Potentiating Activity of GmhA Inhibitors on Gram-Negative Bacteria.

Journal

Journal of medicinal chemistry
ISSN: 1520-4804
Titre abrégé: J Med Chem
Pays: United States
ID NLM: 9716531

Informations de publication

Date de publication:
10 Apr 2024
Historique:
medline: 10 4 2024
pubmed: 10 4 2024
entrez: 10 4 2024
Statut: aheadofprint

Résumé

Inhibition of the biosynthesis of bacterial heptoses opens novel perspectives for antimicrobial therapies. The enzyme GmhA responsible for the first committed biosynthetic step catalyzes the conversion of sedoheptulose 7-phosphate into d-

Identifiants

DOI: 10.1021/acs.jmedchem.4c00037 PMID: 38598312
pubmed: 38598312
doi: 10.1021/acs.jmedchem.4c00037
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Auteurs

François Moreau (F)

Mutabilis, 102 Avenue Gaston Roussel, Romainville 93230, France.

Dmytro Atamanyuk (D)

Mutabilis, 102 Avenue Gaston Roussel, Romainville 93230, France.

Markus Blaukopf (M)

Department of Chemistry, University of Natural Resources and Life Sciences, Muthgasse 18, Vienna A-1190, Austria.

Marek Barath (M)

Department of Chemistry, University of Natural Resources and Life Sciences, Muthgasse 18, Vienna A-1190, Austria.
Institute of Chemistry, Center for Glycomics, Slovak Academy of Sciences, Dúbravská cesta 9, Bratislava SK-845 38, Slovakia.

Mihály Herczeg (M)

Department of Chemistry, University of Natural Resources and Life Sciences, Muthgasse 18, Vienna A-1190, Austria.
Department of Pharmaceutical Chemistry, University of Debrecen, Debrecen 4032, Hungary.
ORCID: 0000-0002-7938-9789

Nuno M Xavier (NM)

Department of Chemistry, University of Natural Resources and Life Sciences, Muthgasse 18, Vienna A-1190, Austria.
Centro de Química Estrutural, Institute of Molecular Sciences, Faculdade de Ciências, Universidade de Lisboa, Ed. C8, 5° Piso, Campo Grande, Lisboa 1749-016, Portugal.
ORCID: 0000-0001-8739-8768

Jérôme Monbrun (J)

Activation, 10 Rue Jacquard, Chassieu 69680, France.

Etienne Airiau (E)

Activation, 10 Rue Jacquard, Chassieu 69680, France.

Vivien Henryon (V)

Activation, 10 Rue Jacquard, Chassieu 69680, France.

Frédéric Leroy (F)

Carbosynth Limited, 8&9 Old Station Business Park, Compton, Berkshire RG20 6NE, U.K.

Stéphanie Floquet (S)

Mutabilis, 102 Avenue Gaston Roussel, Romainville 93230, France.

Damien Bonnard (D)

Mutabilis, 102 Avenue Gaston Roussel, Romainville 93230, France.

Robert Szabla (R)

Department of Biochemistry, University of Western Ontario, London, ON N6A 3K7, Canada.

Chris Brown (C)

Department of Biochemistry, University of Western Ontario, London, ON N6A 3K7, Canada.

Murray S Junop (MS)

Department of Biochemistry, University of Western Ontario, London, ON N6A 3K7, Canada.
ORCID: 0000-0001-6676-5717

Paul Kosma (P)

Department of Chemistry, University of Natural Resources and Life Sciences, Muthgasse 18, Vienna A-1190, Austria.
ORCID: 0000-0001-5342-7161

Vincent Gerusz (V)

Mutabilis, 102 Avenue Gaston Roussel, Romainville 93230, France.

Classifications MeSH