Association between arterial oxygen and mortality across critically ill patients with hematologic malignancies: results from an international collaborative network.

Hematological malignancy Hyperoxemia Hyperoxia Mechanical ventilation Mortality

Journal

Intensive care medicine
ISSN: 1432-1238
Titre abrégé: Intensive Care Med
Pays: United States
ID NLM: 7704851

Informations de publication

Date de publication:
10 Apr 2024
Historique:
received: 02 12 2023
accepted: 09 03 2024
medline: 10 4 2024
pubmed: 10 4 2024
entrez: 10 4 2024
Statut: aheadofprint

Résumé

Patients with hematological malignancies are at high risk for life-threatening complications. To date, little attention has been paid to the impact of hyperoxemia and excess oxygen use on mortality. The aim of this study was to investigate the association between partial pressure of arterial oxygen (PaO Data from three international cohorts (Europe, Canada, Oceania) of patients who received respiratory support (noninvasive ventilation, high-flow nasal cannula, invasive mechanical ventilation) were obtained. We used mixed-effect Cox models to investigate the association between day one PaO 11,249 patients were included. On day one, 5716 patients (50.8%) had normoxemia (60 ≤ PaO In critically-ill patients with hematological malignancies, exposure to hyperoxemia and excess oxygen use were associated with increased mortality, with variable magnitude across subgroups. This might be a modifiable factor to improve mortality.

Identifiants

DOI: 10.1007/s00134-024-07389-5 PMID: 38598124
pubmed: 38598124
doi: 10.1007/s00134-024-07389-5
pii: 10.1007/s00134-024-07389-5
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Investigateurs

Laurent Argaud (L)
François Barbier (F)
Dominique Benoit (D)
Naike Bigé (N)
Fabrice Bruneel (F)
Emmanuel Canet (E)
Yves Cohen (Y)
Michael Darmon (M)
Didier Gruson (D)
Kada Klouche (K)
Loay Kontar (L)
Alexandre Lautrette (A)
Christine Lebert (C)
Guillaume Louis (G)
Julien Mayaux (J)
Anne-Pascale Meert (AP)
Anne-Sophie Moreau (AS)
Martine Nyunga (M)
Vincent Peigne (V)
Pierre Perez (P)
Jean-Herlé Raphalen (JH)
Carole Schwebel (C)
Jean-Marie Tonnelier (JM)
Florent Wallet (F)
Lara Zafrani (L)
Bram Rochwerg (B)
Farah Shoukat (F)
Dean Fergusson (D)
Bruno Ferreyro (B)
Paul Heffernan (P)
Margaret Herridge (M)
Sheldon Magder (S)
Mark Minden (M)
Rakesh Patel (R)
Salman Qureshi (S)
Aaron Schimmer (A)
Santhosh Thyagu (S)
Han Ting Wang (HT)
Sangeeta Mehta (S)
Sean M Bagshaw (SM)

Informations de copyright

© 2024. Crown.

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Auteurs

Guillaume Dumas (G)

Interdepartmental Division of Critical Care Medicine, Sinai Health System/University Health Network, University of Toronto, Toronto, Canada.
Department of Medicine, Sinai Health System and University Health Network, Toronto, Canada.
Service de Médecine Intensive-Réanimation, CHU Grenoble-Alpes, Université Grenoble-Alpes, INSERM U1042-HP2, Grenoble, France.
ORCID: 0000-0002-7034-7195

Idunn S Morris (IS)

Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, Canada.
Department of Medicine, Division of Respirology, University Health Network, Toronto, Canada.
Department of Physiology, University of Toronto, Toronto, Canada.
Department of Intensive Care Medicine, Nepean Hospital, Kingswood, NSW, Australia.

Tamishta Hensman (T)

Austin Health, Heidelberg, VIC, Australia.
Guys and St, Thomas' NHS Foundation Trust, London, UK.

Sean M Bagshaw (SM)

Department of Critical Care Medicine, Faculty of Medicine and Dentistry, University of Alberta and Alberta Health Services, Edmonton, Canada.

Alexandre Demoule (A)

Service de Médecine Intensive Et Réanimation (Département R3S), Sorbonne Université, INSERM, UMRS1158 Neurophysiologie Respiratoire Expérimentale et Clinique, AP-HP, Groupe Hospitalier Universitaire APHP-Sorbonne Université, Site Pitié-Salpêtrière, 75013, Paris, France.

Bruno L Ferreyro (BL)

Interdepartmental Division of Critical Care Medicine, Sinai Health System/University Health Network, University of Toronto, Toronto, Canada.
Department of Medicine, Sinai Health System and University Health Network, Toronto, Canada.

Achille Kouatchet (A)

Medical Intensive Care Unit, Angers Teaching Hospital, Angers, France.

Virginie Lemiale (V)

Medical Intensive Care Unit, Saint-Louis Teaching Hospital, AP-HP, Paris, France.
ECSTRA Team, Biostatistics and Clinical Epidemiology, UMR 1153 (Center of Epidemiology and Biostatistics Sorbonne Paris Cité, CRESS), INSERM, Université de Paris, Paris, France.

Djamel Mokart (D)

Intensive Care Unit, Institut Paoli Calmettes, Marseille, France.

Frédéric Pène (F)

Medical Intensive Care Unit, Cochin Hospital, Hôpitaux Universitaires Paris Centre, AP-HP, Paris, France.
Institut Cochin, INSERM Unité, 1016/Centre National de la Recherche Scientifique (CNRS) UnitéMixte de Recherche (UMR) 8104/Université Paris Cité, Paris, France.

Sangeeta Mehta (S)

Interdepartmental Division of Critical Care Medicine, Sinai Health System/University Health Network, University of Toronto, Toronto, Canada.
Department of Medicine, Sinai Health System and University Health Network, Toronto, Canada.

Elie Azoulay (E)

Medical Intensive Care Unit, Saint-Louis Teaching Hospital, AP-HP, Paris, France.
ECSTRA Team, Biostatistics and Clinical Epidemiology, UMR 1153 (Center of Epidemiology and Biostatistics Sorbonne Paris Cité, CRESS), INSERM, Université de Paris, Paris, France.

Laveena Munshi (L)

Interdepartmental Division of Critical Care Medicine, Sinai Health System/University Health Network, University of Toronto, Toronto, Canada. Laveena.munshi@sinaihealth.ca.
Department of Medicine, Sinai Health System and University Health Network, Toronto, Canada. Laveena.munshi@sinaihealth.ca.
18-206 Mount Sinai Hospital, 600 University Avenue, Toronto, ON, M5G 1X5, Canada. Laveena.munshi@sinaihealth.ca.

Classifications MeSH