024. The Author(s).
Références
Kelly DJ, Farrell SM (2018) Physiology and role of intraocular pressure in contemporary anesthesia. Anesth Analg 126:1551–1562. https://doi.org/10.1213/ANE.0000000000002544
doi: 10.1213/ANE.0000000000002544
pubmed: 29049074
Dawson DG, Edelhauser HF (2011) Adler’s Physiology of the Eye: Expert Consult, 11th Edition, https://www.researchgate.net/publication/281572472
Bharathi RB, Poojary RG, Prabhu GK, Ve RS (2022) Finite element method for estimation of applanation force and to study the influence of intraocular pressure of eye on tonometry. Int Ophthalmol 42:1997–2005. https://doi.org/10.1007/s10792-021-02157-6
doi: 10.1007/s10792-021-02157-6
pubmed: 35665874
pmcid: 9287227
Hon Y, Chen GZ, Lu SH, Lam DCC, Lam AKC (2017) High myopes have lower normalised corneal tangent moduli (less ‘stiff’ corneas) than low myopes. Ophthalmic Physiol Opt 37:42–50. https://doi.org/10.1111/opo.12335
doi: 10.1111/opo.12335
pubmed: 27873338
Song Y, Wu D, Shen M, Wang L, Wang C, Cai Y, Xue C, Cheng GPM, Zheng Y, Wang Y (2022) Measuring human corneal stromal biomechanical properties using tensile testing combined with optical coherence tomography. Front Bioeng Biotechnol. https://doi.org/10.3389/fbioe.2022.882392
doi: 10.3389/fbioe.2022.882392
pubmed: 36704295
pmcid: 9808043
Zhao Y, Shen Y, Yan Z, Tian M, Zhao J, Zhou X (2019) Relationship among corneal stiffness, thickness, and biomechanical parameters measured by Corvis ST, Pentacam and ORA in Keratoconus. Front Physiol. https://doi.org/10.3389/fphys.2019.00740
doi: 10.3389/fphys.2019.00740
pubmed: 32038300
pmcid: 6930913
Vellara HR, Patel DV (2015) Biomechanical properties of the keratoconic cornea: a review. Clin Exp Optom 98:31–38. https://doi.org/10.1111/cxo.12211
doi: 10.1111/cxo.12211
pubmed: 25545947
Wu N, Chen Y, Yu X, Li M, Wen W, Sun X (2016) Changes in corneal biomechanical properties after long-term topical Prostaglandin therapy. PLOS ONE. https://doi.org/10.1371/journal.pone.0155527
doi: 10.1371/journal.pone.0155527
pubmed: 28036386
pmcid: 5201266
Satitpitakul V, Taweekitikul P, Puangsricharern V, Kasetsuwan N, Reinprayoon U, Kittipibul T (2021) Alteration of corneal biomechanical properties in patients with dry eye disease. PLOS ONE. https://doi.org/10.1371/journal.pone.0254442
doi: 10.1371/journal.pone.0254442
pubmed: 34252118
pmcid: 8274861
Xiang Y, Shen M, Xue C, Wu D, Wang Y (2018) Tensile biomechanical properties and constitutive parameters of human corneal stroma extracted by SMILE procedure. J Mech Behav Biomed Mater 85:102–108. https://doi.org/10.1016/j.jmbbm.2018.05.042
doi: 10.1016/j.jmbbm.2018.05.042
pubmed: 29879580
Elsheikh A, Alhasso D (2009) Mechanical anisotropy of porcine cornea and correlation with stromal microstructure. Exp Eye Res 88:1084–1091. https://doi.org/10.1016/j.exer.2009.01.010
doi: 10.1016/j.exer.2009.01.010
pubmed: 19450454
Zeng Y, Yang J, Huang K, Lee Z, Lee X (2001) A comparison of biomechanical properties between human and porcine cornea. J Biomech 34(4):533–537
doi: 10.1016/S0021-9290(00)00219-0
pubmed: 11266678
Elsheikh A, Alhasso D, Rama P (2008) Biomechanical properties of human and porcine corneas. Exp Eye Res 86:783–790. https://doi.org/10.1016/j.exer.2008.02.006
doi: 10.1016/j.exer.2008.02.006
pubmed: 18396276
Fontanella CG, Carniel EL, Corain L, Peruffo A, Iacopetti I, Pavan PG, Todros S, Perazzi A (2021) Mechanical behaviour of healthy versus alkali-lesioned corneas by a porcine organ culture model. BMC Vet Res. https://doi.org/10.1186/s12917-021-03050-1
doi: 10.1186/s12917-021-03050-1
pubmed: 34711207
pmcid: 8555156
Boschetti F, Triacca V, Spinelli L, Pandolfi A (2012) Mechanical characterization of porcine corneas. J Biomech Eng. https://doi.org/10.1115/1.4006089
doi: 10.1115/1.4006089
pubmed: 22482683
Su P, Yang Y, Xiao J, Song Y (2015) Corneal hyper-viscoelastic model: derivations, experiments, and simulations. Acta Bioeng Biomech 17:73–84. https://doi.org/10.5277/ABB-00142-2014-03
doi: 10.5277/ABB-00142-2014-03
pubmed: 26399307
Tonsomboon K, Koh CT, Oyen ML (2014) Time-dependent fracture toughness of cornea. J Mech Behav Biomed Mater 34:116–123. https://doi.org/10.1016/j.jmbbm.2014.01.015
doi: 10.1016/j.jmbbm.2014.01.015
pubmed: 24566382
Toniolo I, Mascolini MV, Neri S, Perazzi A, Fontanella CG (2023) Experimental analysis of the biomechanics of healthy porcine corneas. In: Patron Editore S.r.l., 2023. Convegno Nazionale di Bioingegneria2023 8th National Congress of Bioengineering, GNB 2023 Padova 21 June 2023 through 23 June 2023, Code 193282. scopus link: https://www.scopus.com/record/display.uri?eid=2-s2.0-85175876905&origin=resultslist
Nambiar MH, Liechti L, Müller F, Bernau W, Studer H, Roy AS, Seiler TG, Büchler P (2022) Orientation and depth dependent mechanical properties of the porcine cornea: Experiments and parameter identification. Exp Eye Res. https://doi.org/10.1016/j.exer.2022.109266
doi: 10.1016/j.exer.2022.109266
pubmed: 36179857
Elsheikh A, Kassem W, Jones SW, Jones S (2011) Strain-rate sensitivity of porcine and ovine corneas. https://www.researchgate.net/publication/51495138
Xue C, Xiang Y, Shen M, Wu D, Wang Y (2018) Preliminary investigation of the mechanical anisotropy of the normal human corneal stroma. J Ophthalmol. https://doi.org/10.1155/2018/5392041
doi: 10.1155/2018/5392041
pubmed: 30425855
pmcid: 6218724
Mahdian M, Seifzadeh A, Mokhtarian A, Doroodgar F (2021) Characterization of the transient mechanical properties of human cornea tissue using the tensile test simulation. Mater Today Commun. https://doi.org/10.1016/j.mtcomm.2021.102122
doi: 10.1016/j.mtcomm.2021.102122
Elsheikh A, Anderson K (2005) Comparative study of corneal strip extensometry and inflation tests. J R Soc Interface 2:177–185. https://doi.org/10.1098/rsif.2005.0034
doi: 10.1098/rsif.2005.0034
pubmed: 16849178
pmcid: 1629069
Ashofteh Yazdi A, Melchor J, Torres J, Faris I, Callejas A, Gonzalez-Andrades M, Rus G (2020) Characterization of non-linear mechanical behavior of the cornea. Sci Rep. https://doi.org/10.1038/s41598-020-68391-7
doi: 10.1038/s41598-020-68391-7
pubmed: 32665558
pmcid: 7360609
Arsalan Khan M, Elsheikh A, Ahmad Khan I (2018) Biomechanical behaviour - anisotropy of eye cornea through experimental strip tests. IOP Conf Ser Mater Sci Eng Inst Phys Publishing. https://doi.org/10.1088/1757-899X/310/1/012075
doi: 10.1088/1757-899X/310/1/012075
Du R, Tian H, Xu X, Shao Y, Song F (2017) Depth-dependent mechanical characteristics of porcine cornea. Soft Mater 15:27–33. https://doi.org/10.1080/1539445X.2016.1242497
doi: 10.1080/1539445X.2016.1242497
Lombardo G, Serrao S, Rosati M, Lombardo M (2014) Analysis of the viscoelastic properties of the human cornea using scheimpflug imaging in inflation experiment of eye globes. PLOS ONE. https://doi.org/10.1371/journal.pone.0112169
doi: 10.1371/journal.pone.0112169
pubmed: 25397674
pmcid: 4232387
Kling S, Marcos S (2013) Effect of hydration state and storage media on corneal biomechanical response from in vitro inflation tests. J Refract Surg 29:490–497. https://doi.org/10.3928/1081597X-20130617-08
doi: 10.3928/1081597X-20130617-08
pubmed: 23820232
Kohlhaas M, Spoerl E, Schilde T, Unger G, Wittig C, Pillunat LE (2006) Biomechanical evidence of the distribution of cross-links in corneastreated with riboflavin and ultraviolet a light. J Cataract Refract Surg 32:279–283. https://doi.org/10.1016/j.jcrs.2005.12.092
doi: 10.1016/j.jcrs.2005.12.092
pubmed: 16565005
Wollensak G, Spoerl E, Seiler T (2003) Stress-strain measurements of human and porcine corneas after riboflavin-ultraviolet-A-induced cross-linking. J Cataract Refract Surg 29:1780–1785. https://doi.org/10.1016/S0886-3350(03)00407-3
doi: 10.1016/S0886-3350(03)00407-3
pubmed: 14522301
Matteoli S, Virga A, Paladini I, Mencucci R, Corvi A (2016) Investigation into the elastic properties of ex vivo porcine corneas subjected to inflation test after cross-linking treatment. J Appl Biomater Funct Mater 14:e163–e170. https://doi.org/10.5301/jabfm.5000262
doi: 10.5301/jabfm.5000262
pubmed: 26952586
Bao F, Jiang L, Wang X, Zhang D, Wang Q, Zeng Y (2012) Assessment of the ex vivo biomechanical properties of porcine cornea with inflation test for corneal xenotransplantation. J Med Eng Technol 36:17–21. https://doi.org/10.3109/03091902.2011.629276
doi: 10.3109/03091902.2011.629276
pubmed: 22085017
Kling S, Marcos S (2013) Contributing factors to corneal deformation in air puff measurements. Invest Ophthalmol Vis Sci 54:5078–5085. https://doi.org/10.1167/iovs.13-12509
doi: 10.1167/iovs.13-12509
pubmed: 23821200
Nohava J, Swain M, Lang SJ, Maier P, Heinzelmann S, Reinhard T, Eberwein P (2018) Instrumented indentation for determination of mechanical properties of human cornea after ultraviolet-A crosslinking. J Biomed Mater Res A 106:1413–1420. https://doi.org/10.1002/jbm.a.36337
doi: 10.1002/jbm.a.36337
pubmed: 29318768
Mascolini MV, Fontanella CG, Berardo A, Carniel EL (2023) Influence of transurethral catheters on urine pressure-flow relationships in males: a computational fluid-dynamics study. Comput Methods Programs Biomed. https://doi.org/10.1016/j.cmpb.2023.107594
doi: 10.1016/j.cmpb.2023.107594
pubmed: 37207463
Caragiuli M, Mandolini M, Landi D, Bruno G, De Stefani A, Gracco A, Toniolo I (2021) A finite element analysis for evaluating mandibular advancement devices. J Biomech. https://doi.org/10.1016/j.jbiomech.2021.110298
doi: 10.1016/j.jbiomech.2021.110298
pubmed: 33639337
Toniolo I, Berardo A, Foletto M, Fiorillo C, Quero G, Perretta S, Carniel EL (2022) Patient-specific stomach biomechanics before and after laparoscopic sleeve gastrectomy. Surg Endosc 36:7998–8011. https://doi.org/10.1007/s00464-022-09233-7
doi: 10.1007/s00464-022-09233-7
pubmed: 35451669
pmcid: 9028903
Chen J, Xu Y, Li C, Zhang L, Yi F, Lu Y (2021) Displacement and stress distribution of the craniomaxillofacial complex under different surgical conditions: a three-dimensional finite element analysis of fracture mechanics. BMC Oral Health. https://doi.org/10.1186/s12903-021-01941-1
doi: 10.1186/s12903-021-01941-1
pubmed: 34972503
pmcid: 8720213
Eltes PE, Bartos M, Hajnal B, Pokorni AJ, Kiss L, Lacroix D, Varga PP, Lazary A (2021) Development of a computer-aided design and finite element analysis combined method for affordable spine surgical navigation with 3D-printed customized template. Front Surg. https://doi.org/10.3389/fsurg.2020.583386
doi: 10.3389/fsurg.2020.583386
pubmed: 35071306
pmcid: 8192795
Whitford C, Movchan NV, Studer H, Elsheikh A (2018) A viscoelastic anisotropic hyperelastic constitutive model of the human cornea. Biomech Model Mechanobiol 17:19–29. https://doi.org/10.1007/s10237-017-0942-2
doi: 10.1007/s10237-017-0942-2
pubmed: 28780705
de Oteyza GG, de Toledo JÁ, Barraquer RI, Kling S (2021) Refractive changes of a new asymmetric intracorneal ring segment with variable thickness and base width: a 2D finite-element model. PLOS ONE. https://doi.org/10.1371/journal.pone.0257222
doi: 10.1371/journal.pone.0257222
pubmed: 34506616
pmcid: 8432772
Carniel EL, Toniolo I, Fontanella CG (2020) Computational biomechanics: In-silico tools for the investigation of surgical procedures and devices. Bioengineering 7:1–12. https://doi.org/10.3390/bioengineering7020048
doi: 10.3390/bioengineering7020048
Zhang D, Qin X, Zhang H, Li L (2021) Time-varying regularity of changes in biomechanical properties of the corneas after removal of anterior corneal tissue. Biomed Eng Online. https://doi.org/10.1186/s12938-021-00948-7
doi: 10.1186/s12938-021-00948-7
pubmed: 34920735
pmcid: 8684265
Zhang H, Zhang D, Qin X, Wang H, Li L (2018) Study of the transversal deformation of corneal strip under uniaxial loading. J Mech Med Biol. https://doi.org/10.1142/S0219519418400183
doi: 10.1142/S0219519418400183
Wang X, Li X, Chen W, He R, Gao Z, Feng P (2017) Effects of ablation depth and repair time on the corneal elastic modulus after laser in situ keratomileusis. Biomed Eng Online. https://doi.org/10.1186/s12938-017-0311-5
doi: 10.1186/s12938-017-0311-5
pubmed: 29157240
pmcid: 5697161
Zheng Y, Xue C, Wang J, Chen X, Wang X, Wang Y (2023) Analysis of the correlation between biomechanical properties and corneal densitometry in myopic eyes. Front Bioeng Biotechnol. https://doi.org/10.3389/fbioe.2023.1182372
doi: 10.3389/fbioe.2023.1182372
pubmed: 38288243
pmcid: 10758493
Ko MWL, Leung LKK, Lam DCC, Leung CKS (2013) Characterization of corneal tangent modulus in vivo. Acta Ophthalmol. https://doi.org/10.1111/aos.12066
doi: 10.1111/aos.12066
pubmed: 23336962
Dorronsoro C, Pascual D, Pérez-Merino P, Kling S, Marcos S (1980) Optical coherence tomography; (170.3880) Medical and biological imaging. www.vision.csic.es
Hatami-Marbini H, Etebu E (2013) An experimental and theoretical analysis of unconfined compression of corneal stroma. J Biomech 46:1752–1758. https://doi.org/10.1016/j.jbiomech.2013.03.013
doi: 10.1016/j.jbiomech.2013.03.013
pubmed: 23664313
Hatami-Marbini H, Etebu E (2013) Rate dependent biomechanical properties of corneal stroma in unconfined compression. Biorheology 50:133–147. https://doi.org/10.3233/BIR-130634
doi: 10.3233/BIR-130634
pubmed: 23863279
Whitford C, Joda A, Jones S, Bao F, Rama P, Elsheikh A (2016) Ex vivo testing of intact eye globes under inflation conditions to determine regional variation of mechanical stiffness. Eye Vis. https://doi.org/10.1186/s40662-016-0052-8
doi: 10.1186/s40662-016-0052-8
Hatami-Marbini H (2014) Viscoelastic shear properties of the corneal stroma. J Biomech 47:723–728. https://doi.org/10.1016/j.jbiomech.2013.11.019
doi: 10.1016/j.jbiomech.2013.11.019
pubmed: 24368145
Kling S, Hafezi F (2017) Corneal biomechanics – a review. Ophthalmic Physiol Opt 37:240–252. https://doi.org/10.1111/opo.12345
doi: 10.1111/opo.12345
pubmed: 28125860
Wang JJ, Liu XY, Bao FJ, Lopes BT, Wang LZ, Eliasy A, Abass A, Elsheikh A (2021) Review of ex-vivo characterisation of corneal biomechanics. Med Nov Technol Devices. https://doi.org/10.1016/j.medntd.2021.100074
doi: 10.1016/j.medntd.2021.100074
Wang L, Tian L, Huang Y, Huang Y, Zheng Y (2018) Assessment of corneal Biomechanical properties with inflation test using Optical Coherence Tomography. Ann Biomed Eng 46:247–256. https://doi.org/10.1007/s10439-017-1973-7
doi: 10.1007/s10439-017-1973-7
pubmed: 29297099
Anderson K, El-Sheikh A, Newson T (2004) Application of structural analysis to the mechanical behaviour of the cornea. J R Soc Interface 1:3–15. https://doi.org/10.1098/rsif.2004.0002
doi: 10.1098/rsif.2004.0002
pubmed: 16849148
pmcid: 1618927
Chong J, Dupps WJ (2021) Corneal biomechanics: measurement and structural correlations. Exp Eye Res. https://doi.org/10.1016/j.exer.2021.108508
doi: 10.1016/j.exer.2021.108508
pubmed: 33609511
pmcid: 8046161
Ambrósio R, Ramos I, Luz A, Faria FC, Steinmueller A, Krug M, Belin MW, Roberts CJ (2013) Dynamic ultra high speed Scheimpflug imaging for assessing corneal biomechanical properties. Revista Brasileira de Oftalmologia 72:99–102
doi: 10.1590/S0034-72802013000200005
Luce DA (2005) Determining in vivo biomechanical properties of the cornea with an ocular response analyzer. J Cataract Refract Surg 31:156–162. https://doi.org/10.1016/j.jcrs.2004.10.044
doi: 10.1016/j.jcrs.2004.10.044
pubmed: 15721708
Qin X, Tian L, Zhang H, Chen X, Li L (2019) Evaluation of corneal elastic modulus based on corneal visualization scheimpflug technology. Biomed Eng Online. https://doi.org/10.1186/s12938-019-0662-1
doi: 10.1186/s12938-019-0662-1
pubmed: 31870380
pmcid: 6929473
Zhang D, Zhang H, Tian L, Zheng Y, Fu C, Zhai C, Li L (2021) Exploring the biomechanical properties of the human cornea in vivo based on corvis ST. Front Bioeng Biotechnol. https://doi.org/10.3389/fbioe.2021.771763
doi: 10.3389/fbioe.2021.771763
pubmed: 35600111
pmcid: 8758580
Koprowski R (2019) Air Puff Tonometers: Challenges and insights, 2019, Patron. Iop Publishing Ltd
Wang B, Yang L, Cheng J, Wang J, Mei Y (2023) In-vivo high-speed biomechanical imaging of the cornea using corvis ST and digital image correlation. Comput Biol Med. https://doi.org/10.1016/j.compbiomed.2023.106540
doi: 10.1016/j.compbiomed.2023.106540
pubmed: 38199208
pmcid: 10311359
Eliasy A, Chen K-J, Vinciguerra R, Lopes BT, Abass A, Vinciguerra P, Ambrósio R Jr., Roberts CJ, Elsheikh A (2019) Determination of corneal biomechanical behavior in-vivo for healthy eyes using corvis ST tonometry: stress-strain index. Front Bioeng Biotechnol. https://doi.org/10.3389/fbioe.2019.00105
doi: 10.3389/fbioe.2019.00105
pubmed: 31157217
pmcid: 6532432
Padmanabhan P, Lopes BT, Eliasy A, Abass A, Elsheikh A (2022) Vivo Biomechanical Changes Associated with Keratoconus Progression. Curr Eye Res 47:982–986. https://doi.org/10.1080/02713683.2022.2058020
doi: 10.1080/02713683.2022.2058020
pubmed: 35385372
Yun SH, Chernyak D (2018) Brillouin microscopy: assessing ocular tissue biomechanics. Curr Opin Ophthalmol 29:299–305. https://doi.org/10.1097/ICU.0000000000000489
doi: 10.1097/ICU.0000000000000489
pubmed: 29771749
pmcid: 6012042
Scarcelli G, Yun SH (2012) In vivo Brillouin optical microscopy of the human eye. Opt Express 20(8):9197–202
doi: 10.1364/OE.20.009197
pubmed: 22513631
pmcid: 3500092
Lam AKC, Hon Y, Leung LKK, Lam DCC (2015) Repeatability of a novel corneal indentation device for corneal biomechanical measurement. Ophthalmic Physiol Opt 35:455–461. https://doi.org/10.1111/opo.12219
doi: 10.1111/opo.12219
pubmed: 26094834
Shih PJ, Cao HJ, Huang CJ, Wang IJ, Shih WP, Yen JY (2015) A corneal elastic dynamic model derived from Scheimpflug imaging technology. Ophthalmic Physiol Opt 35:663–672. https://doi.org/10.1111/opo.12240
doi: 10.1111/opo.12240
pubmed: 26353939
Sit AJ, Lin SC, Kazemi A, McLaren JW, Pruet CM, Zhang X (2017) In vivo noninvasive measurement of young’s modulus of elasticity in human eyes: a feasibility study. J Glaucoma 26:967–973. https://doi.org/10.1097/IJG.0000000000000774
doi: 10.1097/IJG.0000000000000774
pubmed: 28858155
pmcid: 5669996
Ramier A, Eltony AM, Chen YT, Clouser F, Birkenfeld JS, Watts A, Yun SH (2020) In vivo measurement of shear modulus of the human cornea using optical coherence elastography. Sci Rep. https://doi.org/10.1038/s41598-020-74383-4
doi: 10.1038/s41598-020-74383-4
pubmed: 33060714
pmcid: 7567833
Esporcatte LPG, Salomão MQ, Lopes BT, Vinciguerra P, Vinciguerra R, Roberts C, Elsheikh A, Dawson DG, Ambrósio R (2020) Biomechanical diagnostics of the cornea. Eye Vis. https://doi.org/10.1186/s40662-020-0174-x
doi: 10.1186/s40662-020-0174-x
De Stefano VS, Dupps WJ (2017) Biomechanical Diagnostics of the Cornea. http://journals.lww.com/internat-ophthalmology
Shih PJ, Wang IJ, Cai WF, Yen JY (2017) Biomechanical simulation of stress concentration and intraocular pressure in corneas subjected to myopic refractive surgical procedures. Sci Rep. https://doi.org/10.1038/s41598-017-14293-0
doi: 10.1038/s41598-017-14293-0
pubmed: 29234076
pmcid: 5727262
Ariza-Gracia M, Zurita JF, Piñero DP, Rodriguez-Matas JF, Calvo B (2015) Coupled biomechanical response of the cornea assessed by non-contact tonometry. A simulation study. PLOS ONE. https://doi.org/10.1371/journal.pone.0121486
doi: 10.1371/journal.pone.0121486
pubmed: 25780915
pmcid: 4364121
Baek JW, Park SJ (2019) Finite element analysis of cornea deformation and curvature change during the keratoplasty suturing process. Biomed Eng Lett 9:203–209. https://doi.org/10.1007/s13534-019-00100-4
doi: 10.1007/s13534-019-00100-4
pubmed: 31168425
pmcid: 6520425
Karimi A, Meimani N, Razaghi R, Rahmati SM, Jadidi K, Rostami M (2019) Biomechanics of the healthy and Keratoconic Corneas: a combination of the Clinical Data, Finite element analysis, and Artificial neural network. Curr Pharm Des 24:4474–4483. https://doi.org/10.2174/1381612825666181224123939
doi: 10.2174/1381612825666181224123939
Zhou B, Sit AJ, Zhang X (2017) Noninvasive measurement of wave speed of porcine cornea in ex vivo porcine eyes for various intraocular pressures. Ultrasonics 81:86–92. https://doi.org/10.1016/j.ultras.2017.06.008
doi: 10.1016/j.ultras.2017.06.008
pubmed: 28618301
pmcid: 5541902
Kobayashi A, Izaki R, Fujita H, Harada K, Ozaki H, Kadonosono K, Uchio E (2023) Finite element analysis of changes in tensile strain and deformation by airbag impact in eyes of various axial lengths. Int Ophthalmol 43:2143–2151. https://doi.org/10.1007/s10792-022-02609-7
doi: 10.1007/s10792-022-02609-7
pubmed: 36536199
Fang L, Wang Y, Yang R, Deng S, Deng J, Wan L (2020) Effects of the LASIK flap thickness on corneal biomechanical behavior: a finite element analysis. BMC Ophthalmol. https://doi.org/10.1186/s12886-020-01338-8
doi: 10.1186/s12886-020-01338-8
pubmed: 32811461
pmcid: 7437040
Bagheri NM, Kadkhodaei M, Pirhadi S, Mosaddegh P (2021) Effects of intracorneal ring segments implementation technique and design on corneal biomechanics and keratometry in a personalized computational analysis. Sci Rep. https://doi.org/10.1038/s41598-021-93821-5
doi: 10.1038/s41598-021-93821-5
pubmed: 34934149
pmcid: 8692621
Wang S, Chester SA (2021) Multi-physics modeling and finite element formulation of corneal UV cross-linking. Biomech Model Mechanobiol 20:1561–1578. https://doi.org/10.1007/s10237-021-01463-3
doi: 10.1007/s10237-021-01463-3
pubmed: 34009489
Asejczyk-Widlicka M, Srodka W (2020) Finite element simulation of Goldmann tonometry after refractive surgery. Clin Biomech Elsevier Ltd 71:24–28. https://doi.org/10.1016/j.clinbiomech.2019.09.007
doi: 10.1016/j.clinbiomech.2019.09.007
Lago MA, Rupérez MJ, Martínez-Martínez F, Monserrat C, Larra E, Güell JL, Peris-Martínez C (2015) A new methodology for the in vivo estimation of the elastic constants that characterize the patient-specific biomechanical behavior of the human cornea. J Biomech 48:38–43. https://doi.org/10.1016/j.jbiomech.2014.11.009
doi: 10.1016/j.jbiomech.2014.11.009
pubmed: 25465193
Sinha Roy A, Kurian M, Matalia H, Shetty R (2015) Air-puff associated quantification of non-linear biomechanical properties of the human cornea in vivo. J Mech Behav Biomed Mater 48:173–182. https://doi.org/10.1016/j.jmbbm.2015.04.010
doi: 10.1016/j.jmbbm.2015.04.010
pubmed: 25955559
Qin X, Tian L, Zhang H, Zhang D, Jie Y, Zhang HX, Li L (2022) Determine corneal biomechanical parameters by finite element simulation and parametric analysis based on ORA measurements. Front Bioeng Biotechnol. https://doi.org/10.3389/fbioe.2022.862947
doi: 10.3389/fbioe.2022.862947
pubmed: 36704309
pmcid: 9800839
Shih PJ, Huang CJ, Huang TH, Lin HC, Yen JY, Wang IJ, Cao HJ, Shih WP, Dai CA (2017) Estimation of the corneal young’s modulus in vivo based on a fluid-filled spherical-shell model with scheimpflug imaging. J Ophthalmol. https://doi.org/10.1155/2017/5410143
doi: 10.1155/2017/5410143
pubmed: 29250440
pmcid: 5698833
Salmaso C, Toniolo I, Fontanella CG, Da Roit P, Albanese A, Polese L, Stefanini C, Foletto M, Carniel EL (2020) Computational tools for the Reliability Assessment and the Engineering Design of procedures and devices in bariatric surgery. Ann Biomed Eng 48:2466–2483. https://doi.org/10.1007/s10439-020-02542-9
doi: 10.1007/s10439-020-02542-9
pubmed: 32472365
Toniolo I, Fontanella CG, Foletto M, Carniel EL (2022) Coupled experimental and computational approach to stomach biomechanics: Towards a validated characterization of gastric tissues mechanical properties. J Mech Behav Biomed Mater. https://doi.org/10.1016/j.jmbbm.2021.104914
doi: 10.1016/j.jmbbm.2021.104914
pubmed: 34715641