A subgroup of light-driven sodium pumps with an additional Schiff base counterion.


Journal

Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555

Informations de publication

Date de publication:
10 Apr 2024
Historique:
received: 12 10 2023
accepted: 01 04 2024
medline: 11 4 2024
pubmed: 11 4 2024
entrez: 10 4 2024
Statut: epublish

Résumé

Light-driven sodium pumps (NaRs) are unique ion-transporting microbial rhodopsins. The major group of NaRs is characterized by an NDQ motif and has two aspartic acid residues in the central region essential for sodium transport. Here we identify a subgroup of the NDQ rhodopsins bearing an additional glutamic acid residue in the close vicinity to the retinal Schiff base. We thoroughly characterize a member of this subgroup, namely the protein ErNaR from Erythrobacter sp. HL-111 and show that the additional glutamic acid results in almost complete loss of pH sensitivity for sodium-pumping activity, which is in contrast to previously studied NaRs. ErNaR is capable of transporting sodium efficiently even at acidic pH levels. X-ray crystallography and single particle cryo-electron microscopy reveal that the additional glutamic acid residue mediates the connection between the other two Schiff base counterions and strongly interacts with the aspartic acid of the characteristic NDQ motif. Hence, it reduces its pKa. Our findings shed light on a subgroup of NaRs and might serve as a basis for their rational optimization for optogenetics.

Identifiants

pubmed: 38600129
doi: 10.1038/s41467-024-47469-0
pii: 10.1038/s41467-024-47469-0
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

3119

Subventions

Organisme : EC | EU Framework Programme for Research and Innovation H2020 | H2020 Priority Excellent Science | H2020 Marie Skłodowska-Curie Actions (H2020 Excellent Science - Marie Skłodowska-Curie Actions)
ID : 847543

Informations de copyright

© 2024. The Author(s).

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Auteurs

E Podoliak (E)

Department of Ophthalmology, University Hospital Bonn, Medical Faculty, Bonn, Germany.

G H U Lamm (GHU)

Institute of Physical and Theoretical Chemistry, Goethe University Frankfurt, 60438, Frankfurt am Main, Germany.

E Marin (E)

Groningen Institute for Biomolecular Sciences and Biotechnology, University of Groningen, 9747AG, Groningen, the Netherlands.

A V Schellbach (AV)

Institute of Physical and Theoretical Chemistry, Goethe University Frankfurt, 60438, Frankfurt am Main, Germany.
School of Chemistry, University of Edinburgh, Edinburgh, EH9 3FJ, UK.

D A Fedotov (DA)

Fritz Haber Center for Molecular Dynamics Research, Institute of Chemistry, The Hebrew University of Jerusalem, Jerusalem, 9190401, Israel.

A Stetsenko (A)

Groningen Institute for Biomolecular Sciences and Biotechnology, University of Groningen, 9747AG, Groningen, the Netherlands.

M Asido (M)

Institute of Physical and Theoretical Chemistry, Goethe University Frankfurt, 60438, Frankfurt am Main, Germany.

N Maliar (N)

Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge, CB2 1GA, UK.

G Bourenkov (G)

European Molecular Biology Laboratory, EMBL Hamburg c/o DESY, 22607, Hamburg, Germany.

T Balandin (T)

Institute of Biological Information Processing (IBI-7: Structural Biochemistry), Forschungszentrum Jülich, Jülich, Germany.
JuStruct: Jülich Center for Structural Biology, Forschungszentrum Jülich, Jülich, Germany.

C Baeken (C)

Institute of Biological Information Processing (IBI-7: Structural Biochemistry), Forschungszentrum Jülich, Jülich, Germany.
JuStruct: Jülich Center for Structural Biology, Forschungszentrum Jülich, Jülich, Germany.

R Astashkin (R)

Univ. Grenoble Alpes, CEA, CNRS, Institut de Biologie Structurale (IBS), 38000, Grenoble, France.

T R Schneider (TR)

European Molecular Biology Laboratory, EMBL Hamburg c/o DESY, 22607, Hamburg, Germany.

A Bateman (A)

European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, UK.

J Wachtveitl (J)

Institute of Physical and Theoretical Chemistry, Goethe University Frankfurt, 60438, Frankfurt am Main, Germany.

I Schapiro (I)

Fritz Haber Center for Molecular Dynamics Research, Institute of Chemistry, The Hebrew University of Jerusalem, Jerusalem, 9190401, Israel.

V Busskamp (V)

Department of Ophthalmology, University Hospital Bonn, Medical Faculty, Bonn, Germany.

A Guskov (A)

Groningen Institute for Biomolecular Sciences and Biotechnology, University of Groningen, 9747AG, Groningen, the Netherlands.

V Gordeliy (V)

Institute of Biological Information Processing (IBI-7: Structural Biochemistry), Forschungszentrum Jülich, Jülich, Germany.
JuStruct: Jülich Center for Structural Biology, Forschungszentrum Jülich, Jülich, Germany.
Univ. Grenoble Alpes, CEA, CNRS, Institut de Biologie Structurale (IBS), 38000, Grenoble, France.

A Alekseev (A)

University Medical Center Göttingen, Institute for Auditory Neuroscience and InnerEarLab, Robert-Koch-Str. 40, 37075, Göttingen, Germany. alexey.alekseev@med.uni-goettingen.de.
Cluster of Excellence "Multiscale Bioimaging: from Molecular Machines to Networks of Excitable Cells" (MBExC), University of Göttingen, Göttingen, Germany. alexey.alekseev@med.uni-goettingen.de.

K Kovalev (K)

European Molecular Biology Laboratory, EMBL Hamburg c/o DESY, 22607, Hamburg, Germany. kirill.kovalev@embl-hamburg.de.

Classifications MeSH