Acute adverse events of ultra-hypofractionated whole-breast irradiation after breast-conserving surgery for early breast cancer in Japan: an interim analysis of the multi-institutional phase II UPBEAT study.

Breast cancer Interim analysis Phase II study Ultra-hypofractionated radiation therapy Whole-breast irradiation

Journal

Breast cancer (Tokyo, Japan)
ISSN: 1880-4233
Titre abrégé: Breast Cancer
Pays: Japan
ID NLM: 100888201

Informations de publication

Date de publication:
12 Apr 2024
Historique:
received: 18 01 2024
accepted: 24 03 2024
medline: 12 4 2024
pubmed: 12 4 2024
entrez: 12 4 2024
Statut: aheadofprint

Résumé

The applicability of ultra-hypofractionated (ultra-HF) whole-breast irradiation (WBI) remains unknown in Japanese women. This study aimed to evaluate the safety and efficacy of this approach among Japanese women and report the results of an interim analysis performed to assess acute adverse events (AEs) and determine whether it was safe to continue this study. We enrolled Japanese women with invasive breast cancer or ductal carcinoma in situ who had undergone breast-conserving surgery, were aged ≥ 40 years, had pathological stages of Tis-T3 N0-N1, and had negative surgical margins. Ultra-HF-WBI was delivered at 26 Gy in five fractions over one week. When the number of enrolled patients reached 28, patient registration was paused for three months. The endpoint of the interim analysis was the proportion of acute AEs of grade ≥ 2 (Common Terminology Criteria for Adverse Events v5.0) within three months. Of the 28 patients enrolled from seven institutes, 26 received ultra-HF-WBI, and 2 were excluded due to postoperative infections. No AEs of grade ≥ 3 occurred. One patient (4%) experienced grade 2 radiation dermatitis, and 18 (69%) had grade 1 radiation dermatitis. The other acute grade 1 AEs experienced were skin hyperpigmentation (n = 10, 38%); breast pain (n = 4, 15%); superficial soft tissue fibrosis (n = 3, 12%); and fatigue (n = 1, 4%). No other acute AEs of grade ≥ 2 were detected. Acute AEs following ultra-HF-WBI were within acceptable limits among Japanese women, indicating that the continuation of the study was appropriate.

Sections du résumé

BACKGROUND BACKGROUND
The applicability of ultra-hypofractionated (ultra-HF) whole-breast irradiation (WBI) remains unknown in Japanese women. This study aimed to evaluate the safety and efficacy of this approach among Japanese women and report the results of an interim analysis performed to assess acute adverse events (AEs) and determine whether it was safe to continue this study.
METHODS METHODS
We enrolled Japanese women with invasive breast cancer or ductal carcinoma in situ who had undergone breast-conserving surgery, were aged ≥ 40 years, had pathological stages of Tis-T3 N0-N1, and had negative surgical margins. Ultra-HF-WBI was delivered at 26 Gy in five fractions over one week. When the number of enrolled patients reached 28, patient registration was paused for three months. The endpoint of the interim analysis was the proportion of acute AEs of grade ≥ 2 (Common Terminology Criteria for Adverse Events v5.0) within three months.
RESULTS RESULTS
Of the 28 patients enrolled from seven institutes, 26 received ultra-HF-WBI, and 2 were excluded due to postoperative infections. No AEs of grade ≥ 3 occurred. One patient (4%) experienced grade 2 radiation dermatitis, and 18 (69%) had grade 1 radiation dermatitis. The other acute grade 1 AEs experienced were skin hyperpigmentation (n = 10, 38%); breast pain (n = 4, 15%); superficial soft tissue fibrosis (n = 3, 12%); and fatigue (n = 1, 4%). No other acute AEs of grade ≥ 2 were detected.
CONCLUSIONS CONCLUSIONS
Acute AEs following ultra-HF-WBI were within acceptable limits among Japanese women, indicating that the continuation of the study was appropriate.

Identifiants

pubmed: 38607499
doi: 10.1007/s12282-024-01577-3
pii: 10.1007/s12282-024-01577-3
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

© 2024. The Author(s).

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Auteurs

Peter J K Tokuda (PJK)

Department of Radiation Oncology, Kobe City Medical Center General Hospital, 2-1-1, Minatojima Minamimachi, Chuo-ku, Kobe, Hyogo, 650-0047, Japan.

Takamasa Mitsuyoshi (T)

Department of Radiation Oncology, Kobe City Medical Center General Hospital, 2-1-1, Minatojima Minamimachi, Chuo-ku, Kobe, Hyogo, 650-0047, Japan. mitsu.t@kuhp.kyoto-u.ac.jp.

Yuka Ono (Y)

Department of Radiation Oncology and Image-Applied Therapy, Graduate School of Medicine, Kyoto University, Kyoto, Kyoto, Japan.

Takahiro Kishi (T)

Department of Radiation Therapy, Osaka Red Cross Hospital, Osaka, Osaka, Japan.

Yoshiharu Negoro (Y)

Department of Radiation Oncology, Japanese Red Cross Wakayama Medical Center, Wakayama, Wakayama, Japan.

Setsuko Okumura (S)

Department of Radiation Oncology, Hyogo Prefectural Amagasaki General Medical Center, Amagasaki, Hyogo, Japan.

Itaru Ikeda (I)

Department of Radiation Oncology, Shiga General Hospital, Moriyama, Shiga, Japan.

Takashi Sakamoto (T)

Department of Radiation Oncology, Kyoto-Katsura Hospital, Kyoto, Kyoto, Japan.

Yumi Kokubo (Y)

Department of Radiation Oncology, Kobe City Medical Center General Hospital, 2-1-1, Minatojima Minamimachi, Chuo-ku, Kobe, Hyogo, 650-0047, Japan.

Ryo Ashida (R)

Department of Radiation Oncology, Kobe City Medical Center General Hospital, 2-1-1, Minatojima Minamimachi, Chuo-ku, Kobe, Hyogo, 650-0047, Japan.

Toshiyuki Imagumbai (T)

Department of Radiation Oncology, Kobe City Medical Center General Hospital, 2-1-1, Minatojima Minamimachi, Chuo-ku, Kobe, Hyogo, 650-0047, Japan.

Mikiko Yamashita (M)

Department of Radiological Technology, Kobe City Medical Center General Hospital, Kobe, Hyogo, Japan.

Hiroaki Tanabe (H)

Department of Radiological Technology, Kobe City Medical Center General Hospital, Kobe, Hyogo, Japan.

Sayaka Takebe (S)

Department of Breast Surgery, Kobe City Medical Center General Hospital, Kobe, Hyogo, Japan.

Mariko Tokiwa (M)

Department of Breast Surgery, Kobe City Medical Center General Hospital, Kobe, Hyogo, Japan.

Eiji Suzuki (E)

Department of Breast Surgery, Kobe City Medical Center General Hospital, Kobe, Hyogo, Japan.

Chikako Yamauchi (C)

Department of Radiation Oncology, Shiga General Hospital, Moriyama, Shiga, Japan.

Michio Yoshimura (M)

Department of Radiation Oncology and Image-Applied Therapy, Graduate School of Medicine, Kyoto University, Kyoto, Kyoto, Japan.

Takashi Mizowaki (T)

Department of Radiation Oncology and Image-Applied Therapy, Graduate School of Medicine, Kyoto University, Kyoto, Kyoto, Japan.

Masaki Kokubo (M)

Department of Radiation Oncology, Kobe City Medical Center General Hospital, 2-1-1, Minatojima Minamimachi, Chuo-ku, Kobe, Hyogo, 650-0047, Japan.

Classifications MeSH