Unveiling potent Schiff base derivatives with selective xanthine oxidase inhibition:

Gout In silico approach Schiff base Triazole Xanthine oxidase inhibition

Journal

Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society
ISSN: 1319-0164
Titre abrégé: Saudi Pharm J
Pays: Saudi Arabia
ID NLM: 9705695

Informations de publication

Date de publication:
May 2024
Historique:
received: 24 02 2024
accepted: 02 04 2024
medline: 11 4 2024
pubmed: 11 4 2024
entrez: 11 4 2024
Statut: ppublish

Résumé

This research describes the synthesis by an environmentally-friendly method, microwave irradiation, development and analysis of three novel and one previously identified Schiff base derivative as a potential inhibitor of bovine xanthine oxidase (BXO), a key enzyme implicated in the progression of gout. Meticulous experimentation revealed that these compounds (

Identifiants

DOI: 10.1016/j.jsps.2024.102062 PMID: 38601975 PMC: PMC11004395
pubmed: 38601975
doi: 10.1016/j.jsps.2024.102062
pii: S1319-0164(24)00112-9
pmc: PMC11004395
doi:

Types de publication

Journal Article

Langues

eng

Pagination

102062

Informations de copyright

© 2024 The Author(s).

Déclaration de conflit d'intérêts

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Auteurs

Fatna Bellahcene (F)

Laboratory of Fundamental Sciences, Faculty of Sciences, University of Amar Telidji, Laghouat, Algeria.

Khedidja Benarous (K)

Laboratory of Fundamental Sciences, Faculty of Sciences, University of Amar Telidji, Laghouat, Algeria.

Arif Mermer (A)

Department of Biotechnology, University of Health Sciences, İstanbul, Turkey.
Experimental Medicine Application and Research Center, Validebag Research Park, University of Health Sciences, İstanbul, Turkey.
Department of Pharmacy, University of Health Sciences, İstanbul, Turkey.

Houssem Boulebd (H)

Department of Chemistry, Faculty of Exact Sciences, University of Constantine 1, Constantine, Algeria.

Talia Serseg (T)

Laboratory of Fundamental Sciences, Faculty of Sciences, University of Amar Telidji, Laghouat, Algeria.
Laboratoire des Sciences Appliquées et Didactiques, Ecole Normale Supérieure de Laghouat, Algeria.

Abderahmane Linani (A)

Laboratory of Fundamental Sciences, Faculty of Sciences, University of Amar Telidji, Laghouat, Algeria.

Alaeddine Kaouka (A)

Laboratoire des Sciences Appliquées et Didactiques, Ecole Normale Supérieure de Laghouat, Algeria.

Mohamed Yousfi (M)

Laboratory of Fundamental Sciences, Faculty of Sciences, University of Amar Telidji, Laghouat, Algeria.

Asad Syed (A)

Department of Botany and Microbiology, College of Science, King Saud University, P.O. 2455, Riyadh 11451, Saudi Arabia.

Abdallah M Elgorban (AM)

Department of Botany and Microbiology, College of Science, King Saud University, P.O. 2455, Riyadh 11451, Saudi Arabia.

Yasuhiro Ozeki (Y)

Graduate School of NanoBio Sciences, Yokohama City University, 22-2 Seto, Kanazawa-ku, Yokohama 236-0027, Japan.

Sarkar M A Kawsar (SMA)

Laboratory of Carbohydrate and Nucleoside Chemistry, Department of Chemistry, Faculty of Science, University of Chittagong, Chittagong 4331, Bangladesh.

Classifications MeSH